ZWIP6_ARATH
ID ZWIP6_ARATH Reviewed; 302 AA.
AC Q9FX68;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Zinc finger protein WIP6;
DE AltName: Full=Protein DEFECTIVELY ORGANIZED TRIBUTARIES 5 {ECO:0000303|PubMed:18643975};
DE AltName: Full=WIP-domain protein 6 {ECO:0000303|PubMed:11782451};
DE Short=AtWIP6 {ECO:0000303|PubMed:11782451};
GN Name=WIP6 {ECO:0000303|PubMed:11782451};
GN Synonyms=DOT5 {ECO:0000303|PubMed:18643975};
GN OrderedLocusNames=At1g13290 {ECO:0000312|Araport:AT1G13290};
GN ORFNames=T6J4.5 {ECO:0000312|EMBL:AAG09553.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11782451; DOI=10.1101/gad.212702;
RA Sagasser M., Lu G.-H., Hahlbrock K., Weisshaar B.;
RT "A. thaliana TRANSPARENT TESTA 1 is involved in seed coat development and
RT defines the WIP subfamily of plant zinc finger proteins.";
RL Genes Dev. 16:138-149(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9666060; DOI=10.1016/s0378-1119(98)00286-8;
RA Terryn N., Gielen J., De Keyser A., Van Den Daele H., Ardiles W., Neyt P.,
RA De Clercq R., Coppieters J., Dehais P., Villarroel R., Rouze P.,
RA van Montagu M.;
RT "Sequence analysis of a 40-kb Arabidopsis thaliana genomic region located
RT at the top of chromosome 1.";
RL Gene 215:11-17(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=18643975; DOI=10.1111/j.1365-313x.2008.03595.x;
RA Petricka J.J., Clay N.K., Nelson T.M.;
RT "Vein patterning screens and the defectively organized tributaries mutants
RT in Arabidopsis thaliana.";
RL Plant J. 56:251-263(2008).
RN [5]
RP SUBCELLULAR LOCATION, AND ZINC-FINGER.
RX PubMed=20541552; DOI=10.1016/j.febslet.2010.06.007;
RA Appelhagen I., Huep G., Lu G.H., Strompen G., Weisshaar B., Sagasser M.;
RT "Weird fingers: functional analysis of WIP domain proteins.";
RL FEBS Lett. 584:3116-3122(2010).
CC -!- FUNCTION: Probable transcriptional regulator (Probable). Involved in
CC leaf vasculature patterning (PubMed:18643975).
CC {ECO:0000269|PubMed:18643975, ECO:0000305|PubMed:20541552}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20541552}.
CC -!- DISRUPTION PHENOTYPE: Defects in venation pattern in leaves and
CC cotyledons, altered phyllotaxy of vegetative leaves, short roots, delay
CC in leaf initiation and reduced apical dominance.
CC {ECO:0000269|PubMed:18643975}.
CC -!- SIMILARITY: Belongs to the WIP C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; AJ311809; CAC86166.1; -; mRNA.
DR EMBL; AC011810; AAG09553.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28995.1; -; Genomic_DNA.
DR PIR; E86267; E86267.
DR RefSeq; NP_172787.1; NM_101200.2.
DR AlphaFoldDB; Q9FX68; -.
DR STRING; 3702.AT1G13290.1; -.
DR PaxDb; Q9FX68; -.
DR PRIDE; Q9FX68; -.
DR EnsemblPlants; AT1G13290.1; AT1G13290.1; AT1G13290.
DR GeneID; 837889; -.
DR Gramene; AT1G13290.1; AT1G13290.1; AT1G13290.
DR KEGG; ath:AT1G13290; -.
DR Araport; AT1G13290; -.
DR TAIR; locus:2205334; AT1G13290.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_052255_1_0_1; -.
DR InParanoid; Q9FX68; -.
DR OMA; IRYDHFR; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9FX68; -.
DR PRO; PR:Q9FX68; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FX68; baseline and differential.
DR Genevisible; Q9FX68; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0010588; P:cotyledon vascular tissue pattern formation; IMP:TAIR.
DR GO; GO:0010305; P:leaf vascular tissue pattern formation; IMP:TAIR.
DR GO; GO:0010087; P:phloem or xylem histogenesis; IMP:TAIR.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR GO; GO:0048364; P:root development; IMP:TAIR.
DR GO; GO:0048367; P:shoot system development; IMP:TAIR.
DR InterPro; IPR043584; WIP1/2/3/4/5/6.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45878; PTHR45878; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..302
FT /note="Zinc finger protein WIP6"
FT /id="PRO_0000431320"
FT ZN_FING 101..123
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 149..181
FT /note="C2H2-type 2; atypical"
FT /evidence="ECO:0000303|PubMed:20541552"
FT ZN_FING 186..209
FT /note="C2H2-type 3; atypical"
FT /evidence="ECO:0000303|PubMed:20541552"
FT ZN_FING 213..238
FT /note="C2H2-type 4; atypical"
FT /evidence="ECO:0000303|PubMed:20541552"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 178..181
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250|UniProtKB:Q8VWG3"
FT MOTIF 222..225
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250|UniProtKB:Q8VWG3"
FT COMPBIAS 22..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..274
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 302 AA; 34347 MW; 6B3EE30C90A9A068 CRC64;
MYNNNQYSFS GDEDSVVLSL GPPGQQYPSH NKPTSTKPSS DHEFNHPLTN PNGVTVALHI
GPPSSDKETL SGGNNQEGLT ARQGQYWIPS LSQILVGPTQ FSCSVCNKTF NRFNNMQMHM
WGHGSQYRKG PESLRGTKSS SSILRLPCYC CAEGCKNNID HPRSKPLKDF RTLQTHYKRK
HGAKPFRCRK KCEKTFAVRG DWRTHEKNCG KLWFCVCGSD FKHKRSLKDH VRAFGDGHAA
HTVSDRVVGI GDADEDDEEE EEEEEDDVEE EDAHEENVRG EKNYGIRYDH FRRYGQISDD
NY
