CCD18_HUMAN
ID CCD18_HUMAN Reviewed; 1454 AA.
AC Q5T9S5; Q6ZU17;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Coiled-coil domain-containing protein 18;
DE AltName: Full=Sarcoma antigen NY-SAR-24;
GN Name=CCDC18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 256-1454 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1355, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5T9S5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T9S5-2; Sequence=VSP_024636;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC86410.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK126045; BAC86410.1; ALT_INIT; mRNA.
DR EMBL; AC126124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL139421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS76180.1; -. [Q5T9S5-1]
DR RefSeq; NP_001293005.1; NM_001306076.1. [Q5T9S5-1]
DR RefSeq; NP_996769.3; NM_206886.4.
DR AlphaFoldDB; Q5T9S5; -.
DR SMR; Q5T9S5; -.
DR BioGRID; 131230; 62.
DR IntAct; Q5T9S5; 35.
DR MINT; Q5T9S5; -.
DR STRING; 9606.ENSP00000383808; -.
DR iPTMnet; Q5T9S5; -.
DR PhosphoSitePlus; Q5T9S5; -.
DR BioMuta; CCDC18; -.
DR DMDM; 74745727; -.
DR EPD; Q5T9S5; -.
DR jPOST; Q5T9S5; -.
DR MassIVE; Q5T9S5; -.
DR MaxQB; Q5T9S5; -.
DR PaxDb; Q5T9S5; -.
DR PeptideAtlas; Q5T9S5; -.
DR PRIDE; Q5T9S5; -.
DR ProteomicsDB; 64812; -. [Q5T9S5-1]
DR ProteomicsDB; 64813; -. [Q5T9S5-2]
DR Antibodypedia; 33656; 50 antibodies from 11 providers.
DR DNASU; 343099; -.
DR Ensembl; ENST00000343253.11; ENSP00000343377.7; ENSG00000122483.18. [Q5T9S5-1]
DR Ensembl; ENST00000370276.6; ENSP00000359299.2; ENSG00000122483.18. [Q5T9S5-1]
DR GeneID; 343099; -.
DR KEGG; hsa:343099; -.
DR UCSC; uc057iix.1; human. [Q5T9S5-1]
DR CTD; 343099; -.
DR DisGeNET; 343099; -.
DR GeneCards; CCDC18; -.
DR HGNC; HGNC:30370; CCDC18.
DR HPA; ENSG00000122483; Tissue enhanced (bone marrow, lymphoid tissue, testis).
DR neXtProt; NX_Q5T9S5; -.
DR OpenTargets; ENSG00000122483; -.
DR PharmGKB; PA142672178; -.
DR VEuPathDB; HostDB:ENSG00000122483; -.
DR eggNOG; ENOG502QTZW; Eukaryota.
DR GeneTree; ENSGT00940000153190; -.
DR InParanoid; Q5T9S5; -.
DR OMA; TDRNMKE; -.
DR OrthoDB; 130835at2759; -.
DR PhylomeDB; Q5T9S5; -.
DR PathwayCommons; Q5T9S5; -.
DR SignaLink; Q5T9S5; -.
DR BioGRID-ORCS; 343099; 1 hit in 257 CRISPR screens.
DR ChiTaRS; CCDC18; human.
DR GenomeRNAi; 343099; -.
DR Pharos; Q5T9S5; Tdark.
DR PRO; PR:Q5T9S5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T9S5; protein.
DR Bgee; ENSG00000122483; Expressed in ventricular zone and 103 other tissues.
DR ExpressionAtlas; Q5T9S5; baseline and differential.
DR Genevisible; Q5T9S5; HS.
DR InterPro; IPR029613; Ccdc18/Sojo.
