CCD18_MOUSE
ID CCD18_MOUSE Reviewed; 1455 AA.
AC Q640L5; Q8BIM9; Q8BIN1; Q9DA43;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Coiled-coil domain-containing protein 18;
GN Name=Ccdc18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
RC STRAIN=C57BL/6J; TISSUE=Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q640L5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q640L5-2; Sequence=VSP_024642, VSP_024643;
CC Name=3;
CC IsoId=Q640L5-3; Sequence=VSP_024641;
CC Name=4;
CC IsoId=Q640L5-4; Sequence=VSP_024637, VSP_024638, VSP_024639,
CC VSP_024640;
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DR EMBL; AK040158; BAC30527.1; -; mRNA.
DR EMBL; AK040607; BAC30642.1; -; mRNA.
DR EMBL; AK006197; BAB24453.1; -; mRNA.
DR EMBL; BC082598; AAH82598.1; -; mRNA.
DR CCDS; CCDS39202.1; -. [Q640L5-1]
DR RefSeq; NP_082757.1; NM_028481.1. [Q640L5-1]
DR AlphaFoldDB; Q640L5; -.
DR SMR; Q640L5; -.
DR BioGRID; 215867; 3.
DR STRING; 10090.ENSMUSP00000036507; -.
DR iPTMnet; Q640L5; -.
DR PhosphoSitePlus; Q640L5; -.
DR EPD; Q640L5; -.
DR jPOST; Q640L5; -.
DR PaxDb; Q640L5; -.
DR PRIDE; Q640L5; -.
DR ProteomicsDB; 265705; -. [Q640L5-1]
DR ProteomicsDB; 265706; -. [Q640L5-2]
DR ProteomicsDB; 265707; -. [Q640L5-3]
DR ProteomicsDB; 265708; -. [Q640L5-4]
DR Antibodypedia; 33656; 50 antibodies from 11 providers.
DR DNASU; 73254; -.
DR Ensembl; ENSMUST00000047677; ENSMUSP00000036507; ENSMUSG00000056531. [Q640L5-1]
DR Ensembl; ENSMUST00000197718; ENSMUSP00000142963; ENSMUSG00000056531. [Q640L5-3]
DR GeneID; 73254; -.
DR KEGG; mmu:73254; -.
DR UCSC; uc008ynr.1; mouse. [Q640L5-1]
DR UCSC; uc008yns.2; mouse. [Q640L5-3]
DR CTD; 343099; -.
DR MGI; MGI:1922974; Ccdc18.
DR VEuPathDB; HostDB:ENSMUSG00000056531; -.
DR eggNOG; ENOG502QTZW; Eukaryota.
DR GeneTree; ENSGT00940000153190; -.
DR HOGENOM; CLU_004651_2_0_1; -.
DR InParanoid; Q640L5; -.
DR OMA; TDRNMKE; -.
DR OrthoDB; 130835at2759; -.
DR PhylomeDB; Q640L5; -.
DR TreeFam; TF335610; -.
DR BioGRID-ORCS; 73254; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Ccdc18; mouse.
DR PRO; PR:Q640L5; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q640L5; protein.
DR Bgee; ENSMUSG00000056531; Expressed in animal zygote and 108 other tissues.
DR Genevisible; Q640L5; MM.
DR InterPro; IPR029613; Ccdc18/Sojo.
