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ZXDC_MOUSE
ID   ZXDC_MOUSE              Reviewed;         858 AA.
AC   Q8C8V1; Q3TEP2; Q3URC2; Q8C4U7; Q8C4Z9; Q8C8C2; Q8C8T1; Q99J65;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=Zinc finger protein ZXDC;
GN   Name=Zxdc;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC   STRAIN=C57BL/6J; TISSUE=Cerebellum, Hippocampus, Retina, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=NMRI; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cooperates with CIITA to promote transcription of MHC class I
CC       and MHC class II genes. {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Interacts with ZXDB and CIITA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q8C8V1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8C8V1-2; Sequence=VSP_026443, VSP_026444;
CC       Name=3;
CC         IsoId=Q8C8V1-3; Sequence=VSP_026441, VSP_026442;
CC       Name=4;
CC         IsoId=Q8C8V1-4; Sequence=VSP_026439, VSP_026440;
CC   -!- PTM: Sumoylated at Lys-661 with SUMO1, SUMO2 and SUMO3; sumoylation
CC       enhances the activity of the transcriptional activation domain.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZXD family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH03332.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAC31967.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAC33082.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAC38113.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK044429; BAC31914.1; -; mRNA.
DR   EMBL; AK044529; BAC31967.1; ALT_INIT; mRNA.
DR   EMBL; AK047538; BAC33082.1; ALT_FRAME; mRNA.
DR   EMBL; AK080307; BAC37873.1; -; mRNA.
DR   EMBL; AK081005; BAC38113.1; ALT_INIT; mRNA.
DR   EMBL; AK141613; BAE24766.1; -; mRNA.
DR   EMBL; AK169517; BAE41206.1; -; mRNA.
DR   EMBL; BC003332; AAH03332.1; ALT_FRAME; mRNA.
DR   CCDS; CCDS20358.1; -. [Q8C8V1-1]
DR   CCDS; CCDS51848.1; -. [Q8C8V1-2]
DR   RefSeq; NP_084536.2; NM_030260.3. [Q8C8V1-2]
DR   RefSeq; NP_766590.1; NM_173002.3. [Q8C8V1-1]
DR   AlphaFoldDB; Q8C8V1; -.
DR   SMR; Q8C8V1; -.
DR   STRING; 10090.ENSMUSP00000074619; -.
DR   iPTMnet; Q8C8V1; -.
DR   PhosphoSitePlus; Q8C8V1; -.
DR   MaxQB; Q8C8V1; -.
DR   PaxDb; Q8C8V1; -.
DR   PRIDE; Q8C8V1; -.
DR   ProteomicsDB; 275250; -. [Q8C8V1-1]
DR   ProteomicsDB; 275251; -. [Q8C8V1-2]
DR   ProteomicsDB; 275252; -. [Q8C8V1-3]
DR   ProteomicsDB; 275253; -. [Q8C8V1-4]
DR   Antibodypedia; 33073; 111 antibodies from 20 providers.
DR   DNASU; 80292; -.
DR   Ensembl; ENSMUST00000045740; ENSMUSP00000036329; ENSMUSG00000034430. [Q8C8V1-3]
DR   Ensembl; ENSMUST00000075117; ENSMUSP00000074619; ENSMUSG00000034430. [Q8C8V1-1]
DR   Ensembl; ENSMUST00000113539; ENSMUSP00000109167; ENSMUSG00000034430. [Q8C8V1-2]
DR   GeneID; 80292; -.
DR   KEGG; mmu:80292; -.
DR   UCSC; uc009cxf.2; mouse. [Q8C8V1-1]
DR   UCSC; uc012eoy.1; mouse. [Q8C8V1-2]
DR   CTD; 79364; -.
DR   MGI; MGI:1933108; Zxdc.
DR   VEuPathDB; HostDB:ENSMUSG00000034430; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000162216; -.
DR   HOGENOM; CLU_007312_0_0_1; -.
DR   InParanoid; Q8C8V1; -.
DR   OMA; QCIQIPV; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q8C8V1; -.
DR   TreeFam; TF330996; -.
DR   BioGRID-ORCS; 80292; 2 hits in 72 CRISPR screens.
