ID   CCD22_DANRE             Reviewed;         639 AA.
AC   Q4V909;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Coiled-coil domain-containing protein 22;
GN   Name=ccdc22; ORFNames=zgc:114058;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in regulation of NF-kappa-B signaling. May be
CC       involved in copper-dependent atp7a trafficking between the trans-Golgi
CC       network and vesicles in the cell periphery (By similarity).
CC       {ECO:0000250|UniProtKB:O60826}.
CC   -!- SIMILARITY: Belongs to the CCDC22 family. {ECO:0000305}.
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DR   EMBL; BC097121; AAH97121.1; -; mRNA.
DR   RefSeq; NP_001020656.1; NM_001025485.1.
DR   AlphaFoldDB; Q4V909; -.
DR   SMR; Q4V909; -.
DR   STRING; 7955.ENSDARP00000090542; -.
DR   PaxDb; Q4V909; -.
DR   PRIDE; Q4V909; -.
DR   GeneID; 556259; -.
DR   KEGG; dre:556259; -.
DR   CTD; 28952; -.
DR   ZFIN; ZDB-GENE-050913-93; ccdc22.
DR   eggNOG; KOG1937; Eukaryota.
DR   InParanoid; Q4V909; -.
DR   OrthoDB; 985190at2759; -.
DR   PhylomeDB; Q4V909; -.
DR   Reactome; R-DRE-8951664; Neddylation.
DR   PRO; PR:Q4V909; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR   GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR008530; CCDC22.
DR   PANTHER; PTHR15668; PTHR15668; 1.
DR   Pfam; PF05667; DUF812; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Protein transport; Reference proteome; Transport;
KW   Ubl conjugation pathway.
FT   CHAIN           1..639
FT                   /note="Coiled-coil domain-containing protein 22"
FT                   /id="PRO_0000338400"
FT   COILED          331..370
FT                   /evidence="ECO:0000255"
FT   COILED          459..541
FT                   /evidence="ECO:0000255"
FT   COILED          591..638
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   639 AA;  71986 MW;  41DF230E9CC62654 CRC64;
     MEEVDRILIH SLRQAGTDID EDVQSVKQFT SELIVEAVVR CLRVIDPAVG NGLSHSLPPG
     MSARFRLGMS LAQACQDVGF KGEIGYQTFL YSNEPEIRSL FMFLVERLPR ESAEASDQPA
     GKSVLLQRAI AAQIKAQLSV PWLPPTCRLP VHRKTQSSGP CHSFHAQPLS LPCSLKVSSR
     KQPKEVQEYW RNYLLPVTAQ PSQPASVPAS LLENHISELS AAQEWESEWN SQGLLSRLTP
     EEYRSRKKAR LQKRIEEQLR TAAQPRPDTH GATRSTSDLA ELLQSFGGAS TGGDVLTKGT
     RFTHTEKFTF TQEPEKAVQQ MAAAASALPS SQQSEEDLKA QQEAELSALQ QQLQQLSVQM
     EEVGGGIKQL TVSIQQVTDE LQTREVTNAE RENSVKIKRQ TIDLLPDAEN NLLKLQSLVE
     SSSKRVVQLA SQWEKHRVPL IDEHRRLKEL CSNRESESSR KLSEIKDLHD KIRQSAEEAK
     KKESLYKQLL TEFETLSKDV SRSAYTIRIL EIVGNIKKQK EEITKILSDT KDLQKEINGL
     TGKLDRTFAV TDELVFKDAK KDESVRKSYK YLAALHENCT QLIQTIEDTG TIMREIRDLE
     EQIETENGKR TVSNLEKILE DYKAIRQENS ALAAKIREG