ID   ZUPT_NEIMB              Reviewed;         269 AA.
AC   Q9K1H6;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Zinc transporter ZupT;
GN   Name=zupT; OrderedLocusNames=NMB0175;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
CC   -!- FUNCTION: Mediates zinc uptake. May also transport other divalent
CC       cations (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE002098; AAF40632.1; -; Genomic_DNA.
DR   PIR; G81230; G81230.
DR   RefSeq; NP_273233.1; NC_003112.2.
DR   RefSeq; WP_002224778.1; NC_003112.2.
DR   AlphaFoldDB; Q9K1H6; -.
DR   SMR; Q9K1H6; -.
DR   STRING; 122586.NMB0175; -.
DR   PaxDb; Q9K1H6; -.
DR   EnsemblBacteria; AAF40632; AAF40632; NMB0175.
DR   GeneID; 61282235; -.
DR   KEGG; nme:NMB0175; -.
DR   PATRIC; fig|122586.8.peg.217; -.
DR   HOGENOM; CLU_015114_1_3_4; -.
DR   OMA; MIFVVIE; -.
DR   PRO; PR:Q9K1H6; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR   HAMAP; MF_00548; ZupT; 1.
DR   InterPro; IPR003689; ZIP.
DR   InterPro; IPR023498; Zn_transptr_ZupT.
DR   Pfam; PF02535; Zip; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..269
FT                   /note="Zinc transporter ZupT"
FT                   /id="PRO_0000207275"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   269 AA;  28425 MW;  C301DBD7E1923FF9 CRC64;
     MPDFSMSNLA VAFSITLAAG LFTVLGSGLV MFSKTPNPRV LSFGLAFAGG AMVYVSLTEI
     FSKSSEAFAE IYDKDHAFAA ATMAFLAGMG GIALIDRLVP NPHETLDAQD PSFQESKRRH
     IARVGMMAAF AITAHNFPEG LATFFATLEN PAVGMPLALA IAIHNIPEGI SIAAPVYFAT
     RSRKKTVWAC LLSGLAEPLG AALGYLVLQP FLSPAVFGSV FGVIAGVMVF LALDELLPAA
     KRYSDGHETV YGLTTGMAVI AVSLVLFHF