DR   PRO; PR:Q8C8V1; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q8C8V1; protein.
DR   Bgee; ENSMUSG00000034430; Expressed in ascending aorta and 244 other tissues.
DR   ExpressionAtlas; Q8C8V1; baseline and differential.
DR   Genevisible; Q8C8V1; MM.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0070742; F:C2H2 zinc finger domain binding; ISS:UniProtKB.
DR   GO; GO:0030275; F:LRR domain binding; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00355; ZnF_C2H2; 10.
DR   SUPFAM; SSF57667; SSF57667; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE   2: Evidence at transcript level;
KW   Activator; Alternative splicing; Isopeptide bond; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Ubl conjugation; Zinc; Zinc-finger.
FT   CHAIN           1..858
FT                   /note="Zinc finger protein ZXDC"
FT                   /id="PRO_0000292804"
FT   ZN_FING         176..200
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         209..233
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         239..263
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         269..291
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         298..322
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         329..353
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         359..383
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         389..413
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         419..443
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         452..477
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          142..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          624..652
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          671..714
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          727..751
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..69
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        677..713
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        727..746
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        661
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO)"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         356..363
FT                   /note="ERPFICDS -> MSCSVHLM (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_026439"
FT   VAR_SEQ         364..858
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_026440"
FT   VAR_SEQ         505..512
FT                   /note="SELTNIDL -> RKWGLSKN (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_026441"
FT   VAR_SEQ         513..858
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_026442"
FT   VAR_SEQ         712
FT                   /note="E -> V (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:16141072"
FT                   /id="VSP_026443"
FT   VAR_SEQ         713..858
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:16141072"
FT                   /id="VSP_026444"
FT   CONFLICT        154
FT                   /note="L -> Q (in Ref. 1; BAE24766)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        576
FT                   /note="P -> R (in Ref. 1; BAC38113)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        608
FT                   /note="G -> V (in Ref. 1; BAC37873)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   858 AA;  90755 MW;  A7B31AFE64907C3B CRC64;
     MDLPAVLAAP ATRGDQHGGG PSRLRRGAGP SLGAGPGRRR LLLLRGPEDG GPGPRPEEAP
     GPSPPPPEDG GDSFVVLLEV PRAADTHGQE EAEPDSGASP TEQVPAAAPG AALAGTVTIH
     NQDLLVRFDR GVFTLAAAPA PAAPSLHPAT TPGLEPSSAA ASRRGPVAAS AGSPAYRCPE
     PQCALSFAKK HQLKVHLLTH GSLQGRRPFK CPLDGCGWAF TTSYKLKRHL QSHDKLRPFS
     CPVGGCGKKF TTVYNLKAHM KGHEQESLFK CEVCAERFPT HAKLNSHQRS HFEPERPYKC
     DFPGCEKTFI TVSALFSHNR AHFREQELFS CSFPGCNKQY DKACRLKIHL RSHTGERPFI
     CDSDSCGWTF TSMSKLLRHK RKHDDDRRFT CPVEGCGKSF TRAEHLKGHS ITHLGTKPFE
     CPVEGCCARF SARSSLYIHS KKHLQDVGTP KSRCPVSSCN RLFTSKHSMK AHVVRQHSRR
     QDLVPQLEAP SSLTPSSELS SPGQSELTNI DLAALFSDTP ANSSSSTAGS DEALNSGILT
     IDVTSVSSSL GGNLPTNNNS LGPMDPLVLV AHGDMPPSLD SPLVLGTSAT VLQPGSFSAD
     DSQAMSTGAV GCLVALPVRN LNQDSPALTP SNNLTAPGTT PTSSDTTQET GSVPDLLVPI
     KVEQDLSPVP DVVQGQKESH GPSQSVLSSS TERPGAQKDS ELSAGTGSLY LESGGSARTD
     YRAIQLVKKK KQKGTGSDEG ASDSAHRKVK GGTINPPHVH SGQHSCFCGT LMVPSGGLTV
     PAPAAGLQCV QIPVLQDDPS GEGGLPLGLS PQRSAFHPYF TVDLPVYVLQ EVLPAPGGFA
     GLETAQVPGS TINLRDLE
 
 
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