ID   CCD25_XENTR             Reviewed;         206 AA.
AC   Q6GLE1;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Coiled-coil domain-containing protein 25 {ECO:0000305};
GN   Name=ccdc25 {ECO:0000250|UniProtKB:Q86WR0};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transmembrane receptor that senses neutrophil extracellular
CC       traps (NETs) and triggers the ILK-PARVB pathway to enhance cell
CC       motility. NETs are mainly composed of DNA fibers and are released by
CC       neutrophils to bind pathogens during inflammation. Specifically binds
CC       NETs on its extracellular region, in particular the 8-OHdG-enriched DNA
CC       present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to
CC       induce cytoskeleton rearrangement and directional migration of cells.
CC       {ECO:0000250|UniProtKB:Q86WR0}.
CC   -!- SUBUNIT: Interacts (via cytoplasmic region) with ILK.
CC       {ECO:0000250|UniProtKB:Q86WR0}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86WR0};
CC       Single-pass membrane protein {ECO:0000250|UniProtKB:Q86WR0}.
CC       Endomembrane system {ECO:0000250|UniProtKB:Q86WR0}. Note=Localizes to
CC       cytoplasmic membrane in tumor cells. {ECO:0000250|UniProtKB:Q86WR0}.
CC   -!- SIMILARITY: Belongs to the CCDC25 family. {ECO:0000305}.
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DR   EMBL; BC074557; AAH74557.1; -; mRNA.
DR   RefSeq; NP_001004803.1; NM_001004803.1.
DR   AlphaFoldDB; Q6GLE1; -.
DR   SMR; Q6GLE1; -.
DR   STRING; 8364.ENSXETP00000034478; -.
DR   DNASU; 448037; -.
DR   GeneID; 448037; -.
DR   KEGG; xtr:448037; -.
DR   CTD; 55246; -.
DR   Xenbase; XB-GENE-5887637; ccdc25.
DR   InParanoid; Q6GLE1; -.
DR   OrthoDB; 1380409at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0012505; C:endomembrane system; ISS:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:2000147; P:positive regulation of cell motility; ISS:UniProtKB.
DR   InterPro; IPR039730; Jlp2/Ccd25.
DR   InterPro; IPR008532; NFACT_RNA-bd.
DR   PANTHER; PTHR13049; PTHR13049; 1.
DR   Pfam; PF05670; NFACT-R_1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; DNA-binding; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..206
FT                   /note="Coiled-coil domain-containing protein 25"
FT                   /id="PRO_0000233408"
FT   TOPO_DOM        1..114
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        115..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        132..206
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   REGION          20..24
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q86WR0"
FT   REGION          139..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          141..185
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        139..184
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   206 AA;  24280 MW;  026C9670D538E36B CRC64;
     MVFYFTSNVI SPPYTMYMGK DKYENEDLIK YGWPEDIWFH VDKLSSAHVY LRLQKDQTIE
     DIPKEVLLDC AQLVKANSIQ GCKMNNINVV YTPWANLKKT ADMDIGQIGF HRQKDVKTMT
     VEKVSKIVNR LEKTKDERFP DLAAEKEARD REERNEKKAQ IQEIKRKEKE EMKKKKEMDE
     LRSYSSLMKS ENMSSNQDGN DSDDFM