ID   ZW10_DROPS              Reviewed;         718 AA.
AC   O44218; Q29GT8;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Centromere/kinetochore protein zw10;
DE   AltName: Full=Mitotic 15 protein;
GN   Name=mit(1)15; Synonyms=ZW10; ORFNames=GA22111;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 240-718.
RX   PubMed=9298984; DOI=10.1083/jcb.138.6.1289;
RA   Starr D.A., Williams B.C., Li Z., Etemad-Moghadam B., Dawe R.K.,
RA   Goldberg M.L.;
RT   "Conservation of the centromere/kinetochore protein ZW10.";
RL   J. Cell Biol. 138:1289-1301(1997).
CC   -!- FUNCTION: Required for accurate chromosome segregation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Chromosome, centromere, kinetochore {ECO:0000250}. Note=Excluded from
CC       the nucleus during interphase but migrates into the nuclear zone during
CC       prometaphase. At metaphase, found in a filamentous structure that may
CC       be specifically associated with kinetochore microtubules. At anaphase,
CC       found at or near kinetochores of separating chromosomes. At the
CC       beginning of telophase, becomes excluded again from the nucleus and is
CC       dispersed in the cytoplasm (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZW10 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL32021.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH379064; EAL32021.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; U54997; AAB88239.1; -; Genomic_DNA.
DR   RefSeq; XP_001354965.1; XM_001354929.2.
DR   AlphaFoldDB; O44218; -.
DR   SMR; O44218; -.
DR   STRING; 7237.FBpp0280645; -.
DR   EnsemblMetazoa; FBtr0282207; FBpp0280645; FBgn0022854.
DR   GeneID; 4815208; -.
DR   KEGG; dpo:Dpse_GA22111; -.
DR   eggNOG; KOG2163; Eukaryota.
DR   HOGENOM; CLU_012948_0_0_1; -.
DR   InParanoid; O44218; -.
DR   OMA; MMNASLK; -.
DR   PhylomeDB; O44218; -.
DR   Proteomes; UP000001819; Chromosome X.
DR   Bgee; FBgn0022854; Expressed in female reproductive system and 3 other tissues.
DR   GO; GO:0036063; C:acroblast; IEA:EnsemblMetazoa.
DR   GO; GO:0005795; C:Golgi stack; IEA:EnsemblMetazoa.
DR   GO; GO:0005828; C:kinetochore microtubule; IEA:EnsemblMetazoa.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990423; C:RZZ complex; IEA:EnsemblMetazoa.
DR   GO; GO:0051233; C:spindle midzone; IEA:EnsemblMetazoa.
DR   GO; GO:0031267; F:small GTPase binding; IEA:EnsemblMetazoa.
DR   GO; GO:0036090; P:cleavage furrow ingression; IEA:EnsemblMetazoa.
DR   GO; GO:0007030; P:Golgi organization; IEA:EnsemblMetazoa.
DR   GO; GO:0007060; P:male meiosis chromosome segregation; IEA:EnsemblMetazoa.
DR   GO; GO:0007112; P:male meiosis cytokinesis; IEA:EnsemblMetazoa.
DR   GO; GO:0007107; P:membrane addition at site of cytokinesis; IEA:EnsemblMetazoa.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IEA:EnsemblMetazoa.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:EnsemblMetazoa.
DR   Gene3D; 1.10.357.150; -; 1.
DR   InterPro; IPR009361; RZZ-complex_Zw10.
DR   InterPro; IPR046362; Zw10/DSL1_C_sf.
DR   Pfam; PF06248; Zw10; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Kinetochore;
KW   Meiosis; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..718
FT                   /note="Centromere/kinetochore protein zw10"
FT                   /id="PRO_0000184962"
FT   CONFLICT        283..285
FT                   /note="ASG -> PSS (in Ref. 2; AAB88239)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        448
FT                   /note="D -> V (in Ref. 2; AAB88239)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        458
FT                   /note="R -> A (in Ref. 2; AAB88239)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        565
FT                   /note="P -> T (in Ref. 2; AAB88239)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        581
FT                   /note="R -> V (in Ref. 2; AAB88239)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        700
FT                   /note="I -> D (in Ref. 2; AAB88239)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   718 AA;  82076 MW;  858CAB290F4DACEE CRC64;
     MAARAQIKLL PEMFQSNGCA SLEDTKSTVS KVQTRTERFQ ERVRKHIDEN YSEFMTNHTS
     PDIFLEESSS LGREINDLLE TVGTEGLAAL NGSSTQLADH SRELRELMLG LQVSEHILKI
     DELFQCVEEA KGTKDYLVVL DLVGRLRSLI YGEGEAATQD VVRIFQALEC YETIKVKYHV
     QAHLLQQNMQ ERFDRLVQLN CKSFPNSKCV TLLVSKEEGQ LHDIVIALFQ ERYNPVRLCE
     FLLENCIEPL ILKPVGVECN ENAEAGTYVQ LSLSYSTKES GTASGTSTQL RPNYKQVLEH
     FRLLLQTLSG INHSLSSSQH VFSIIGDHVK DRMMHLLVND CLIPAVPETM EEYQASTLCE
     DVAHFEQYLA DSFLINPEVD RGLSQFIEQY GTYYRNRLCS RVLESTREII QRDLQDMVLV
     APNNQAMDVT GCDPFLFPRC MVSRSAQDFM KLMERILRQP TEKPGEDEAD PLAGVIGMML
     QTYIDEVPKV HKKLLESIPQ QSVLFHNNCM YFTHWVAQNA NKGIESFPAL VKTLQATGTM
     HFRVQVTYQT SILMDIMESF EFESPHTLGT GPLKLVRQCL RQLELLKNVW QNVLPDNVYN
     STFVELLHAF INELVRHIFT QRDISATMAS DLSDLIDVVL EKAPKLFRDP HEVHQVRSWM
     KLQQLKTMMN ASLKEITELW CKGAGPLTAN YKADEIRYLI RALFQDTDRR AKAITQIM