ID   ZWILC_PONAB             Reviewed;         591 AA.
AC   Q5RA78;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Protein zwilch homolog;
GN   Name=ZWILCH;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the mitotic checkpoint, which prevents
CC       cells from prematurely exiting mitosis. Required for the assembly of
CC       the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its
CC       function related to the spindle assembly machinery is proposed to
CC       depend on its association in the mitotic RZZ complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q9H900}.
CC   -!- SUBUNIT: Component of the RZZ complex composed of KNTC1/ROD, ZW10 and
CC       ZWILCH; in the complex interacts directly with KNTC1/ROD (By
CC       similarity). {ECO:0000250|UniProtKB:Q9H900}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q9H900}.
CC   -!- SIMILARITY: Belongs to the ZWILCH family. {ECO:0000305}.
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DR   EMBL; CR859141; CAH91332.1; -; mRNA.
DR   RefSeq; NP_001125787.1; NM_001132315.2.
DR   AlphaFoldDB; Q5RA78; -.
DR   SMR; Q5RA78; -.
DR   STRING; 9601.ENSPPYP00000007461; -.
DR   GeneID; 100172715; -.
DR   KEGG; pon:100172715; -.
DR   CTD; 55055; -.
DR   eggNOG; KOG4803; Eukaryota.
DR   InParanoid; Q5RA78; -.
DR   OrthoDB; 1451737at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:1990423; C:RZZ complex; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; ISS:UniProtKB.
DR   InterPro; IPR018630; Zwilch.
DR   PANTHER; PTHR15995; PTHR15995; 1.
DR   Pfam; PF09817; Zwilch; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Kinetochore; Mitosis;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..591
FT                   /note="Protein zwilch homolog"
FT                   /id="PRO_0000314802"
FT   MOD_RES         88
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H900"
SQ   SEQUENCE   591 AA;  67186 MW;  62E97727690023A9 CRC64;
     MWERLNCAAE DFYSRLLQKF NEEKKGIRKD PFLYEADVQV QLISKGQPNP LKNILNENDI
     VFIVEKVPLE KEETSHIEEL QSEETAISDF STGENVGPLA LPVGKARQLI GLYTMAHNPN
     MTHLKINLPV TALPPLWVRC DSSDPEGTCW LGAELITTNN SITGIVLYVV SCKADKNYSV
     NLENLKNLHK KRHHLSTVTS KGFAQYELFK SSALDDTITA SQTAIALDIS WSPADEILQI
     PPLSSTATLN IKVESGEPRG PLNHLYRELK FLLVLADGLR TGVTEWLEPL EAKSAVELVQ
     EFLNDLNKLD GFGDSTKKDT EVETLKHDTA AVDRSVKRLF KVRSDLDFAE QLWCKMSSSV
     ISYQDLVKCF TLIIQSLQRG DIQPWLHSGS NSLLSKLIHQ SYHGTMDTVS LSGTIPVQML
     LEIGLDKLKK DYISFFIGQE LASLNHLEYF IAPSVDIQEQ VYRVQKLHHI LEILVSCMPF
     IKSQHELLFS LTQICIKYYK QNPLDEQHIF QLPVRPTAVK NLYQSEKPQK WRVEIYSGQK
     KIKTVWQLSD SSPIDHLNFH KPDFSELTLN GSLEERIFFT NMVTCSQVHF K