ID   ZWILC_XENLA             Reviewed;         597 AA.
AC   Q6IRM9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Protein zwilch homolog;
GN   Name=zwilch;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the mitotic checkpoint, which prevents
CC       cells from prematurely exiting mitosis. Required for the assembly of
CC       the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RZZ complex composed of kntc1/rod, zw10 and
CC       zwilch. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZWILCH family. {ECO:0000305}.
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DR   EMBL; BC070818; AAH70818.1; -; mRNA.
DR   RefSeq; NP_001084959.1; NM_001091490.1.
DR   AlphaFoldDB; Q6IRM9; -.
DR   SMR; Q6IRM9; -.
DR   MaxQB; Q6IRM9; -.
DR   DNASU; 432018; -.
DR   GeneID; 432018; -.
DR   KEGG; xla:432018; -.
DR   CTD; 432018; -.
DR   Xenbase; XB-GENE-5861117; zwilch.S.
DR   OMA; CAAEEFY; -.
DR   OrthoDB; 1451737at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 432018; Expressed in oocyte and 19 other tissues.
DR   GO; GO:1990423; C:RZZ complex; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; ISS:UniProtKB.
DR   InterPro; IPR018630; Zwilch.
DR   PANTHER; PTHR15995; PTHR15995; 1.
DR   Pfam; PF09817; Zwilch; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Kinetochore; Mitosis;
KW   Reference proteome.
FT   CHAIN           1..597
FT                   /note="Protein zwilch homolog"
FT                   /id="PRO_0000314804"
SQ   SEQUENCE   597 AA;  67380 MW;  52D3774423F0DBCE CRC64;
     MWAERHRAAV ELQQFLSSVY EQVKKEESLG PFQFKDDIQV HVVCDGHCKP LESFCSGSEV
     LYILEKKPLT LEDNVLDETE NNEGISFYTS LQEIPQPQAI PTMRARQFLT SYTLTHNPNM
     VQLNSGAPVK VLPPLWVRCD CSDAEGTCWL GAEPIKSSRN EITGMSFRTV TCAGPTADKS
     TFPSLDSLRQ AHKERHYSSV MQTRGFAQYD LFGCNTVENS VIESQSSVTV DFVWNGVERI
     LQLPPLASAA TLNIKVESGD LRSPVYSVYK ELDFLLVLAE GLKTGVTEWP ETGETKSAVD
     LVQLLLNDLK NKVDGLTSSV SKKDNEKIKS DTAAVDCSIQ SFITERGDLD FAEMLWCRMR
     KSVSSYQDVV NCFSLVIQSL KNGEVHPWIH RGSSSALSKL IQQSYHGKMQ SVSLTGLTPM
     RMLLEIGLDK MKKDYISCFI GQDLATFNYL DYFISSSVDI QEQVQRVKKL HHMLEVVVVC
     NAFLSLGHEN LFPLTQSCLK YYKENPWNEQ HVFQLPIRPS VISTFYQNSH PQTWRVEIIS
     GHGQKEVKTT WQLTSRRPVD HVSFAVPDVP IDMTISGENE EIVYYPTQVS CSQVNFC