ID   ZW10_DROGR              Reviewed;         714 AA.
AC   O44219;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Centromere/kinetochore protein zw10;
DE   AltName: Full=Mitotic 15 protein;
GN   Name=mit(1)15; Synonyms=ZW10;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9298984; DOI=10.1083/jcb.138.6.1289;
RA   Starr D.A., Williams B.C., Li Z., Etemad-Moghadam B., Dawe R.K.,
RA   Goldberg M.L.;
RT   "Conservation of the centromere/kinetochore protein ZW10.";
RL   J. Cell Biol. 138:1289-1301(1997).
CC   -!- FUNCTION: Required for accurate chromosome segregation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Chromosome, centromere, kinetochore {ECO:0000250}. Note=Excluded from
CC       the nucleus during interphase but migrates into the nuclear zone during
CC       prometaphase. At metaphase, found in a filamentous structure that may
CC       be specifically associated with kinetochore microtubules. At anaphase,
CC       found at or near kinetochores of separating chromosomes. At the
CC       beginning of telophase, becomes excluded again from the nucleus and is
CC       dispersed in the cytoplasm (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZW10 family. {ECO:0000305}.
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DR   EMBL; U54998; AAB88238.1; -; Genomic_DNA.
DR   AlphaFoldDB; O44219; -.
DR   STRING; 7222.FBpp0151795; -.
DR   eggNOG; KOG2163; Eukaryota.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:InterPro.
DR   Gene3D; 1.10.357.150; -; 1.
DR   InterPro; IPR009361; RZZ-complex_Zw10.
DR   InterPro; IPR046362; Zw10/DSL1_C_sf.
DR   Pfam; PF06248; Zw10; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Kinetochore;
KW   Meiosis; Mitosis; Nucleus.
FT   CHAIN           1..714
FT                   /note="Centromere/kinetochore protein zw10"
FT                   /id="PRO_0000184961"
SQ   SEQUENCE   714 AA;  81262 MW;  62E14636E9D5B12D CRC64;
     MAETQVLLET YQGQGNNNAT NIEATKAAIK KMLVRIERFQ TRVRKHIDEN YVDFMPNHTS
     PDIFLEKSSA LGDEISDLLA TVGNEGLSVL SDASVELAAL SRDLREKLFG LRVSEHILKL
     DDLFQCVEEA KSTKDCLVVL DLMGRLRSLI YGEGTSDDIS PDVERIFQSL ECYESIKVKY
     HVQAHLLQQN LQERFDRLVQ LSCKSFPTSK CVTLLISKDE ALLQDIVIAL FQESYNPTKL
     CAFLLENCIE PLIQKPVSVE YNVNAKDGTH IQLTLSYSIK EPDTSSLLRP NYKDVFEHFR
     LLLKTLCGIN SSLNGTQHVF TVIGDHVKER MLQLLLDECL IRVPETMDEY NSSTLCEDVA
     EFEHQLVDTF LINPELDTTL TEFTKQFDTY YRNRLSERVL ATAREIIQRD LQDMTLVAPS
     NLSANVASDP LLFPRCMVSK SAQVDFVKLM ERVVRQPDKA AEGTPDPLGG VIGLLLDAYI
     NEVPKVHKKL LKSIPQQSAL FYNNCMYLTH WVAQHTKDNI DGFPSLVKIL QSTGNKHLRV
     QVSYQESILM DIMSSFEFEN PHTLGTAPLR LVRQCLRQLE LLKNVWQQVP AENVYNNSFC
     ELLQAFINEL VQRVFSLRDI SATMASELSD LIDVVLEKAS ILFHDKNDVV HVRSWLKLQQ
     LKIMMNASLK EFSELWCDGV GPLTANYHAD EIKHLIRALF QDTDRRAKAI TQIV