ID   CCCA_ARTBC              Reviewed;         279 AA.
AC   D4B5N6;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Vacuolar iron transporter cccA {ECO:0000303|PubMed:26960149};
GN   Name=cccA {ECO:0000303|PubMed:26960149}; ORFNames=ARB_03795;
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371;
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
RN   [2]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=26960149; DOI=10.1371/journal.pone.0150701;
RA   Kroeber A., Scherlach K., Hortschansky P., Shelest E., Staib P.,
RA   Kniemeyer O., Brakhage A.A.;
RT   "HapX mediates iron homeostasis in the pathogenic dermatophyte Arthroderma
RT   benhamiae but is dispensable for virulence.";
RL   PLoS ONE 11:E0150701-E0150701(2016).
CC   -!- FUNCTION: Vacuolar iron transporter involved in the transfer of iron
CC       from the cytosol to the vacuole for intracellular iron storage
CC       (PubMed:26960149). Plays an essential role in iron detoxification
CC       during high iron conditions (PubMed:26960149).
CC       {ECO:0000305|PubMed:26960149}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is repressed in iron starvation conditions and
CC       induced in high iron conditions and is controled by the hapX and sreA
CC       iron acquisition regulators (PubMed:26960149).
CC       {ECO:0000269|PubMed:26960149}.
CC   -!- SIMILARITY: Belongs to the CCC1 family. {ECO:0000305}.
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DR   EMBL; ABSU01000046; EFE29352.1; -; Genomic_DNA.
DR   RefSeq; XP_003009997.1; XM_003009951.1.
DR   AlphaFoldDB; D4B5N6; -.
DR   SMR; D4B5N6; -.
DR   STRING; 663331.D4B5N6; -.
DR   EnsemblFungi; EFE29352; EFE29352; ARB_03795.
DR   GeneID; 9525344; -.
DR   KEGG; abe:ARB_03795; -.
DR   eggNOG; KOG4473; Eukaryota.
DR   HOGENOM; CLU_038957_0_2_1; -.
DR   OMA; GYIKTCV; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:EnsemblFungi.
DR   GO; GO:0005384; F:manganese ion transmembrane transporter activity; IEA:EnsemblFungi.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:EnsemblFungi.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:EnsemblFungi.
DR   GO; GO:0030026; P:cellular manganese ion homeostasis; IEA:EnsemblFungi.
DR   InterPro; IPR008217; Ccc1_fam.
DR   PANTHER; PTHR31851; PTHR31851; 1.
DR   Pfam; PF01988; VIT1; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Vacuole.
FT   CHAIN           1..279
FT                   /note="Vacuolar iron transporter cccA"
FT                   /id="PRO_0000444416"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   279 AA;  29779 MW;  C3998B58768F5D04 CRC64;
     MLGGRHSHWS PQDLEEQAFS PYGTFPPSPT ESTETSSSIS STRPRVNPRI VSDAILGLSD
     GLTVPFALSA GLSALGNSRV VVVGGLAELV AGAISMGLGG YVGSRSEVES YEATVRETKH
     LVKASPMETM NIIHQVFAPY NLPEEPVARM SHILYNSPEK LLDFLLTFYH KESKPGCHQA
     WISAITLALG YFIGGFIPLI PYFMVDQVLV ALYYSIGIMI FTLLVFGYVK TCVVRGWTGK
     ENIVAGIKGG LQMVVVGGLA AGASIALARA INPTGGALF