CCD14_MOUSE
ID CCD14_MOUSE Reviewed; 934 AA.
AC Q8K2J4; Q8BJ89;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Coiled-coil domain-containing protein 14;
GN Name=Ccdc14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-934.
RC STRAIN=C57BL/6J; TISSUE=Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-934.
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Negatively regulates centriole duplication. Negatively
CC regulates CEP63 and CDK2 centrosomal localization.
CC {ECO:0000250|UniProtKB:Q49A88}.
CC -!- SUBUNIT: Interacts with CEP63. {ECO:0000250|UniProtKB:Q49A88}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriolar satellite
CC {ECO:0000250|UniProtKB:Q49A88}. Note=Colocalizes with PCM1 at
CC centriolar satellites throughout the cell cycle.
CC {ECO:0000250|UniProtKB:Q49A88}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH31204.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH31204.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};
CC Sequence=BAC41158.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC154456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK090294; BAC41158.1; ALT_INIT; mRNA.
DR EMBL; BC031204; AAH31204.1; ALT_SEQ; mRNA.
DR CCDS; CCDS49837.1; -.
DR RefSeq; NP_766412.2; NM_172824.3.
DR AlphaFoldDB; Q8K2J4; -.
DR SMR; Q8K2J4; -.
DR BioGRID; 232132; 2.
DR STRING; 10090.ENSMUSP00000023532; -.
DR iPTMnet; Q8K2J4; -.
DR PhosphoSitePlus; Q8K2J4; -.
DR EPD; Q8K2J4; -.
DR MaxQB; Q8K2J4; -.
DR PaxDb; Q8K2J4; -.
DR PRIDE; Q8K2J4; -.
DR ProteomicsDB; 265590; -.
DR Antibodypedia; 32961; 56 antibodies from 15 providers.
DR DNASU; 239839; -.
DR Ensembl; ENSMUST00000023532; ENSMUSP00000023532; ENSMUSG00000022833.
DR GeneID; 239839; -.
DR KEGG; mmu:239839; -.
DR UCSC; uc007zba.2; mouse.
DR CTD; 64770; -.
DR MGI; MGI:2443448; Ccdc14.
DR VEuPathDB; HostDB:ENSMUSG00000022833; -.
DR eggNOG; ENOG502R84N; Eukaryota.
DR GeneTree; ENSGT00390000017916; -.
DR HOGENOM; CLU_015403_0_0_1; -.
DR InParanoid; Q8K2J4; -.
DR OMA; CDGSFLN; -.
DR OrthoDB; 164484at2759; -.
DR PhylomeDB; Q8K2J4; -.
DR TreeFam; TF332390; -.
DR BioGRID-ORCS; 239839; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Ccdc14; mouse.
DR PRO; PR:Q8K2J4; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8K2J4; protein.
DR Bgee; ENSMUSG00000022833; Expressed in secondary oocyte and 127 other tissues.
DR ExpressionAtlas; Q8K2J4; baseline and differential.
DR Genevisible; Q8K2J4; MM.
DR GO; GO:0034451; C:centriolar satellite; ISO:MGI.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0071539; P:protein localization to centrosome; ISO:MGI.
DR InterPro; IPR029343; CCDC14.
DR PANTHER; PTHR22367; PTHR22367; 1.
DR Pfam; PF15254; CCDC14; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..934
FT /note="Coiled-coil domain-containing protein 14"
FT /id="PRO_0000333044"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 852..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 432..606
FT /evidence="ECO:0000255"
FT MOD_RES 123
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q49A88"
FT MOD_RES 656
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q49A88"
FT MOD_RES 737
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q49A88"
FT MOD_RES 781
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q49A88"
FT CONFLICT 18
FT /note="R -> G (in Ref. 2; BAC41158)"
FT /evidence="ECO:0000305"
FT CONFLICT 103
FT /note="T -> I (in Ref. 3; AAH31204)"
FT /evidence="ECO:0000305"
FT CONFLICT 154
FT /note="H -> Y (in Ref. 3; AAH31204)"
FT /evidence="ECO:0000305"
FT CONFLICT 176
FT /note="A -> V (in Ref. 3; AAH31204)"
FT /evidence="ECO:0000305"
FT CONFLICT 250..252
FT /note="PSA -> ST (in Ref. 3; AAH31204)"
FT /evidence="ECO:0000305"
FT CONFLICT 324
FT /note="T -> A (in Ref. 3; AAH31204)"
FT /evidence="ECO:0000305"
FT CONFLICT 336
FT /note="E -> G (in Ref. 2; BAC41158)"
FT /evidence="ECO:0000305"
FT CONFLICT 494
FT /note="R -> H (in Ref. 3; AAH31204)"
FT /evidence="ECO:0000305"
FT CONFLICT 649
FT /note="M -> V (in Ref. 3; AAH31204)"
FT /evidence="ECO:0000305"
FT CONFLICT 768
FT /note="N -> S (in Ref. 3; AAH31204)"
FT /evidence="ECO:0000305"
FT CONFLICT 803
FT /note="G -> R (in Ref. 3; AAH31204)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 934 AA; 102630 MW; 049CB342DF688A66 CRC64;
MSPGGPRPSS RKRKLRGRDK GGPDISAVNS FFLKYSFPYA WALLRLREMV RSGSRPGQVI
SSGRQPGAKL PNGKKGTHVR KIAHFNVDSA CPVQSDSESQ TDTLQGLDGC ASLLRDILKN
EDSGSEMVYS ENRCNSKPLE GRKNRSKKKG PEKHVPSVVR KEILSSENRK WISNEASTGS
DTAQRWSLQD HYRMYSPIIY QALCEHVQTQ MSLMNSLALK NGPNGIHAVC HTMSNSGSQA
TPHSGFGCSP SASVWPPQQP SCPLMVHSEV QTDADNQFES QSQATSVKYG DVPRDPFSVH
PGVACGLPHA DSPAVAKSRQ LDLTSCILPQ QRAPKEAELL KCFQTHTSLF PAHGKDALSD
SQAYQSPSQL QPAFLATNEE KCAKEQFEEA TNEGKHLSTH VQDAKIAKNV QQAENVSQTA
EKIRLAKCLL GELKALMEED SEVQRLVTEV EACVSGLSAV SGHPNVEVEI ALALQPLRSE
NAQLRRQLRI LNQRLREQEK TEKGPGNLEL FSLQSLNMSL QNQLQESLKS QELLQSKNEE
LLKVIENQKE ENKKFTTLFK DKEQTLLHNK QQFDIEMTRV KMELEEALAN EKNLRFKLET
AEKESQILGI TLRQRDAEVA RLRELTRTLQ SSMAKLLSDL SMDTARCRMG NSLTKSLLNV
YDQQLQQDPA PAQTSIMSYL NKLETNHSFI HSKLLNNEAA IEPDRLCESV LPPQRPPHSD
AGTADGGSAS GTVSAASVED SDMDCETLTV IEDGCNVDST VYIPFARNTS KKHSPLCKRL
SPQPKLSVAA AQLVSGSAQT SKGESKPRAP AVCSSRNEAE DAPGDLSSTY DTEDVQLLRK
IKEAIGKIPA AAEHAKEQAT HHGPSAHPSP GVPVKGSIVP DSSFLNSDLM SDWSISSFST
FTSHDEQDFR NGLAALDANI ARLQKSLKTG LLEK
