ID   CCD1_LOTGI              Reviewed;         396 AA.
AC   B3A0Q3;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Coiled-coil domain-containing protein 1;
DE   AltName: Full=Aspartate-rich protein;
DE   Flags: Precursor;
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND IDENTIFICATION.
RC   TISSUE=Mantle {ECO:0000269|Ref.1};
RA   Richardson P., Lucas S., Rokhsar D., Wang M., Lindquist E.A.;
RT   "DOE Joint Genome Institute Lottia gigantea EST project.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 36-43; 49-67 AND 182-212, SUBCELLULAR LOCATION, AND
RP   TISSUE SPECIFICITY.
RC   TISSUE=Shell;
RX   PubMed=23145877; DOI=10.1111/febs.12062;
RA   Marie B., Jackson D.J., Ramos-Silva P., Zanella-Cleon I., Guichard N.,
RA   Marin F.;
RT   "The shell-forming proteome of Lottia gigantea reveals both deep
RT   conservations and lineage-specific novelties.";
RL   FEBS J. 280:214-232(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23145877}.
CC   -!- TISSUE SPECIFICITY: Component of the acid-insoluble and acid-soluble
CC       organic matrix of calcified layers of the shell (at protein level).
CC       {ECO:0000269|PubMed:23145877}.
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DR   EMBL; FC615637; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; FC628703; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; B3A0Q3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Coiled coil; Direct protein sequencing; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..396
FT                   /note="Coiled-coil domain-containing protein 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000415243"
FT   REGION          231..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          288..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          53..73
FT                   /evidence="ECO:0000255"
FT   COILED          109..129
FT                   /evidence="ECO:0000255"
FT   COILED          208..242
FT                   /evidence="ECO:0000255"
FT   COILED          287..308
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        231..257
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..378
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   396 AA;  44636 MW;  6B41790A7A9E516D CRC64;
     MAARSALCFL AIITLFVYAC GRPALNFNSI YKDSRSSVKH FPRVTDSRYA YTKIDSKLDS
     ILSELQKEQN DRDDDDDDDD EDDLFDEIND IFDDVMDDDI EEDGDDIHEV EKIEEAVDDV
     IDMIDDIIDD DADDDSDDVP EDLNDAQEDI LELIKDSNDD KNDDETSDII DDILDIVEDA
     KDADDHRPIA DIRVVESLSK PGAVAEDDKE SKKIDETVQE LLDEIKDVVE DANDDVNDIL
     DTDDEDEDED VQEEKDEDIH EDVGNVMVNL MHGVHGVTGG GVNHDIYEEI EEKMDEVDDF
     IDDAIDEHND DDVNDDENDD VYDEHDDLVD DVNDDADDDN DDADDDNDDA DDDNDDSDDN
     DDSDDDNDDD DIDDVADDVL EVIVDAVEAM NTPTNV