ID   CCD25_BOVIN             Reviewed;         208 AA.
AC   Q3SZX8;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Coiled-coil domain-containing protein 25 {ECO:0000305};
GN   Name=CCDC25 {ECO:0000250|UniProtKB:Q86WR0};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transmembrane receptor that senses neutrophil extracellular
CC       traps (NETs) and triggers the ILK-PARVB pathway to enhance cell
CC       motility. NETs are mainly composed of DNA fibers and are released by
CC       neutrophils to bind pathogens during inflammation. Formation of NETs is
CC       also associated with cancer metastasis, NET-DNA acting as a chemotactic
CC       factor to attract cancer cells. Specifically binds NETs on its
CC       extracellular region, in particular the 8-OHdG-enriched DNA present in
CC       NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce
CC       cytoskeleton rearrangement and directional migration of cells.
CC       {ECO:0000250|UniProtKB:Q86WR0}.
CC   -!- SUBUNIT: Interacts (via cytoplasmic region) with ILK.
CC       {ECO:0000250|UniProtKB:Q86WR0}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86WR0};
CC       Single-pass membrane protein {ECO:0000250|UniProtKB:Q86WR0}.
CC       Endomembrane system {ECO:0000250|UniProtKB:Q86WR0}. Note=Localizes to
CC       cytoplasmic membrane in tumor cells. {ECO:0000250|UniProtKB:Q86WR0}.
CC   -!- SIMILARITY: Belongs to the CCDC25 family. {ECO:0000305}.
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DR   EMBL; BC102662; AAI02663.1; -; mRNA.
DR   RefSeq; NP_001030216.1; NM_001035044.1.
DR   AlphaFoldDB; Q3SZX8; -.
DR   SMR; Q3SZX8; -.
DR   STRING; 9913.ENSBTAP00000008601; -.
DR   PaxDb; Q3SZX8; -.
DR   PRIDE; Q3SZX8; -.
DR   GeneID; 507275; -.
DR   KEGG; bta:507275; -.
DR   CTD; 55246; -.
DR   eggNOG; KOG3272; Eukaryota.
DR   HOGENOM; CLU_076656_0_1_1; -.
DR   InParanoid; Q3SZX8; -.
DR   OrthoDB; 1380409at2759; -.
DR   TreeFam; TF300013; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0012505; C:endomembrane system; ISS:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:2000147; P:positive regulation of cell motility; ISS:UniProtKB.
DR   InterPro; IPR039730; Jlp2/Ccd25.
DR   InterPro; IPR008532; NFACT_RNA-bd.
DR   PANTHER; PTHR13049; PTHR13049; 1.
DR   Pfam; PF05670; NFACT-R_1; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell membrane; Coiled coil; DNA-binding; Membrane;
KW   Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..208
FT                   /note="Coiled-coil domain-containing protein 25"
FT                   /id="PRO_0000233403"
FT   TOPO_DOM        1..105
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        106..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..208
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   REGION          21..25
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q86WR0"
FT   REGION          145..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          117..187
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        145..186
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..208
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         23
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86WR0"
FT   MOD_RES         204
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86WR0"
SQ   SEQUENCE   208 AA;  24618 MW;  E7450B6D44B90BAF CRC64;
     MVFYFTSSSV NSSAYTIYMG KDKYENEDLI KYGWPEDIWF HVDKLSSAHV YLRLHKGEKI
     EDIPKEVLMD CAHLVKANSI QGCKMNNVNV VYTPWSNLKK TADMDVGQIG FHRQKDVKIV
     TVEKKVNEIL NRLEKTKMER FPDLEAEKEC RDHEERNEKK AQIQEMKRRE KEEMKKKREM
     DELRSYSSLM KVENMSSNQD GNDSDEFM