DR PANTHER; PTHR18875:SF8; PTHR18875:SF8; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..1455
FT /note="Coiled-coil domain-containing protein 18"
FT /id="PRO_0000284776"
FT REGION 799..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 108..405
FT /evidence="ECO:0000255"
FT COILED 441..473
FT /evidence="ECO:0000255"
FT COMPBIAS 809..840
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 47
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1356
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5T9S5"
FT VAR_SEQ 1..35
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024637"
FT VAR_SEQ 36..37
FT /note="WS -> ME (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024638"
FT VAR_SEQ 158..171
FT /note="IAMLESAQEQAANI -> VCLLMGEENICNIL (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024639"
FT VAR_SEQ 172..1455
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024640"
FT VAR_SEQ 194..1455
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024641"
FT VAR_SEQ 407
FT /note="L -> D (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024642"
FT VAR_SEQ 408..1455
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024643"
SQ SEQUENCE 1455 AA; 169741 MW; EF04ACB9E4AA2472 CRC64;
MEFISSDYCT KDNDNEEESL LANVASLRHE LKITEWSLHN LGEELSSVSP SENSEYVCSP
SRSERLILEE LTQPSHLGRL IYPPYKKVCK TSDSTDYQKK SRDQVSFSSV SMDQEVKNLR
EKLHKLRQQN ACLVTQNHSL MTKIESVHFE LTQSKAKIAM LESAQEQAAN IPILEEQIIN
LEAEVSAQDK VLREAEDKLE QSQKMVIEKE HSLQEAKEEC IKLKVDLLEQ SKQGKRAERQ
RNEALYNAEE LSKAFQLYKE KVAEKLEKVQ DEEEILERNL SNCEKENKRL QEKCNLYKSE
LEILKEKFRE LKEEHYSGKE KLMIMAMKNS EVMSQLTESR QCILKLEREL EDKDEIVREK
FSLLNENREL KVRVATQNER LELCQQDIDN SRVELKSLEK LITQIPLKRE IVGFRSSLCK
HQRSSVSDKE DKCIGCCEAN KLMISELRIK LAIREAEIQK LHANLTVNQL SQNVANDSQE
CGKVNTLETE PVKLGGSQVE SIKDGDQQTV NKQYEREKQR LATGIEELRA KLTQIEAENS
DLKVNMAHRT SQFQLIQEEL LEKASNASKL ENEMTKKCSQ LLILEKQLEE KIIAYSSIAA
KNAELEQELM EKNEKIRSLE SNINTEHEKI CFAFEKAKKI HLEQHKEMEK QIEQLETQLE
KRDQQFKEQE KTMSILQQDI LCKQHHLESL DRLLTESKVE MEKENMKKDE ALKALQIHVS
EETIKVRQLD SALEICKEEL ALHLNQLERN KEKFERQLKK KSEEVYCLQK ELKIKTHNLE
ETSEQNAILQ HTLQQQQQML QQETMRNGEL EDTQSKLEKQ VSKQEQELQK QRESSTEKLR
KMEEKYETAI REVDLKRQKI IELTGTARQA KLEMDQYKEE LSKMEKEIIH LKRDGENKSM
QLSQLDMVLD QTKTELEKTT NSVKELERLQ HHTETELTET MQKREALENE LQNAHGELKS
TLRQLQELRD VLQKAQLSLE EKYTTIKDLT AELRECKMEI EDKKQELIEM DQALKERNWE
LKQRAAQVTH LDMTIREHRG EMEQKIIKLE GTLEKSELEL KECNKQVESL NEKLQNAKEQ
LREKEFIMLQ NEQEISQLKK EIERTQQRMK EMESVIKEQE DYIATQYKEV IDLGQELRLT
QEQMQNTHSE LVEARRQEVQ AQREIERLAG ELEDIKQLSK EKEAHGNRLA EELGASQVRE
AHLEARMQAE IKKLSSEVDS LKEAYQIEMI SHQENHAKWK LSAESQKTSV QQLNEQLEKA
KQELEEAQDT VSNLHQQVQD RNEVIEAANE ALLIKESELT RLQAKISGHE KTEDTKYLPA
PFTTLTEIIP DSQHPNFAKH SQISLFKCRK LRRSISASDL SFKSHGNDDL SEELLQDLKK
MQFEQTSAIE SGHKDLPLTH SESFKPLPYN LEDDSSESND FSTLSGMLRY INKEVRLLKK
SSLQTATGLS QGGKL
