CCD24_HUMAN
ID CCD24_HUMAN Reviewed; 307 AA.
AC Q8N4L8; Q6RWT2;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Coiled-coil domain-containing protein 24;
GN Name=CCDC24;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Zhou G., Zhong G., Ke R., Li H., Shen C., Lin L., Yang S.;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N4L8; P18825: ADRA2C; NbExp=3; IntAct=EBI-1104933, EBI-12015266;
CC Q8N4L8; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-1104933, EBI-357530;
CC Q8N4L8; Q9BQD7: ANTKMT; NbExp=3; IntAct=EBI-1104933, EBI-713602;
CC Q8N4L8; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-1104933, EBI-396137;
CC Q8N4L8; A8MTA8-2: FAM166B; NbExp=3; IntAct=EBI-1104933, EBI-12160437;
CC Q8N4L8; P49356: FNTB; NbExp=3; IntAct=EBI-1104933, EBI-602349;
CC Q8N4L8; P15976: GATA1; NbExp=3; IntAct=EBI-1104933, EBI-3909284;
CC Q8N4L8; P15976-2: GATA1; NbExp=3; IntAct=EBI-1104933, EBI-9090198;
CC Q8N4L8; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-1104933, EBI-747204;
CC Q8N4L8; Q14525: KRT33B; NbExp=3; IntAct=EBI-1104933, EBI-1049638;
CC Q8N4L8; O76011: KRT34; NbExp=5; IntAct=EBI-1104933, EBI-1047093;
CC Q8N4L8; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-1104933, EBI-11953846;
CC Q8N4L8; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-1104933, EBI-11992140;
CC Q8N4L8; Q8IUB9: KRTAP19-1; NbExp=5; IntAct=EBI-1104933, EBI-12811111;
CC Q8N4L8; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-1104933, EBI-12805508;
CC Q8N4L8; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-1104933, EBI-10241353;
CC Q8N4L8; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-1104933, EBI-12111050;
CC Q8N4L8; Q9P2M1: LRP2BP; NbExp=3; IntAct=EBI-1104933, EBI-18273118;
CC Q8N4L8; P43360: MAGEA6; NbExp=3; IntAct=EBI-1104933, EBI-1045155;
CC Q8N4L8; O14561: NDUFAB1; NbExp=3; IntAct=EBI-1104933, EBI-1246261;
CC Q8N4L8; P17568: NDUFB7; NbExp=3; IntAct=EBI-1104933, EBI-1246238;
CC Q8N4L8; O43482: OIP5; NbExp=5; IntAct=EBI-1104933, EBI-536879;
CC Q8N4L8; Q96EP0-3: RNF31; NbExp=3; IntAct=EBI-1104933, EBI-10225152;
CC Q8N4L8; Q8IYN2: TCEAL8; NbExp=3; IntAct=EBI-1104933, EBI-2116184;
CC Q8N4L8; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-1104933, EBI-5235829;
CC Q8N4L8; Q15654: TRIP6; NbExp=3; IntAct=EBI-1104933, EBI-742327;
CC Q8N4L8; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-1104933, EBI-9090990;
CC Q8N4L8; Q6PF05: TTC23L; NbExp=5; IntAct=EBI-1104933, EBI-8656864;
CC Q8N4L8; Q8N6Y0: USHBP1; NbExp=6; IntAct=EBI-1104933, EBI-739895;
CC Q8N4L8; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-1104933, EBI-11975223;
CC Q8N4L8; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-1104933, EBI-12040603;
CC Q8N4L8; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-1104933, EBI-12030590;
CC Q8N4L8; G4XUV3; NbExp=3; IntAct=EBI-1104933, EBI-10177989;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N4L8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N4L8-2; Sequence=VSP_018148;
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DR EMBL; AY487420; AAR39430.1; -; mRNA.
DR EMBL; AL139220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC033868; AAH33868.1; -; mRNA.
DR CCDS; CCDS507.1; -. [Q8N4L8-1]
DR RefSeq; NP_689712.1; NM_152499.2. [Q8N4L8-1]
DR RefSeq; XP_016855930.1; XM_017000441.1.
