ID   CCD22_XENTR             Reviewed;         632 AA.
AC   Q28G12; Q6DIG1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Coiled-coil domain-containing protein 22;
GN   Name=ccdc22; ORFNames=tgas103k19.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in regulation of NF-kappa-B signaling. May be
CC       involved in copper-dependent atp7a trafficking between the trans-Golgi
CC       network and vesicles in the cell periphery (By similarity).
CC       {ECO:0000250|UniProtKB:O60826}.
CC   -!- SIMILARITY: Belongs to the CCDC22 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH75581.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CR761632; CAJ82509.1; -; mRNA.
DR   EMBL; BC075581; AAH75581.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_001004994.1; NM_001004994.1.
DR   AlphaFoldDB; Q28G12; -.
DR   SMR; Q28G12; -.
DR   STRING; 8364.ENSXETP00000015634; -.
DR   PaxDb; Q28G12; -.
DR   PRIDE; Q28G12; -.
DR   DNASU; 448468; -.
DR   GeneID; 448468; -.
DR   KEGG; xtr:448468; -.
DR   CTD; 28952; -.
DR   Xenbase; XB-GENE-979496; ccdc22.
DR   eggNOG; KOG1937; Eukaryota.
DR   InParanoid; Q28G12; -.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR   GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR008530; CCDC22.
DR   PANTHER; PTHR15668; PTHR15668; 1.
DR   Pfam; PF05667; DUF812; 1.
PE   2: Evidence at transcript level;
KW   Protein transport; Reference proteome; Transport; Ubl conjugation pathway.
FT   CHAIN           1..632
FT                   /note="Coiled-coil domain-containing protein 22"
FT                   /id="PRO_0000338402"
SQ   SEQUENCE   632 AA;  72586 MW;  77E0427171A477BC CRC64;
     MEEVDRILIH SLRSCGTEVP EDVQSIRQFN TELIVEAVVR CLRVINPSLG ATLSHVLPPG
     MSARFRIGTS LAQACQDLGY PGEVGYQTFL YSSEPDIRAL LIFLAEKLPR DSPEDAHQPA
     GKSALLQREI AATIKRQLSL PWLPSSCRIC ALRRSQNSCR LHRFHAQPLS LATDPTLKSI
     PDERKEYWQC YLPSVTSQLP HLPSVAASLL ERNTSELSAK QEWDAEWKSQ GLASRLSPED
     YRSRKRQRLQ KRIQEQLRQC AQLLAENHLP SSSSQDLTDM LKAFNLDGGS DQKKGSRFTR
     TQRFTYQQDP HTLKEQMQRA AEILPKKDAQ DTDAEQQELS SLQEQIDSIE QEIRGLSESN
     KRLQLTVSQV EGEVNEMRQS CEEKEKIVRV KKRAVELLPD ADNNLVKLQA LVDASSHRMA
     NLVGQWESHQ VRLSEEYREL KRVQQEQEDE SSRWMKDAKD LYEKIRGAAD EAKRKEELYK
     QLLSEYESLP KEVSRAAYTQ RILEIVSNIK KQKEEITKIL SDTKELQKEI NNLTGKVDRT
     FVVTDELVFK DAKKDEPVRK AYKYLAALHE NCSQLIQTIE DTGTILREIR DLEEQIETET
     TKKTLSNLQK ILEDYRAIKQ ENAQLLARIR EA