CCD14_HUMAN
ID CCD14_HUMAN Reviewed; 953 AA.
AC Q49A88; B7Z2Q3; B7Z2T2; B8ZZ41; B8ZZ58; D3DN98; Q7Z3N3; Q86T30; Q8IWF8;
AC Q8WUJ8; Q96K47; Q9H9A3; Q9UFH0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Coiled-coil domain-containing protein 14;
GN Name=CCDC14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 537-953 (ISOFORMS 1/2/3/5/6), AND VARIANT
RP PRO-365.
RC TISSUE=Bone marrow, Retina, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 20-953 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE
RP MRNA] OF 153-953 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF
RP 584-953 (ISOFORMS 2/3/5/6), AND VARIANT PRO-365.
RC TISSUE=Brain, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 743-953 (ISOFORM 1/2/3/5/6), AND VARIANT PRO-365.
RC TISSUE=Kidney, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124; SER-670; SER-754 AND
RP SER-798, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8]
RP FUNCTION, INTERACTION WITH CEP63, AND SUBCELLULAR LOCATION.
RX PubMed=24613305; DOI=10.1016/j.cub.2014.01.067;
RA Firat-Karalar E.N., Rauniyar N., Yates J.R. III, Stearns T.;
RT "Proximity interactions among centrosome components identify regulators of
RT centriole duplication.";
RL Curr. Biol. 24:664-670(2014).
RN [9]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=26297806; DOI=10.7554/elife.07519;
RA Kodani A., Yu T.W., Johnson J.R., Jayaraman D., Johnson T.L., Al-Gazali L.,
RA Sztriha L., Partlow J.N., Kim H., Krup A.L., Dammermann A., Krogan N.,
RA Walsh C.A., Reiter J.F.;
RT "Centriolar satellites assemble centrosomal microcephaly proteins to
RT recruit CDK2 and promote centriole duplication.";
RL Elife 4:0-0(2015).
CC -!- FUNCTION: Negatively regulates centriole duplication. Negatively
CC regulates CEP63 and CDK2 centrosomal localization.
CC {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}.
CC -!- SUBUNIT: Interacts with CEP63. {ECO:0000269|PubMed:24613305}.
CC -!- INTERACTION:
CC Q49A88; Q96MT8: CEP63; NbExp=5; IntAct=EBI-751035, EBI-741977;
CC Q49A88; P43364-2: MAGEA11; NbExp=3; IntAct=EBI-751035, EBI-10178634;
CC Q49A88; Q15154: PCM1; NbExp=6; IntAct=EBI-751035, EBI-741421;
CC Q49A88; P50542: PEX5; NbExp=3; IntAct=EBI-751035, EBI-597835;
CC Q49A88-3; Q96MT8-3: CEP63; NbExp=3; IntAct=EBI-12105646, EBI-11522539;
CC Q49A88-3; P48730: CSNK1D; NbExp=3; IntAct=EBI-12105646, EBI-751621;
CC Q49A88-3; P26196: DDX6; NbExp=3; IntAct=EBI-12105646, EBI-351257;
CC Q49A88-3; P06396: GSN; NbExp=3; IntAct=EBI-12105646, EBI-351506;
CC Q49A88-3; P01112: HRAS; NbExp=3; IntAct=EBI-12105646, EBI-350145;
CC Q49A88-3; O60341: KDM1A; NbExp=3; IntAct=EBI-12105646, EBI-710124;
CC Q49A88-3; P43364: MAGEA11; NbExp=3; IntAct=EBI-12105646, EBI-739552;
CC Q49A88-3; O15481: MAGEB4; NbExp=3; IntAct=EBI-12105646, EBI-751857;
CC Q49A88-3; Q96T60: PNKP; NbExp=3; IntAct=EBI-12105646, EBI-1045072;
CC Q49A88-3; O76064: RNF8; NbExp=3; IntAct=EBI-12105646, EBI-373337;
CC Q49A88-3; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-12105646, EBI-6116822;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriolar satellite {ECO:0000269|PubMed:24613305,
CC ECO:0000269|PubMed:26297806}. Note=Colocalizes with PCM1 at centriolar
CC satellites throughout the cell cycle. {ECO:0000269|PubMed:26297806}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q49A88-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q49A88-2; Sequence=VSP_033455;
CC Name=3;
CC IsoId=Q49A88-3; Sequence=VSP_033456, VSP_033457;
CC Name=4;
CC IsoId=Q49A88-4; Sequence=VSP_033455, VSP_033459, VSP_033460;
CC Name=5;
CC IsoId=Q49A88-5; Sequence=VSP_033458;
CC Name=6;
CC IsoId=Q49A88-6; Sequence=VSP_039080;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14329.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB55229.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAH11939.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BX537652; CAD97804.1; -; mRNA.
