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ZXDB_HUMAN
ID   ZXDB_HUMAN              Reviewed;         803 AA.
AC   P98169; A8K151; Q9UBB3;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 2.
DT   03-AUG-2022, entry version 170.
DE   RecName: Full=Zinc finger X-linked protein ZXDB;
GN   Name=ZXDB;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 307-709, AND TISSUE SPECIFICITY.
RC   TISSUE=Brain;
RX   PubMed=8268913; DOI=10.1093/hmg/2.10.1611;
RA   Greig G.M., Sharp C.B., Carrel L., Willard H.F.;
RT   "Duplicated zinc finger protein genes on the proximal short arm of the
RT   human X chromosome: isolation, characterization and X-inactivation
RT   studies.";
RL   Hum. Mol. Genet. 2:1611-1618(1993).
CC   -!- FUNCTION: Cooperates with CIITA to promote transcription of MHC class I
CC       and MHC class II genes. {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Interacts with ZXDC and CIITA (By
CC       similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       P98169; P38919: EIF4A3; NbExp=3; IntAct=EBI-17493569, EBI-299104;
CC       P98169; A0A024R8A9: USP20; NbExp=3; IntAct=EBI-17493569, EBI-14096082;
CC       P98169; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-17493569, EBI-10183064;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: May be expressed in brain, heart, kidney, liver,
CC       lung, muscle and placenta. {ECO:0000269|PubMed:8268913}.
CC   -!- SIMILARITY: Belongs to the ZXD family. {ECO:0000305}.
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DR   EMBL; AK289766; BAF82455.1; -; mRNA.
DR   EMBL; AL031115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z99130; CAB16205.1; -; Genomic_DNA.
DR   EMBL; CH471154; EAW93246.1; -; Genomic_DNA.
DR   EMBL; L14788; AAC37522.1; -; mRNA.
DR   CCDS; CCDS35313.1; -.
DR   PIR; I54340; I54340.
DR   RefSeq; NP_009088.1; NM_007157.3.
DR   AlphaFoldDB; P98169; -.
DR   SMR; P98169; -.
DR   BioGRID; 127694; 19.
DR   IntAct; P98169; 3.
DR   STRING; 9606.ENSP00000364023; -.
DR   iPTMnet; P98169; -.
DR   PhosphoSitePlus; P98169; -.
DR   BioMuta; ZXDB; -.
DR   DMDM; 12644370; -.
DR   EPD; P98169; -.
DR   jPOST; P98169; -.
DR   MassIVE; P98169; -.
DR   MaxQB; P98169; -.
DR   PaxDb; P98169; -.
DR   PeptideAtlas; P98169; -.
DR   PRIDE; P98169; -.
DR   ProteomicsDB; 57802; -.
DR   Antibodypedia; 77180; 4 antibodies from 4 providers.
DR   DNASU; 158586; -.
DR   Ensembl; ENST00000374888.3; ENSP00000364023.1; ENSG00000198455.5.
DR   GeneID; 158586; -.
DR   KEGG; hsa:158586; -.
DR   MANE-Select; ENST00000374888.3; ENSP00000364023.1; NM_007157.4; NP_009088.1.
DR   UCSC; uc004dvd.4; human.
DR   CTD; 158586; -.
DR   GeneCards; ZXDB; -.
DR   HGNC; HGNC:13199; ZXDB.
DR   HPA; ENSG00000198455; Low tissue specificity.
DR   MIM; 300236; gene.
DR   neXtProt; NX_P98169; -.
DR   OpenTargets; ENSG00000198455; -.
DR   PharmGKB; PA37764; -.
DR   VEuPathDB; HostDB:ENSG00000198455; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000164739; -.
DR   HOGENOM; CLU_007312_0_0_1; -.
DR   InParanoid; P98169; -.
DR   OMA; KVEWNVH; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; P98169; -.
DR   TreeFam; TF330996; -.
DR   PathwayCommons; P98169; -.
DR   SignaLink; P98169; -.
DR   BioGRID-ORCS; 158586; 11 hits in 668 CRISPR screens.
DR   ChiTaRS; ZXDB; human.
DR   GenomeRNAi; 158586; -.
DR   Pharos; P98169; Tdark.
DR   PRO; PR:P98169; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; P98169; protein.
DR   Bgee; ENSG00000198455; Expressed in germinal epithelium of ovary and 154 other tissues.
DR   Genevisible; P98169; HS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00355; ZnF_C2H2; 10.
DR   SUPFAM; SSF57667; SSF57667; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE   1: Evidence at protein level;
KW   Activator; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..803
FT                   /note="Zinc finger X-linked protein ZXDB"
FT                   /id="PRO_0000047777"
FT   ZN_FING         271..295
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         304..328
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         334..358
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         364..386
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         393..417
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         424..448
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         454..478
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         484..508
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         514..538
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         547..572
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          120..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          271..577
FT                   /note="Required for interaction with ZXDC"
FT                   /evidence="ECO:0000250"
FT   REGION          576..703
FT                   /note="Required for transcriptional activation"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        232..246
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         736
FT                   /note="A -> T (in dbSNP:rs1057338)"
FT                   /id="VAR_033003"
FT   VARIANT         760
FT                   /note="N -> S (in dbSNP:rs1057340)"
FT                   /id="VAR_033004"
FT   VARIANT         764
FT                   /note="D -> N (in dbSNP:rs1057341)"
FT                   /id="VAR_033005"
FT   VARIANT         791
FT                   /note="T -> R (in dbSNP:rs1057343)"
FT                   /id="VAR_033006"
SQ   SEQUENCE   803 AA;  84792 MW;  FD5A6D326FF5A5D4 CRC64;
     MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLLRGP QDGGPGRRRE
     EASTASRGPG PSLLAPRTDQ PSGGGGGGGD DFFLVLLDPV GGDVETAGSG QAAGPVLREE
     AEEGPGLQGG ESGANPAGPT ALGPRCLSAV PTPAPISAPG PAAAFAGTVT IHNQDLLLRF
     ENGVLTLATP PPHAWEPGAA PAQQPGCLIA PQAGFPHAAH PGDCPELPPD LLLAEPAEPA
     PAPAPEEEAE GPAAALGPRG PLGSGPGVVL YLCPEAQCGQ TFAKKHQLKV HLLTHSSSQG
     QRPFKCPLGG CGWTFTTSYK LKRHLQSHDK LRPFGCPAEG CGKSFTTVYN LKAHMKGHEQ
     ENSFKCEVCE ESFPTQAKLS AHQRSHFEPE RPYQCAFSGC KKTFITVSAL FSHNRAHFRE
     QELFSCSFPG CSKQYDKACR LKIHLRSHTG ERPFLCDFDG CGWNFTSMSK LLRHKRKHDD
     DRRFMCPVEG CGKSFTRAEH LKGHSITHLG TKPFVCPVAG CCARFSARSS LYIHSKKHLQ
     DVDTWKSRCP ISSCNKLFTS KHSMKTHMVK RHKVGQDLLA QLEAANSLTP SSELTSQRQN
     DLSDAEIVSL FSDVPDSTSA ALLDTALVNS GILTIDVASV SSTLAGHLPA NNNNSVGQAV
     DPPSLMATSD PPQSLDTSLF FGTAATGFQQ SSLNMDEVSS VSVGPLGSLD SLAMKNSSPE
     PQALTPSSKL TVDTDALTPS STLCENSVSE LLTPTKAEWN VHPDSDFFGQ EGETQFGFPN
     AAGNHGSQKE TDLITVTGSS FLV
 
 
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