DR AlphaFoldDB; Q8N4L8; -.
DR SMR; Q8N4L8; -.
DR BioGRID; 127217; 36.
DR IntAct; Q8N4L8; 36.
DR MINT; Q8N4L8; -.
DR STRING; 9606.ENSP00000361392; -.
DR BioMuta; CCDC24; -.
DR DMDM; 74750991; -.
DR MaxQB; Q8N4L8; -.
DR PaxDb; Q8N4L8; -.
DR PeptideAtlas; Q8N4L8; -.
DR PRIDE; Q8N4L8; -.
DR ProteomicsDB; 71941; -. [Q8N4L8-1]
DR ProteomicsDB; 71942; -. [Q8N4L8-2]
DR Antibodypedia; 68663; 84 antibodies from 13 providers.
DR DNASU; 149473; -.
DR Ensembl; ENST00000372318.8; ENSP00000361392.3; ENSG00000159214.13. [Q8N4L8-1]
DR GeneID; 149473; -.
DR KEGG; hsa:149473; -.
DR MANE-Select; ENST00000372318.8; ENSP00000361392.3; NM_152499.4; NP_689712.1.
DR UCSC; uc001clj.4; human. [Q8N4L8-1]
DR CTD; 149473; -.
DR GeneCards; CCDC24; -.
DR HGNC; HGNC:28688; CCDC24.
DR HPA; ENSG00000159214; Low tissue specificity.
DR neXtProt; NX_Q8N4L8; -.
DR OpenTargets; ENSG00000159214; -.
DR PharmGKB; PA142672182; -.
DR VEuPathDB; HostDB:ENSG00000159214; -.
DR eggNOG; ENOG502S6CH; Eukaryota.
DR GeneTree; ENSGT00390000011926; -.
DR HOGENOM; CLU_993818_0_0_1; -.
DR InParanoid; Q8N4L8; -.
DR OMA; RKAICEG; -.
DR OrthoDB; 1187954at2759; -.
DR PhylomeDB; Q8N4L8; -.
DR TreeFam; TF336952; -.
DR PathwayCommons; Q8N4L8; -.
DR SignaLink; Q8N4L8; -.
DR BioGRID-ORCS; 149473; 14 hits in 1083 CRISPR screens.
DR GenomeRNAi; 149473; -.
DR Pharos; Q8N4L8; Tdark.
DR PRO; PR:Q8N4L8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N4L8; protein.
DR Bgee; ENSG00000159214; Expressed in right uterine tube and 96 other tissues.
DR ExpressionAtlas; Q8N4L8; baseline and differential.
DR Genevisible; Q8N4L8; HS.
DR GO; GO:0001835; P:blastocyst hatching; IEA:Ensembl.
DR InterPro; IPR031367; CCDC24.
DR PANTHER; PTHR28601; PTHR28601; 1.
DR Pfam; PF15669; CCDC24; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..307
FT /note="Coiled-coil domain-containing protein 24"
FT /id="PRO_0000233666"
FT REGION 223..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 168..225
FT /evidence="ECO:0000255"
FT COMPBIAS 223..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 43..78
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_018148"
FT CONFLICT 27
FT /note="I -> V (in Ref. 1; AAR39430)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 307 AA; 34322 MW; 55B2AD791E85B1F4 CRC64;
MLRHSPSLWE LVEEHVPLRE RREVKRILGE AAVDLSLELR AEVAMLRALL QEARSSQAPS
SRPISDPSSL LAPPPLLKDL LRQELRQLLQ GLRHKAICEG RDQAQAWVQY SPRVLHFALE
EPRCDLPEQE IFQMRGGGPS SGHRDLSIIK DQLNVSNIDQ VARHLRGLLE EECHTLEREI
LILQRCLEEE YLRPCHPSEA ALEPTLAELK EQKKAMEQEL QASVGPSCVS PNHRQRPLGS
STQGLRPPLP LCGVAPLQCC LPAPPLEPYL RPRGQSATHR WGRQLQCSPR EGPASTPMSS
AAPQAPA
