CCD15_MOUSE
ID CCD15_MOUSE Reviewed; 810 AA.
AC Q8C9M2; Q8BQB1; Q8BRD7; Q8CBK5;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Coiled-coil domain-containing protein 15;
GN Name=Ccdc15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-707 (ISOFORM 1), AND NUCLEOTIDE SEQUENCE [LARGE
RP SCALE MRNA] OF 1-618 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Embryo, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8C9M2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C9M2-2; Sequence=VSP_028797;
CC Name=3;
CC IsoId=Q8C9M2-3; Sequence=VSP_028797, VSP_028798, VSP_028799;
CC Name=4;
CC IsoId=Q8C9M2-4; Sequence=VSP_028798, VSP_028799;
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DR EMBL; AK035850; BAC29211.1; -; mRNA.
DR EMBL; AK041803; BAC31071.1; -; mRNA.
DR EMBL; AK045055; BAC32199.1; -; mRNA.
DR EMBL; AK051119; BAC34530.1; -; mRNA.
DR EMBL; AC138284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032924; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS40584.2; -. [Q8C9M2-1]
DR RefSeq; NP_001074898.1; NM_001081429.1. [Q8C9M2-1]
DR RefSeq; XP_006510404.1; XM_006510341.3. [Q8C9M2-1]
DR AlphaFoldDB; Q8C9M2; -.
DR SMR; Q8C9M2; -.
DR BioGRID; 232850; 13.
DR IntAct; Q8C9M2; 15.
DR STRING; 10090.ENSMUSP00000036784; -.
DR iPTMnet; Q8C9M2; -.
DR PhosphoSitePlus; Q8C9M2; -.
DR EPD; Q8C9M2; -.
DR MaxQB; Q8C9M2; -.
DR PaxDb; Q8C9M2; -.
DR PRIDE; Q8C9M2; -.
DR ProteomicsDB; 281493; -. [Q8C9M2-1]
DR ProteomicsDB; 281494; -. [Q8C9M2-2]
DR ProteomicsDB; 281495; -. [Q8C9M2-3]
DR ProteomicsDB; 281496; -. [Q8C9M2-4]
DR Antibodypedia; 50022; 72 antibodies from 15 providers.
DR Ensembl; ENSMUST00000037275; ENSMUSP00000036784; ENSMUSG00000034303. [Q8C9M2-2]
DR Ensembl; ENSMUST00000213633; ENSMUSP00000150207; ENSMUSG00000034303. [Q8C9M2-1]
DR Ensembl; ENSMUST00000216042; ENSMUSP00000150095; ENSMUSG00000034303. [Q8C9M2-4]
DR Ensembl; ENSMUST00000217238; ENSMUSP00000149429; ENSMUSG00000034303. [Q8C9M2-4]
DR Ensembl; ENSMUST00000239439; ENSMUSP00000159312; ENSMUSG00000034303. [Q8C9M2-1]
DR GeneID; 245902; -.
DR KEGG; mmu:245902; -.
DR UCSC; uc009oum.1; mouse. [Q8C9M2-2]
DR UCSC; uc009oun.1; mouse. [Q8C9M2-1]
DR UCSC; uc009oup.1; mouse. [Q8C9M2-4]
DR CTD; 80071; -.
DR MGI; MGI:2444488; Ccdc15.
DR VEuPathDB; HostDB:ENSMUSG00000034303; -.
DR eggNOG; ENOG502QU35; Eukaryota.
DR GeneTree; ENSGT00500000044966; -.
DR HOGENOM; CLU_018471_0_0_1; -.
DR InParanoid; Q8C9M2; -.
DR OMA; DQDDIRN; -.
DR PhylomeDB; Q8C9M2; -.
DR TreeFam; TF329047; -.
DR BioGRID-ORCS; 245902; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Ccdc15; mouse.
DR PRO; PR:Q8C9M2; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8C9M2; protein.
DR Bgee; ENSMUSG00000034303; Expressed in animal zygote and 65 other tissues.
DR ExpressionAtlas; Q8C9M2; baseline and differential.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR InterPro; IPR037693; CCDC15.
DR PANTHER; PTHR14817; PTHR14817; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..810
FT /note="Coiled-coil domain-containing protein 15"
FT /id="PRO_0000307716"
FT COILED 65..89
FT /evidence="ECO:0000255"
FT COILED 160..189
FT /evidence="ECO:0000255"
FT COILED 638..669
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="M -> MLTSGQAFISQKSM (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028797"
FT VAR_SEQ 173..189
FT /note="LSQTMKQARHQLASFKT -> VSTGTIYFLSSCFSSVL (in isoform 3
FT and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_028798"
FT VAR_SEQ 190..810
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_028799"
SQ SEQUENCE 810 AA; 93527 MW; 4F9FDC5B2E57F327 CRC64;
MPGGMAPLKK PRNPTKLPLA LNPTKSKDVL AVLAERNQAI IPVGAWVEPA SPNWSGIPAH
TSAYVVEEEI KEQQRRKQES LRHFQRQVRH RVNQRVKLRK KQQLHKSYKA AEKEGSIAMQ
YSDLAHLSSK RTSVFPSNLN AAVGRFRLPT SQVLGDAIED GENQLFQQQA QALSQTMKQA
RHQLASFKTV SEKKTPVLPN GGRKGCPTQE GLGCGKISFV AVSEERDALF VSCQQDFLSE
DKEKAFSKVQ KVKFKNPLSV VIKEDERKQL HPHSLQAVLP EAQDYFVEVQ SGLPESQSDV
IDVQNVEPKA SRIEPKTLGV EPDTQATGVE CQTTEPEGQA VKTGIQDVPK VQTVELDGNT
ELEAQDFLPS HQAFLSRDTD CLPNCQYQDS LPKGHCVLPN YWNVLPKYQN QHFLPVDQEF
LPRNQLALPK EQNHPLQCQK QDLLPREQFP LLLRHQDQRE PHVLPKCQEH DVLSKAQNYL
HNYQEQDLQL QNQEVNSKEP LSDITDGKGR EIFSLDMFSK KPSTFMRRER GDEELPLDSP
QCAPPQIQDQ VFLREQSQQP SVRTAERWQE DLYLSGHECL PPRQRRDTCS RQQQVYEEYR
SGLSTEQQAL LAFQSGVDQE EDKKERQKQY LRHRRLFMDI EREQVKEQNR QRERKRRIEK
IKKKKEQQRY AEEQRLLRMN CHEEPYSEEK ISDVLAQLQL EEIKGAREKQ QQREKEYIRY
VEALRAQVQE KMKLYNITLP PLCCCGPDFW DAHPDTCANN CIFYKNYRAY NRALHSVINS
SDISEGNATL RNAIRNFASA HRRTPKQSLH
