ID   ZUPT_SHIFL              Reviewed;         257 AA.
AC   Q7UBJ3; Q83JK5;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Zinc transporter ZupT {ECO:0000255|HAMAP-Rule:MF_00548};
GN   Name=zupT {ECO:0000255|HAMAP-Rule:MF_00548};
GN   OrderedLocusNames=SF3080, S3285;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Mediates zinc uptake. May also transport other divalent
CC       cations. {ECO:0000255|HAMAP-Rule:MF_00548}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00548};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00548}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00548}.
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DR   EMBL; AE005674; AAN44558.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18371.1; -; Genomic_DNA.
DR   RefSeq; NP_708851.2; NC_004337.2.
DR   RefSeq; WP_005051906.1; NZ_WPGW01000100.1.
DR   AlphaFoldDB; Q7UBJ3; -.
DR   SMR; Q7UBJ3; -.
DR   STRING; 198214.SF3080; -.
DR   EnsemblBacteria; AAN44558; AAN44558; SF3080.
DR   EnsemblBacteria; AAP18371; AAP18371; S3285.
DR   GeneID; 1026695; -.
DR   GeneID; 58388993; -.
DR   KEGG; sfl:SF3080; -.
DR   KEGG; sfx:S3285; -.
DR   PATRIC; fig|198214.7.peg.3655; -.
DR   HOGENOM; CLU_015114_1_3_6; -.
DR   OMA; MIFVVIE; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00548; ZupT; 1.
DR   InterPro; IPR003689; ZIP.
DR   InterPro; IPR023498; Zn_transptr_ZupT.
DR   Pfam; PF02535; Zip; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..257
FT                   /note="Zinc transporter ZupT"
FT                   /id="PRO_0000207279"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        32..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        64..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        108..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        140..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        169..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        195..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        234..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
SQ   SEQUENCE   257 AA;  26501 MW;  C74A1B113A7A3E7C CRC64;
     MSVPLILTIL AGAATFIGAF LGVLGQKPSN RLLAFSLGFA AGIMLLISLM EMLPAALAAE
     GMSPVLGYGM FIFGLLGYFG LDRMLPHAHP QDLMQKSVQL LPKSIKRTAI LLTLGISLHN
     FPEGIATFVT ASSNLELGFG IALAVALHNI PEGLAVAGPV YAATGSKRTA ILWAGISGLA
     EILGGVLAWL ILGSMISPVV MAAIMAAVAG IMVALSVDEL MPLAKEIDPN NNPSYGVLCG
     MSVMGFSLVL LQTAGIG