DR EMBL; AL122079; CAB59254.1; -; mRNA.
DR EMBL; AL833312; CAD91162.1; -; mRNA.
DR EMBL; AK022954; BAB14329.1; ALT_INIT; mRNA.
DR EMBL; AK027607; BAB55229.1; ALT_INIT; mRNA.
DR EMBL; AK294979; BAH11939.1; ALT_INIT; mRNA.
DR EMBL; AK295091; BAH11968.1; -; mRNA.
DR EMBL; AC117381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79430.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79434.1; -; Genomic_DNA.
DR EMBL; BC020246; AAH20246.1; -; mRNA.
DR EMBL; BC040285; AAH40285.1; -; mRNA.
DR EMBL; BC042613; AAH42613.1; -; mRNA.
DR CCDS; CCDS77806.1; -. [Q49A88-2]
DR RefSeq; NP_001295246.1; NM_001308317.1. [Q49A88-2]
DR RefSeq; NP_073594.4; NM_022757.4.
DR RefSeq; XP_005247767.1; XM_005247710.4.
DR RefSeq; XP_005247768.1; XM_005247711.4. [Q49A88-5]
DR RefSeq; XP_005247770.1; XM_005247713.2. [Q49A88-2]
DR RefSeq; XP_005247771.1; XM_005247714.2.
DR RefSeq; XP_016862545.1; XM_017007056.1.
DR RefSeq; XP_016862547.1; XM_017007058.1.
DR RefSeq; XP_016862548.1; XM_017007059.1.
DR AlphaFoldDB; Q49A88; -.
DR SMR; Q49A88; -.
DR BioGRID; 122281; 134.
DR DIP; DIP-47727N; -.
DR IntAct; Q49A88; 66.
DR MINT; Q49A88; -.
DR STRING; 9606.ENSP00000420180; -.
DR iPTMnet; Q49A88; -.
DR PhosphoSitePlus; Q49A88; -.
DR BioMuta; CCDC14; -.
DR DMDM; 296439419; -.
DR EPD; Q49A88; -.
DR jPOST; Q49A88; -.
DR MassIVE; Q49A88; -.
DR MaxQB; Q49A88; -.
DR PaxDb; Q49A88; -.
DR PeptideAtlas; Q49A88; -.
DR PRIDE; Q49A88; -.
DR ProteomicsDB; 62026; -. [Q49A88-1]
DR ProteomicsDB; 62027; -. [Q49A88-2]
DR ProteomicsDB; 62028; -. [Q49A88-3]
DR ProteomicsDB; 62029; -. [Q49A88-4]
DR ProteomicsDB; 62030; -. [Q49A88-5]
DR ProteomicsDB; 62031; -. [Q49A88-6]
DR Antibodypedia; 32961; 56 antibodies from 15 providers.
DR DNASU; 64770; -.
DR Ensembl; ENST00000485727.5; ENSP00000418002.1; ENSG00000175455.16. [Q49A88-2]
DR Ensembl; ENST00000488653.6; ENSP00000420180.3; ENSG00000175455.16. [Q49A88-6]
DR Ensembl; ENST00000489746.5; ENSP00000418403.1; ENSG00000175455.16. [Q49A88-2]
DR GeneID; 64770; -.
DR KEGG; hsa:64770; -.
DR UCSC; uc003egx.5; human. [Q49A88-1]
DR CTD; 64770; -.
DR DisGeNET; 64770; -.
DR GeneCards; CCDC14; -.
DR HGNC; HGNC:25766; CCDC14.
DR HPA; ENSG00000175455; Low tissue specificity.
DR MIM; 617147; gene.
DR neXtProt; NX_Q49A88; -.
DR OpenTargets; ENSG00000175455; -.
DR PharmGKB; PA134990564; -.
DR VEuPathDB; HostDB:ENSG00000175455; -.
DR eggNOG; ENOG502R84N; Eukaryota.
DR GeneTree; ENSGT00390000017916; -.
DR HOGENOM; CLU_015403_0_0_1; -.
DR InParanoid; Q49A88; -.
DR OMA; CDGSFLN; -.
DR OrthoDB; 164484at2759; -.
DR PhylomeDB; Q49A88; -.
DR TreeFam; TF332390; -.
DR PathwayCommons; Q49A88; -.
DR SignaLink; Q49A88; -.
DR BioGRID-ORCS; 64770; 10 hits in 1079 CRISPR screens.
DR ChiTaRS; CCDC14; human.
DR GenomeRNAi; 64770; -.
DR Pharos; Q49A88; Tdark.
DR PRO; PR:Q49A88; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q49A88; protein.
DR Bgee; ENSG00000175455; Expressed in pancreatic ductal cell and 180 other tissues.
DR ExpressionAtlas; Q49A88; baseline and differential.
DR Genevisible; Q49A88; HS.
