ID   ZUPT_STRMU              Reviewed;         264 AA.
AC   Q8DRY7;
DT   03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Zinc transporter ZupT {ECO:0000255|HAMAP-Rule:MF_00548};
GN   Name=zupT {ECO:0000255|HAMAP-Rule:MF_00548}; OrderedLocusNames=SMU_2069;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: Mediates zinc uptake. May also transport other divalent
CC       cations. {ECO:0000255|HAMAP-Rule:MF_00548}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00548};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00548}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00548}.
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DR   EMBL; AE014133; AAN59665.1; -; Genomic_DNA.
DR   RefSeq; NP_722359.1; NC_004350.2.
DR   RefSeq; WP_002262376.1; NC_004350.2.
DR   AlphaFoldDB; Q8DRY7; -.
DR   SMR; Q8DRY7; -.
DR   STRING; 210007.SMU_2069; -.
DR   EnsemblBacteria; AAN59665; AAN59665; SMU_2069.
DR   KEGG; smu:SMU_2069; -.
DR   PATRIC; fig|210007.7.peg.1841; -.
DR   eggNOG; COG0428; Bacteria.
DR   HOGENOM; CLU_015114_1_3_9; -.
DR   OMA; REYGEHH; -.
DR   PhylomeDB; Q8DRY7; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00548; ZupT; 1.
DR   InterPro; IPR003689; ZIP.
DR   InterPro; IPR023498; Zn_transptr_ZupT.
DR   Pfam; PF02535; Zip; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..264
FT                   /note="Zinc transporter ZupT"
FT                   /id="PRO_0000207280"
FT   TRANSMEM        5..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        37..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        72..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        122..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        151..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        183..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        210..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
FT   TRANSMEM        244..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00548"
SQ   SEQUENCE   264 AA;  28317 MW;  BB8F2FC67F6B8ABC CRC64;
     MSQHLFTAFI LTALAGLSTG IGSLIAFVTK HTNKTFLSVS LGFSAGVMIY VSMIEIFPTA
     QTILTKAMDK KSGSWLTVLA FFGGILLIAI IDKLIPSEEN PHEIKTIEEE DQKPTKLMRM
     GLMTAIAIGI HNFPEGLATF ISGLQDASIA IPIVIAIAIH NIPEGIAVSV PIYQATGSKK
     KAFTYSFLSG LAEPLGAIIG WFLLMPIMNN IVYGAIFSAV AGIMVFISLD ELLPAAEEYG
     KHHLAIYGVI SGMLIMAVSL LLFI