DR PANTHER; PTHR18875:SF8; PTHR18875:SF8; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..1454
FT /note="Coiled-coil domain-containing protein 18"
FT /id="PRO_0000284775"
FT REGION 828..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 107..138
FT /evidence="ECO:0000255"
FT COILED 170..402
FT /evidence="ECO:0000255"
FT COILED 438..464
FT /evidence="ECO:0000255"
FT COILED 508..1309
FT /evidence="ECO:0000255"
FT MOD_RES 45
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q640L5"
FT MOD_RES 1355
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1295..1450
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024636"
FT CONFLICT 326
FT /note="N -> T (in Ref. 1; BAC86410)"
FT /evidence="ECO:0000305"
FT CONFLICT 498
FT /note="V -> VA (in Ref. 1; BAC86410)"
FT /evidence="ECO:0000305"
FT CONFLICT 901
FT /note="L -> F (in Ref. 1; BAC86410)"
FT /evidence="ECO:0000305"
FT CONFLICT 1002
FT /note="K -> E (in Ref. 1; BAC86410)"
FT /evidence="ECO:0000305"
FT CONFLICT 1126
FT /note="Y -> C (in Ref. 1; BAC86410)"
FT /evidence="ECO:0000305"
FT CONFLICT 1135
FT /note="E -> K (in Ref. 1; BAC86410)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1454 AA; 168962 MW; 1F2FB01956059DD1 CRC64;
MESSSSDYYN KDNEEESLLA NVASLRHELK ITEWSLQSLG EELSSVSPSE NSDYAPNPSR
SEKLILDVQP SHPGLLNYSP YENVCKISGS STDFQKKPRD KMFSSSAPVD QEIKSLREKL
NKLRQQNACL VTQNHSLMTK FESIHFELTQ SRAKVSMLES AQQQAASVPI LEEQIINLEA
EVSAQDKVLR EAENKLEQSQ KMVIEKEQSL QESKEECIKL KVDLLEQTKQ GKRAERQRNE
ALYNAEELSK AFQQYKKKVA EKLEKVQAEE EILERNLTNC EKENKRLQER CGLYKSELEI
LKEKLRQLKE ENNNGKEKLR IMAVKNSEVM AQLTESRQSI LKLESELENK DEILRDKFSL
MNENRELKVR VAAQNERLDL CQQEIESSRV ELRSLEKIIS QLPLKRELFG FKSYLSKYQM
SSFSNKEDRC IGCCEANKLV ISELRIKLAI KEAEIQKLHA NLTANQLSQS LITCNDSQES
SKLSSLETEP VKLGGHQVES VKDQNQHTMN KQYEKERQRL VTGIEELRTK LIQIEAENSD
LKVNMAHRTS QFQLIQEELL EKASNSSKLE SEMTKKCSQL LTLEKQLEEK IVAYSSIAAK
NAELEQELME KNEKIRSLET NINTEHEKIC LAFEKAKKIH LEQHKEMEKQ IERLEAQLEK
KDQQFKEQEK TMSMLQQDII CKQHHLESLD RLLTESKGEM KKENMKKDEA LKALQNQVSE
ETIKVRQLDS ALEICKEELV LHLNQLEGNK EKFEKQLKKK SEEVYCLQKE LKIKNHSLQE
TSEQNVILQH TLQQQQQMLQ QETIRNGELE DTQTKLEKQV SKLEQELQKQ RESSAEKLRK
MEEKCESAAH EADLKRQKVI ELTGTARQVK IEMDQYKEEL SKMEKEIMHL KRDGENKAMH
LSQLDMILDQ TKTELEKKTN AVKELEKLQH STETELTEAL QKREVLETEL QNAHGELKST
LRQLQELRDV LQKAQLSLEE KYTTIKDLTA ELRECKMEIE DKKQELLEMD QALKERNWEL
KQRAAQVTHL DMTIREHRGE MEQKIIKLEG TLEKSELELK ECNKQIESLN DKLQNAKEQL
REKEFIMLQN EQEISQLKKE IERTQQRMKE MESVMKEQEQ YIATQYKEAI DLGQELRLTR
EQVQNSHTEL AEARHQQVQA QREIERLSSE LEDMKQLSKE KDAHGNHLAE ELGASKVREA
HLEARMQAEI KKLSAEVESL KEAYHMEMIS HQENHAKWKI SADSQKSSVQ QLNEQLEKAK
LELEEAQDTV SNLHQQVQDR NEVIEAANEA LLTKESELTR LQAKISGHEK AEDIKFLPAP
FTSPTEIMPD VQDPKFAKCF HTSFSKCTKL RRSISASDLT FKIHGDEDLS EELLQDLKKM
QLEQPSTLEE SHKNLTYTQP DSFKPLTYNL EADSSENNDF NTLSGMLRYI NKEVRLLKKS
SMQTGAGLNQ GENV
