ID   CCD22_DROME             Reviewed;         555 AA.
AC   Q9VVB4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Coiled-coil domain-containing protein 22 homolog;
GN   ORFNames=CG9951;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Head;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- SIMILARITY: Belongs to the CCDC22 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE014296; AAF49399.1; -; Genomic_DNA.
DR   EMBL; AY058359; AAL13588.1; -; mRNA.
DR   RefSeq; NP_648929.1; NM_140672.3.
DR   AlphaFoldDB; Q9VVB4; -.
DR   SMR; Q9VVB4; -.
DR   BioGRID; 65187; 24.
DR   IntAct; Q9VVB4; 12.
DR   STRING; 7227.FBpp0075096; -.
DR   PaxDb; Q9VVB4; -.
DR   PRIDE; Q9VVB4; -.
DR   DNASU; 39888; -.
DR   EnsemblMetazoa; FBtr0075337; FBpp0075096; FBgn0036671.
DR   GeneID; 39888; -.
DR   KEGG; dme:Dmel_CG9951; -.
DR   UCSC; CG9951-RA; d. melanogaster.
DR   FlyBase; FBgn0036671; CG9951.
DR   VEuPathDB; VectorBase:FBgn0036671; -.
DR   eggNOG; KOG1937; Eukaryota.
DR   GeneTree; ENSGT00390000003809; -.
DR   HOGENOM; CLU_024231_1_0_1; -.
DR   InParanoid; Q9VVB4; -.
DR   OMA; KFEQHIQ; -.
DR   OrthoDB; 985190at2759; -.
DR   PhylomeDB; Q9VVB4; -.
DR   Reactome; R-DME-8951664; Neddylation.
DR   BioGRID-ORCS; 39888; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 39888; -.
DR   PRO; PR:Q9VVB4; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0036671; Expressed in capitellum (Drosophila) and 23 other tissues.
DR   Genevisible; Q9VVB4; DM.
DR   GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR   GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR008530; CCDC22.
DR   PANTHER; PTHR15668; PTHR15668; 2.
DR   Pfam; PF05667; DUF812; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..555
FT                   /note="Coiled-coil domain-containing protein 22 homolog"
FT                   /id="PRO_0000338405"
FT   COILED          263..406
FT                   /evidence="ECO:0000255"
FT   COILED          500..555
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   555 AA;  63013 MW;  528A5BBCD625AEA1 CRC64;
     MDEVDKIIMH QLHQVDATIE PTDELSDFTP EQVVRAVSGC LAEIRPDLQL PRTLPGGAMA
     QRFGVASSLA QGCKDSGYRG DIGYQTFLYP NAVELRRLLM FLIEQLPRER QGTEDGASKS
     QTLSHRQLLE RKIRKELAQQ LKTPWVPQFA RSVGNRKLLG CSSLGIEFRP NINLNIPSAN
     PEERSKEQQQ YLDQQAPNLF QQTSSTSTDL IASVLHKNEL DRWGQILPDS TLIFVSSEDP
     APPLIPTVKP PASAEKEEEP SPIQELSDQV QELRVQCENL LAERKAHAVA IAALKQRETK
     AREEISRIQP TLKLHERTSL VLADSEENLA KLEALLKSTQ SKRLTLTQQW QDYRKPLLES
     LEKLKTAKEA QEVQGIRNSI EQLEQELLAK TQQHNELNAT LRSASQSLAP RKEYTRRIHE
     FIGNIRKQRA DIYKVLDDTR QLQKQLNVVG AQLQRQFNYT DDLLFQSAKH DLHAKRAYKL
     LAQLHANCNE LVECVSLTGN VTKQIRELEV QIDGEKLKNV LTSLQQITGD IQKFEQHIQE
     LQEQIRAVEQ TNAGS