CCD21_ARATH
ID CCD21_ARATH Reviewed; 361 AA.
AC P42752; Q0WRQ1; Q1LYY4;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 3.
DT 25-MAY-2022, entry version 152.
DE RecName: Full=Cyclin-D2-1;
DE AltName: Full=Cyclin-delta-2;
DE Short=Cyclin-d2;
DE AltName: Full=G1/S-specific cyclin-D2-1;
DE Short=CycD2;1;
GN Name=CYCD2-1; Synonyms=CYCD2; OrderedLocusNames=At2g22490;
GN ORFNames=F14M13.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=cv. Landsberg erecta; TISSUE=Seedling;
RX PubMed=7696881; DOI=10.2307/3869840;
RA Soni R., Carmichael J.P., Shah Z.H., Murray J.A.H.;
RT "A family of cyclin D homologs from plants differentially controlled by
RT growth regulators and containing the conserved retinoblastoma protein
RT interaction motif.";
RL Plant Cell 7:85-103(1995).
RN [2]
RP SEQUENCE REVISION.
RA Murray J.A.H.;
RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP INDUCTION.
RX PubMed=10848578; DOI=10.1128/mcb.20.13.4513-4521.2000;
RA Riou-Khamlichi C., Menges M., Healy J.M.S., Murray J.A.H.;
RT "Sugar control of the plant cell cycle: differential regulation of
RT Arabidopsis D-type cyclin gene expression.";
RL Mol. Cell. Biol. 20:4513-4521(2000).
RN [8]
RP FUNCTION.
RX PubMed=10850717; DOI=10.1038/35014621;
RA Cockcroft C.E., den Boer B.G.W., Healy J.M.S., Murray J.A.H.;
RT "Cyclin D control of growth rate in plants.";
RL Nature 405:575-579(2000).
RN [9]
RP INTERACTION WITH CDKA-1.
RX PubMed=11096103; DOI=10.1074/jbc.m009074200;
RA Healy J.M.S., Menges M., Doonan J.H., Murray J.A.H.;
RT "The Arabidopsis D-type cyclins CycD2 and CycD3 both interact in vivo with
RT the PSTAIRE cyclin-dependent kinase Cdc2a but are differentially
RT controlled.";
RL J. Biol. Chem. 276:7041-7047(2001).
RN [10]
RP FUNCTION, AND INTERACTION WITH CDKA-1.
RX PubMed=11722776; DOI=10.1046/j.1365-313x.2001.01160.x;
RA Boniotti M.B., Gutierrez C.;
RT "A cell-cycle-regulated kinase activity phosphorylates plant retinoblastoma
RT protein and contains, in Arabidopsis, a CDKA/cyclin D complex.";
RL Plant J. 28:341-350(2001).
RN [11]
RP INTERACTION WITH KRP1/ICK1.
RX PubMed=12569402; DOI=10.1007/s00425-002-0935-x;
RA Zhou Y., Wang H., Gilmer S., Whitwill S., Fowke L.C.;
RT "Effects of co-expressing the plant CDK inhibitor ICK1 and D-type cyclin
RT genes on plant growth, cell size and ploidy in Arabidopsis thaliana.";
RL Planta 216:604-613(2003).
RN [12]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15208425; DOI=10.1104/pp.104.040436;
RA Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W.,
RA Ma H.;
RT "Genome-wide analysis of the cyclin family in Arabidopsis and comparative
RT phylogenetic analysis of plant cyclin-like proteins.";
RL Plant Physiol. 135:1084-1099(2004).
RN [13]
RP DEVELOPMENTAL STAGE.
RX PubMed=16517759; DOI=10.1105/tpc.105.039636;
RA Menges M., Samland A.K., Planchais S., Murray J.A.H.;
RT "The D-type cyclin CYCD3;1 is limiting for the G1-to-S-phase transition in
RT Arabidopsis.";
RL Plant Cell 18:893-906(2006).
CC -!- FUNCTION: Acts on the G1 phase of the cell cycle to control cell
CC division rate in both shoot and root meristems. The complex formed with
CC CDKA-1 phosphorylates plant retinoblastoma protein.
CC {ECO:0000269|PubMed:10850717, ECO:0000269|PubMed:11722776}.
CC -!- SUBUNIT: Interacts with KRP1/ICK1 and with the C-terminal domain of
CC CDKA-1. {ECO:0000269|PubMed:11096103, ECO:0000269|PubMed:11722776,
CC ECO:0000269|PubMed:12569402}.
CC -!- INTERACTION:
CC P42752; P24100: CDKA-1; NbExp=4; IntAct=EBI-1253160, EBI-371713;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=P42752-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in roots and leaves.
CC {ECO:0000269|PubMed:7696881}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout the cell cycle.
CC {ECO:0000269|PubMed:16517759}.
CC -!- INDUCTION: By sucrose and glucose. {ECO:0000269|PubMed:10848578,
CC ECO:0000269|PubMed:7696881}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin D subfamily.
CC {ECO:0000305}.
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DR EMBL; X83370; CAA58286.1; -; mRNA.
DR EMBL; AC006592; AAD22352.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07313.1; -; Genomic_DNA.
DR EMBL; BT025242; ABF18995.1; -; mRNA.
DR EMBL; AK228250; BAF00198.1; -; mRNA.
DR PIR; C84613; C84613.
DR RefSeq; NP_179835.1; NM_127815.4. [P42752-1]
DR AlphaFoldDB; P42752; -.
DR SMR; P42752; -.
DR BioGRID; 2135; 30.
DR IntAct; P42752; 29.
DR STRING; 3702.AT2G22490.2; -.
DR PaxDb; P42752; -.
DR EnsemblPlants; AT2G22490.1; AT2G22490.1; AT2G22490. [P42752-1]
DR GeneID; 816782; -.
DR Gramene; AT2G22490.1; AT2G22490.1; AT2G22490. [P42752-1]
DR KEGG; ath:AT2G22490; -.
DR Araport; AT2G22490; -.
DR eggNOG; KOG0656; Eukaryota.
DR HOGENOM; CLU_048040_1_1_1; -.
DR InParanoid; P42752; -.
DR OMA; TTESWII; -.
DR PhylomeDB; P42752; -.
DR PRO; PR:P42752; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; P42752; baseline and differential.
DR Genevisible; P42752; AT.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR031093; Cyclin_D2-1_plant.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR PANTHER; PTHR10177:SF440; PTHR10177:SF440; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
DR PROSITE; PS00292; CYCLINS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Cyclin;
KW Reference proteome.
FT CHAIN 1..361
FT /note="Cyclin-D2-1"
FT /id="PRO_0000080446"
FT REGION 335..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 94
FT /note="L -> S (in Ref. 6; BAF00198)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 361 AA; 40580 MW; 6D6DDC767310ED2F CRC64;
MAENLACGET SESWIIDNDD DDINYGGGFT NEIDYNHQLF AKDDNFGGNG SIPMMGSSSS
SLSEDRIKEM LVREIEFCPG TDYVKRLLSG DLDLSVRNQA LDWILKVCAH YHFGHLCICL
SMNYLDRFLT SYELPKDKDW AAQLLAVSCL SLASKMEETD VPHIVDLQVE DPKFVFEAKT
IKRMELLVVT TLNWRLQALT PFSFIDYFVD KISGHVSENL IYRSSRFILN TTKAIEFLDF
RPSEIAAAAA VSVSISGETE CIDEEKALSS LIYVKQERVK RCLNLMRSLT GEENVRGTSL
SQEQARVAVR AVPASPVGVL EATCLSYRSE ERTVESCTNS SQSSPDNNNN NNNSNKRRRK
Q