ID   ZWILC_XENTR             Reviewed;         597 AA.
AC   Q0IJ01;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Protein zwilch homolog;
GN   Name=zwilch;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the mitotic checkpoint, which prevents
CC       cells from prematurely exiting mitosis. Required for the assembly of
CC       the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RZZ complex composed of kntc1/rod, zw10 and
CC       zwilch. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZWILCH family. {ECO:0000305}.
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DR   EMBL; BC121311; AAI21312.1; -; mRNA.
DR   RefSeq; NP_001016216.1; NM_001016216.2.
DR   AlphaFoldDB; Q0IJ01; -.
DR   SMR; Q0IJ01; -.
DR   STRING; 8364.ENSXETP00000034676; -.
DR   PaxDb; Q0IJ01; -.
DR   DNASU; 548970; -.
DR   GeneID; 548970; -.
DR   KEGG; xtr:548970; -.
DR   CTD; 55055; -.
DR   Xenbase; XB-GENE-5861097; zwilch.
DR   eggNOG; KOG4803; Eukaryota.
DR   HOGENOM; CLU_466141_0_0_1; -.
DR   InParanoid; Q0IJ01; -.
DR   OrthoDB; 1451737at2759; -.
DR   PhylomeDB; Q0IJ01; -.
DR   Reactome; R-XTR-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-XTR-2467813; Separation of Sister Chromatids.
DR   Reactome; R-XTR-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-XTR-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-XTR-9648025; EML4 and NUDC in mitotic spindle formation.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:1990423; C:RZZ complex; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0034501; P:protein localization to kinetochore; IBA:GO_Central.
DR   InterPro; IPR018630; Zwilch.
DR   PANTHER; PTHR15995; PTHR15995; 1.
DR   Pfam; PF09817; Zwilch; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Kinetochore; Mitosis;
KW   Reference proteome.
FT   CHAIN           1..597
FT                   /note="Protein zwilch homolog"
FT                   /id="PRO_0000314805"
SQ   SEQUENCE   597 AA;  67494 MW;  5B9862631FBE635B CRC64;
     MWAERHRAAV ELQQFLSSIY EQVKKGESLG PFQYKDDVQV HVVCDGHCKP LENFCSGSEV
     LYIMEKKPLT LEDNALDETE NNEGISFYMS LQESPQPQAI PTMSARQFLT SYTLTHNPNM
     IQLNSGVPVK VLPPLWVRCD SSDAEGTCWL GAEPIKSNRN EITGMSFRTV TCAGPTADKS
     TFPSLDSLRQ AHKERHYSSA MQTRGFAQYD LFGSNTVENS VIESQSSVTV DFVWNGVERI
     LQLPPLTSAA TLNIKVESGD LRSPVYSVYK ELDFLLVLAE GLKTGVTEWP ETSETKSAVD
     LVQHLLNDLK NKVDGLSTSV SKKDNEKIKS DTAAVDCSIQ SFITERGDLD FAEMLWCKMR
     KSVSSYQDVV NCFSLVIQSL KHGEMHPWIH RGSSSTLSKL IQESYHGDMQ SLSLTGLTPM
     RMLLEIGLDK MKKDYINCFI GQDLATFNYL DYFICTSVDL QEQVQRVKKL HHMLEVVVVC
     NAFLSLGHEN LFPLTQSCLK YYKENPWNEQ HVFQLPIRPS VISTFYQNSH PQTWRVEIIS
     GHGQKEVKTT WQLTSRRPVD HVSFAVPDVP IDMTISGDNE ELVYYPTQVS CSQVHFC