ID   CCD2_LOTGI              Reviewed;         302 AA.
AC   B3A0Q7;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Coiled-coil domain-containing protein 2;
DE   AltName: Full=Uncharacterized shell protein 9;
DE            Short=LUSP-9;
DE   Flags: Precursor;
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND IDENTIFICATION.
RC   TISSUE=Mantle {ECO:0000269|Ref.1};
RA   Richardson P., Lucas S., Rokhsar D., Wang M., Lindquist E.A.;
RT   "DOE Joint Genome Institute Lottia gigantea EST project.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 56-65 AND 101-117, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Shell;
RX   PubMed=23145877; DOI=10.1111/febs.12062;
RA   Marie B., Jackson D.J., Ramos-Silva P., Zanella-Cleon I., Guichard N.,
RA   Marin F.;
RT   "The shell-forming proteome of Lottia gigantea reveals both deep
RT   conservations and lineage-specific novelties.";
RL   FEBS J. 280:214-232(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23145877}.
CC   -!- TISSUE SPECIFICITY: Component of the acid-insoluble organic matrix of
CC       calcified layers of the shell (at protein level).
CC       {ECO:0000269|PubMed:23145877}.
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DR   EMBL; FC624053; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; FC625182; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; B3A0Q7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Coiled coil; Direct protein sequencing; Glycoprotein; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..302
FT                   /note="Coiled-coil domain-containing protein 2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000415244"
FT   REGION          221..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          198..234
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        242
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   302 AA;  31608 MW;  AE37594E3C27B2E9 CRC64;
     MKNFGLLVVC LSLATLVIPS DGVHIDGDAA PFFVVSQIQH TAGNPAVVGS SYTGRTAVAP
     PLNMRTNVAV PSTLGINSVN IGTNLPTFYQ PTPQPVRSFK NTIDPSLLYS LMAGGLRGDG
     FLNQLNTIEF SSPAEVIDAV ENAVENRADA IKDVIETVSG AVQNGDDEVE GIYDVFAEDD
     SENPVENLDD SDGVYDVFAD AMEKKAEALE NAAEAAAEYI SDQSEEVDDL SEEVLDDDSD
     ENDSTSSESE VEDSDVDLEV DVGIDLGGDL DLGGGVDLGG GMGMGGALNM NGGLDMGGRY
     GR