DR GO; GO:0034451; C:centriolar satellite; IDA:UniProtKB.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0071539; P:protein localization to centrosome; IMP:UniProtKB.
DR GO; GO:0021762; P:substantia nigra development; HEP:UniProtKB.
DR InterPro; IPR029343; CCDC14.
DR PANTHER; PTHR22367; PTHR22367; 1.
DR Pfam; PF15254; CCDC14; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..953
FT /note="Coiled-coil domain-containing protein 14"
FT /id="PRO_0000333043"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 52..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 383..413
FT /evidence="ECO:0000255"
FT COILED 483..618
FT /evidence="ECO:0000255"
FT COMPBIAS 1..19
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 124
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 670
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 754
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 798
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..200
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_033455"
FT VAR_SEQ 1..160
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_033456"
FT VAR_SEQ 125..166
FT /note="GSETAYLENRSNSRPLESKRYGSKKKRHEKHTIPLVVQKETS -> A (in
FT isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039080"
FT VAR_SEQ 161..166
FT /note="VQKETS -> MPMESA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_033457"
FT VAR_SEQ 290..448
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033458"
FT VAR_SEQ 642..655
FT /note="TLQTSMAKLLSDLS -> KQKMHLKNFPEHLI (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_033459"
FT VAR_SEQ 656..953
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_033460"
FT VARIANT 365
FT /note="T -> P (in dbSNP:rs17310144)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT /id="VAR_043116"
FT CONFLICT 154
FT /note="K -> E (in Ref. 2; BAH11939)"
FT /evidence="ECO:0000305"
FT CONFLICT 403
FT /note="K -> R (in Ref. 1; CAD97804)"
FT /evidence="ECO:0000305"
FT CONFLICT 580
FT /note="I -> T (in Ref. 5; AAH42613)"
FT /evidence="ECO:0000305"
FT CONFLICT 585
FT /note="Q -> H (in Ref. 2; BAH11968)"
FT /evidence="ECO:0000305"
FT CONFLICT 689
FT /note="S -> P (in Ref. 2; BAH11968)"
FT /evidence="ECO:0000305"
FT CONFLICT 790
FT /note="K -> E (in Ref. 5; AAH42613)"
FT /evidence="ECO:0000305"
FT CONFLICT 821
FT /note="K -> E (in Ref. 2; BAB14329)"
FT /evidence="ECO:0000305"
FT CONFLICT 886
FT /note="C -> G (in Ref. 5; AAH42613)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 953 AA; 106302 MW; 3B4335D2641E476A CRC64;
MKRGIRRDPF RKRKLGGRAK KVREPTAVNS FYREASLPSV WASLRRREMV RSGARPGQVL
SSGRHTGPAK LTNGKKATYL RKIPRFNADS GYSIHSDSES QAETVHGLDG CASLLRDILR
NEDSGSETAY LENRSNSRPL ESKRYGSKKK RHEKHTIPLV VQKETSSSDN KKQIPNEASA
RSERDTSDLE QNWSLQDHYR MYSPIIYQAL CEHVQTQMSL MNDLTSKNIP NGIPAVPCHA
PSHSESQATP HSSYGLCTST PVWSLQRPPC PPKVHSEVQT DGNSQFASQG KTVSATCTDV
LRNSFNTSPG VPCSLPKTDI SAIPTLQQLG LVNGILPQQG IHKETDLLKC IQTYLSLFRS
HGKETHLDSQ THRSPTQSQP AFLATNEEKC AREQIREATS ERKDLNIHVR DTKTVKDVQK
AKNVNKTAEK VRIIKYLLGE LKALVAEQED SEIQRLITEM EACISVLPTV SGNTDIQVEI
ALAMQPLRSE NAQLRRQLRI LNQQLREQQK TQKPSGAVDC NLELFSLQSL NMSLQNQLEE
SLKSQELLQS KNEELLKVIE NQKDENKKFS SIFKDKDQTI LENKQQYDIE ITRIKIELEE
ALVNVKSSQF KLETAEKENQ ILGITLRQRD AEVTRLRELT RTLQTSMAKL LSDLSVDSAR
CKPGNNLTKS LLNIHDKQLQ HDPAPAHTSI MSYLNKLETN YSFTHSEPLS TIKNEETIEP
DKTYENVLSS RGPQNSNTRG MEEASAPGII SALSKQDSDE GSETMALIED EHNLDNTIYI
PFARSTPEKK SPLSKRLSPQ PQIRAATTQL VSNSGLAVSG KENKLCTPVI CSSSTKEAED
APEKLSRASD MKDTQLLKKI KEAIGKIPAA TKEPEEQTAC HGPSGCLSNS LQVKGNTVCD
GSVFTSDLMS DWSISSFSTF TSRDEQDFRN GLAALDANIA RLQKSLRTGL LEK
