ID   ZWINT_BOVIN             Reviewed;         286 AA.
AC   Q2TBH8;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=ZW10 interactor;
DE   AltName: Full=ZW10-interacting protein 1;
DE            Short=Zwint-1;
GN   Name=ZWINT;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the MIS12 complex, which is required for kinetochore
CC       formation and spindle checkpoint activity. Required to target ZW10 to
CC       the kinetochore at prometaphase (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ZW10 and MIS12. Interacts with the NDC80
CC       subunit of the NDC80 complex specifically during mitosis. Also
CC       interacts with KNL1, CETN3, DSN1 and PMF1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Localizes to kinetochores from late
CC       prophase to anaphase. {ECO:0000250}.
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DR   EMBL; BC110184; AAI10185.1; -; mRNA.
DR   RefSeq; NP_001035619.1; NM_001040529.2.
DR   AlphaFoldDB; Q2TBH8; -.
DR   SMR; Q2TBH8; -.
DR   STRING; 9913.ENSBTAP00000003439; -.
DR   PaxDb; Q2TBH8; -.
DR   GeneID; 514564; -.
DR   KEGG; bta:514564; -.
DR   CTD; 11130; -.
DR   eggNOG; ENOG502S6PG; Eukaryota.
DR   InParanoid; Q2TBH8; -.
DR   OrthoDB; 1313012at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR029092; Zwint-1.
DR   PANTHER; PTHR31504; PTHR31504; 1.
DR   Pfam; PF15556; Zwint; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..286
FT                   /note="ZW10 interactor"
FT                   /id="PRO_0000249581"
FT   REGION          80..155
FT                   /note="Interaction with NDC80 and ZW10"
FT                   /evidence="ECO:0000250"
FT   REGION          230..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          85..211
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        241..261
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   286 AA;  32629 MW;  00B08CC83306270F CRC64;
     MGAAESEVET AAREVLAKVA DIQEPVGFQE EAELPAQILA EFVMDSRKKD KLLCSQLQVV
     DFLQNFLVQE GTAQDQNPLA SEDTSRQKAL EAKEQWKELK ATYQEHVEVI TNSLTEALPK
     VEEAQIKQAQ LQEALKQLQA KKQMAMEKLR IAQKQWQLEQ EKHLQNLAEA SSEVRERQTG
     AQQELQRLYQ ELGTLKQQAG QEKDKLQRHQ TFLQLLYTLQ GKQLFNEAEA EIPQELDLPK
     DKLQQVTQPQ EQNTQDTMGR EADNPQPVGD AGLPWLPGRQ QHKEES