CCD27_HUMAN
ID CCD27_HUMAN Reviewed; 656 AA.
AC Q2M243; Q5TBV3; Q96M50;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Coiled-coil domain-containing protein 27;
GN Name=CCDC27;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLU-54 AND THR-267.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLU-54; THR-267 AND
RP MET-353.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q2M243; P43364: MAGEA11; NbExp=3; IntAct=EBI-12314269, EBI-739552;
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DR EMBL; AK057387; BAB71462.1; -; mRNA.
DR EMBL; AL136528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL365330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC112108; AAI12109.1; -; mRNA.
DR EMBL; BC112112; AAI12113.1; -; mRNA.
DR CCDS; CCDS50.1; -.
DR RefSeq; NP_689705.2; NM_152492.2.
DR AlphaFoldDB; Q2M243; -.
DR SMR; Q2M243; -.
DR BioGRID; 127177; 11.
DR IntAct; Q2M243; 7.
DR STRING; 9606.ENSP00000294600; -.
DR iPTMnet; Q2M243; -.
DR PhosphoSitePlus; Q2M243; -.
DR BioMuta; CCDC27; -.
DR DMDM; 94707506; -.
DR MassIVE; Q2M243; -.
DR MaxQB; Q2M243; -.
DR PaxDb; Q2M243; -.
DR PeptideAtlas; Q2M243; -.
DR PRIDE; Q2M243; -.
DR ProteomicsDB; 61346; -.
DR Antibodypedia; 52630; 47 antibodies from 9 providers.
DR DNASU; 148870; -.
DR Ensembl; ENST00000294600.7; ENSP00000294600.2; ENSG00000162592.10.
DR GeneID; 148870; -.
DR KEGG; hsa:148870; -.
DR MANE-Select; ENST00000294600.7; ENSP00000294600.2; NM_152492.3; NP_689705.2.
DR UCSC; uc001akv.3; human.
DR CTD; 148870; -.
DR DisGeNET; 148870; -.
DR GeneCards; CCDC27; -.
DR HGNC; HGNC:26546; CCDC27.
DR HPA; ENSG00000162592; Tissue enriched (testis).
DR neXtProt; NX_Q2M243; -.
DR OpenTargets; ENSG00000162592; -.
DR PharmGKB; PA142672185; -.
DR VEuPathDB; HostDB:ENSG00000162592; -.
DR eggNOG; ENOG502RXSM; Eukaryota.
DR GeneTree; ENSGT00940000154171; -.
DR HOGENOM; CLU_025625_0_0_1; -.
DR InParanoid; Q2M243; -.
DR OMA; MRPGCPQ; -.
DR OrthoDB; 814498at2759; -.
DR PhylomeDB; Q2M243; -.
DR TreeFam; TF335685; -.
DR PathwayCommons; Q2M243; -.
DR SignaLink; Q2M243; -.
DR BioGRID-ORCS; 148870; 22 hits in 1066 CRISPR screens.
DR GenomeRNAi; 148870; -.
DR Pharos; Q2M243; Tdark.
DR PRO; PR:Q2M243; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q2M243; protein.
DR Bgee; ENSG00000162592; Expressed in left testis and 26 other tissues.
DR ExpressionAtlas; Q2M243; baseline and differential.
DR Genevisible; Q2M243; HS.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..656
FT /note="Coiled-coil domain-containing protein 27"
FT /id="PRO_0000234020"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 241..278
FT /evidence="ECO:0000255"
FT COMPBIAS 368..390
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 54
FT /note="Q -> E (in dbSNP:rs10910021)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_026159"
FT VARIANT 267
FT /note="M -> T (in dbSNP:rs1181883)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_026160"
FT VARIANT 353
FT /note="T -> M (in dbSNP:rs10910024)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_026161"
FT VARIANT 390
FT /note="P -> L (in dbSNP:rs11806371)"
FT /id="VAR_056777"
FT CONFLICT 43
FT /note="R -> C (in Ref. 1; BAB71462)"
FT /evidence="ECO:0000305"
FT CONFLICT 380
FT /note="R -> K (in Ref. 1; BAB71462)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 656 AA; 75354 MW; 08F4420F767498F1 CRC64;
MFEAIFPSTP QARLKRDPRE KPGLSSFRST FRQQSSLGLC IPRLMLPKEA SPSQRHSSMS
SSMARALVLL QSMASRDARC PEWKPHQKPR TLSKSVQTIS RYYRKTSEPK DAASLTGFMS
KMELRRVFPT HPDCPQFSTR ATSMSHCGSP TEADLSGEID NSSETWRGTQ DLFLARRGSD
TNVDGYLLPF SKSICEFDYL RKRRKSQTLS PVTSSSVASQ SCLRKRMPWY LSVIHEKDHC
LSELEIQVQK KDEEILLLQE EREALKMQLK CLLKGKGQET SMSPGRREQL SDASLKLGRL
SLLKAFSRHE EELQHWWQMQ EESAAPERGK EPDLGGGEED EGLEGEPDGV EDTGAWGGVS
QMGSVHEEGS EEEEEEEGDR DEDSEERELP EEEEIPRRRA SSLAESFEEE LLAQLEEYEQ
VILDFQFNLE ATRTRYSLAT GVIASLQQQV DFQETQLRKI NTENETLQKE LRERRQQLQA
MTDKFSNLRE DKKHQEMMGL IEKDNQLLRQ QVSELERKLT KRDCVISELD TKVSQLQEQV
ELDQNHLQRW KQLQEDLQSK KEMIQQAEQH TRVALESSQS RLERLRNKII QATFSISGTK
SLANEISDND ILEALQRIIS ERSDYYNQLK QKGVKVPPLQ QSEAFLTSKS KKGTSK
