ID   CCD1_PLAF7              Reviewed;         319 AA.
AC   Q8IHS4; A0A144A139;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Coiled-coil domain-containing protein PF3D7_1144200;
GN   ORFNames=PF11_0455, PF3D7_1144200;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000305}
RP   SYNTHESIS OF 271-310, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX   PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA   Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA   Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA   Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT   "Rapid identification of malaria vaccine candidates based on alpha-helical
RT   coiled coil protein motif.";
RL   PLoS ONE 2:E645-E645(2007).
CC   -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC       determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR   EMBL; LN999945; CZT99105.1; -; Genomic_DNA.
DR   RefSeq; XP_001348122.1; XM_001348086.1.
DR   AlphaFoldDB; Q8IHS4; -.
DR   SMR; Q8IHS4; -.
DR   EnsemblProtists; CZT99105; CZT99105; PF3D7_1144200.
DR   GeneID; 810998; -.
DR   KEGG; pfa:PF3D7_1144200; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1144200; -.
DR   HOGENOM; CLU_981677_0_0_1; -.
DR   InParanoid; Q8IHS4; -.
DR   OMA; IMSIMNV; -.
DR   Proteomes; UP000001450; Chromosome 11.
PE   1: Evidence at protein level;
KW   Coiled coil; Merozoite; Reference proteome.
FT   CHAIN           1..319
FT                   /note="Coiled-coil domain-containing protein PF3D7_1144200"
FT                   /id="PRO_0000364020"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          100..134
FT                   /evidence="ECO:0000255"
FT   COILED          166..242
FT                   /evidence="ECO:0000255"
FT   COILED          281..310
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        24..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..134
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   319 AA;  37596 MW;  761993E03CF154B6 CRC64;
     MSEEHSNDHI EDVVLCSQNC DETNSPKNEK DEKDFKNFSS ESSDSYYKNK FRLKKNSIEI
     KKKSLLKSKL KNDDIQTIIK NDPILSKLNK TMTTDDEIFD LANKKENKTK FKLEKEKEKN
     EKKEKKEKKV TNDSTNNKNK NNSVPFLNEN QENKNQHNHN NKIKYELNEQ TYDINNISEE
     ILKKENHHTN IEYNEKVQDQ DNTLNINQKV NKIQLNSTKK QKQKEKTKKE IKLNEQNEIK
     KNNQNFNSSI LNEIKKNKEL SPLSLIKKHG RLINNIEEIY NSNCEQIQNV RDEFAELKND
     LNKIMNLINI GQKAVASLK