ID   CCA_SCHMA               Reviewed;         347 AA.
AC   O02197;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Circulating cathodic antigen;
DE            Short=CCA;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Egyptian;
RX   PubMed=10413050; DOI=10.1016/s0166-6851(99)00068-7;
RA   Abdeen H.H., Attallah A.F., Mansour M.M., Harrison R.A.;
RT   "Molecular cloning and characterization of the polypeptide backbone of
RT   Schistosoma mansoni circulating cathodic antigen.";
RL   Mol. Biochem. Parasitol. 101:149-159(1999).
RN   [2]
RP   GLYCOSYLATION, AND STRUCTURE OF CARBOHYDRATES.
RC   STRAIN=Puerto Rican;
RX   PubMed=7925469; DOI=10.1111/j.1432-1033.1994.00467.x;
RA   Van Dam G.J., Bergwerff A.A., Thomas-Oates J.E., Rotmans J.P.,
RA   Kamerling J.P., Vliegenthart J.F.G., Deelder A.M.;
RT   "The immunologically reactive O-linked polysaccharide chains derived from
RT   circulating cathodic antigen isolated from the human blood fluke
RT   Schistosoma mansoni have Lewis x as repeating unit.";
RL   Eur. J. Biochem. 225:467-482(1994).
CC   -!- FUNCTION: Involved in protection of the schistosome gut.
CC   -!- PTM: O-glycosylated. {ECO:0000269|PubMed:7925469}.
CC   -!- SIMILARITY: Belongs to the SIKE family. {ECO:0000305}.
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DR   EMBL; U94619; AAB53003.1; -; mRNA.
DR   AlphaFoldDB; O02197; -.
DR   SMR; O02197; -.
DR   STRING; 6183.Smp_211120.1; -.
DR   GlyConnect; 95; 6 O-Linked glycans.
DR   ABCD; O02197; 1 sequenced antibody.
DR   eggNOG; ENOG502QSAD; Eukaryota.
DR   HOGENOM; CLU_812144_0_0_1; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   InterPro; IPR008555; SIKE.
DR   PANTHER; PTHR12186; PTHR12186; 1.
DR   Pfam; PF05769; SIKE; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Glycoprotein; Reference proteome.
FT   CHAIN           1..347
FT                   /note="Circulating cathodic antigen"
FT                   /id="PRO_0000089393"
FT   REGION          149..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          76..109
FT                   /evidence="ECO:0000255"
FT   COILED          206..233
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        151..177
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        303..322
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   347 AA;  39008 MW;  A8A75C7D561B7312 CRC64;
     MTFDFMLKYS FDKVMDDVQL LVSRLRAREE SVDILRQQLC KLQAQLLSMR QCQETILEFD
     EFSKRVSNQP KGPLIICLAA ENKQLEQLKI ENKTLRNSLD EHQTALDMIM TKYRGQISKL
     MRTYQVEHLV QSVINPDNNE NRCIKSFYPG PKSVNTPSTN SIDSQSVSQK SNSGKVDEIT
     DGISQSLTEQ FTTVASIVRD VTDRGDAYAT ELEEELHRLR SENAGLREIL MISSDCCPDT
     NSNDCVLPPV SLPNKDSIQH ESSSLSSIQS GRFHFLDEDS SSIHLPGIDE CLSSVNVNED
     SFLYNIPNPS DDSSNSGTIS GNHSDEDSDE DDNTVYEVAM NQMINSL