ID   ZWILC_BOVIN             Reviewed;         589 AA.
AC   A6QM04;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Protein zwilch homolog;
GN   Name=ZWILCH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the mitotic checkpoint, which prevents
CC       cells from prematurely exiting mitosis. Required for the assembly of
CC       the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its
CC       function related to the spindle assembly machinery is proposed to
CC       depend on its association in the mitotic RZZ complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q9H900}.
CC   -!- SUBUNIT: Component of the RZZ complex composed of KNTC1/ROD, ZW10 and
CC       ZWILCH; in the complex interacts directly with KNTC1/ROD (By
CC       similarity). {ECO:0000250|UniProtKB:Q9H900}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q9H900}.
CC   -!- SIMILARITY: Belongs to the ZWILCH family. {ECO:0000305}.
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DR   EMBL; BC148150; AAI48151.1; -; mRNA.
DR   RefSeq; NP_001095649.1; NM_001102179.1.
DR   AlphaFoldDB; A6QM04; -.
DR   SMR; A6QM04; -.
DR   STRING; 9913.ENSBTAP00000006867; -.
DR   PaxDb; A6QM04; -.
DR   PRIDE; A6QM04; -.
DR   Ensembl; ENSBTAT00000006867; ENSBTAP00000006867; ENSBTAG00000005213.
DR   GeneID; 534811; -.
DR   KEGG; bta:534811; -.
DR   CTD; 55055; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005213; -.
DR   VGNC; VGNC:37391; ZWILCH.
DR   eggNOG; KOG4803; Eukaryota.
DR   GeneTree; ENSGT00390000013696; -.
DR   HOGENOM; CLU_466141_0_0_1; -.
DR   InParanoid; A6QM04; -.
DR   OMA; CAAEEFY; -.
DR   OrthoDB; 1451737at2759; -.
DR   TreeFam; TF324453; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000005213; Expressed in oocyte and 110 other tissues.
DR   ExpressionAtlas; A6QM04; baseline and differential.
DR   GO; GO:1990423; C:RZZ complex; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0034501; P:protein localization to kinetochore; IBA:GO_Central.
DR   InterPro; IPR018630; Zwilch.
DR   PANTHER; PTHR15995; PTHR15995; 1.
DR   Pfam; PF09817; Zwilch; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Kinetochore; Mitosis;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..589
FT                   /note="Protein zwilch homolog"
FT                   /id="PRO_0000314799"
FT   MOD_RES         88
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H900"
SQ   SEQUENCE   589 AA;  66385 MW;  E12E51A28817F609 CRC64;
     MWSGANRAAE EFYAGLLQEF DENKKGIRKD PFIYEADIQV QLISKGQPNP LKNILHENET
     IFIVEKVPLE KEEPSPIEEL QSEDTAISDL STGENVGLLA LPIGRARQLI GFYTMAHNPN
     MTHLKINRPV TALPPLWVRC DGSDPEGISW LGAELISTSS NITGIVLYMV TCKVDKNYSV
     NLEDLKKSHK KRHHLSTLTA SGFARYELFK STALDDTVAA SQTTITLDIS WSPVDEILQT
     PPLSSTATLN IKVESGEPRG PLSQLHRELK FLLVLADGLR TGVTEWPEPL EAKSAVELVQ
     EFLNELSKLN EFGDSTKKDT EIVKHDAAAV DGSIECLLTV RGDLDFAEQL WCKMSSSVIS
     YQDLVKCFSL VIQSLQRGAI QPWLHSGSNS LLSKLIHQSY YGTMDTVSLS GTVPVQMLLE
     IGLDKLKKDY ICFFIGQELA SLNHLEYFIS PSVDTQEQVH RVQKLHHILE IVVSCMLFIK
     PQHELLFSLT QSCIKYYEQN PLDEQHIFQL PVRPTAVKDL YQNEKPQKWR VEINSGQKKV
     KTVWQLSDSP PIDHLNFHRP DFSELTLSGS LEERISFTNM VTCSQVHFK