ID   ZUR_SHIFL               Reviewed;         171 AA.
AC   P0AC52; P32692; P76784;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Zinc uptake regulation protein;
DE            Short=Zinc uptake regulator;
GN   Name=zur; OrderedLocusNames=SF4159, S3572;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Acts as a negative controlling element, employing Zn(2+) as a
CC       cofactor to bind the operator of the repressed genes (znuACB).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Fur family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN45581.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAP18618.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005674; AAN45581.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014073; AAP18618.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_709874.3; NC_004337.2.
DR   RefSeq; WP_001295691.1; NZ_WPGW01000150.1.
DR   AlphaFoldDB; P0AC52; -.
DR   SMR; P0AC52; -.
DR   STRING; 198214.SF4159; -.
DR   EnsemblBacteria; AAN45581; AAN45581; SF4159.
DR   EnsemblBacteria; AAP18618; AAP18618; S3572.
DR   GeneID; 1026802; -.
DR   GeneID; 66672039; -.
DR   KEGG; sfl:SF4159; -.
DR   KEGG; sfx:S3572; -.
DR   PATRIC; fig|198214.7.peg.4907; -.
DR   HOGENOM; CLU_096072_2_1_6; -.
DR   OrthoDB; 1944289at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07153; Fur_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.1490.190; -; 1.
DR   InterPro; IPR002481; FUR.
DR   InterPro; IPR043135; Fur_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33202; PTHR33202; 1.
DR   Pfam; PF01475; FUR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..171
FT                   /note="Zinc uptake regulation protein"
FT                   /id="PRO_0000095593"
SQ   SEQUENCE   171 AA;  19254 MW;  84B712B1BBF00D41 CRC64;
     MEKTTTQELL AQAEKICAQR NVRLTPQRLE VLRLMSLQDG AISAYDLLDL LREAEPQAKP
     PTVYRALDFL LEQGFVHKVE STNSYVLCHL FDQPTHTSAM FICDRCGAVK EECAEGVEDI
     MHTLAAKMGF ALRHNVIEAH GLCAACVEVE ACRHPEQCQH DHSVQVKKKP R