CCD30_MOUSE
ID CCD30_MOUSE Reviewed; 654 AA.
AC Q8BVF4; Q14CD0; Q3TR07; Q9D9N6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Coiled-coil domain-containing protein 30;
DE AltName: Full=Prefoldin subunit 6-like protein;
GN Name=Ccdc30; Synonyms=Pfdn6l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BVF4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BVF4-2; Sequence=VSP_033800;
CC Name=3;
CC IsoId=Q8BVF4-3; Sequence=VSP_033798, VSP_033799, VSP_033801,
CC VSP_033802;
CC -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC {ECO:0000305}.
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DR EMBL; AK006668; BAB24696.1; -; mRNA.
DR EMBL; AK078362; BAC37237.1; -; mRNA.
DR EMBL; AK163185; BAE37224.1; -; mRNA.
DR EMBL; BX470216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC114436; AAI14437.1; -; mRNA.
DR CCDS; CCDS38861.1; -. [Q8BVF4-1]
DR CCDS; CCDS89822.1; -. [Q8BVF4-2]
DR RefSeq; NP_001257364.1; NM_001270435.1. [Q8BVF4-2]
DR RefSeq; NP_083562.1; NM_029286.2. [Q8BVF4-1]
DR AlphaFoldDB; Q8BVF4; -.
DR SMR; Q8BVF4; -.
DR STRING; 10090.ENSMUSP00000070621; -.
DR iPTMnet; Q8BVF4; -.
DR PhosphoSitePlus; Q8BVF4; -.
DR MaxQB; Q8BVF4; -.
DR PaxDb; Q8BVF4; -.
DR PRIDE; Q8BVF4; -.
DR ProteomicsDB; 281305; -. [Q8BVF4-1]
DR ProteomicsDB; 281306; -. [Q8BVF4-2]
DR ProteomicsDB; 281307; -. [Q8BVF4-3]
DR Antibodypedia; 52243; 67 antibodies from 11 providers.
DR Ensembl; ENSMUST00000044781; ENSMUSP00000047534; ENSMUSG00000028637. [Q8BVF4-3]
DR Ensembl; ENSMUST00000238293; ENSMUSP00000158680; ENSMUSG00000028637. [Q8BVF4-2]
DR Ensembl; ENSMUST00000238759; ENSMUSP00000158825; ENSMUSG00000028637. [Q8BVF4-1]
DR GeneID; 73332; -.
DR KEGG; mmu:73332; -.
DR UCSC; uc008umc.2; mouse. [Q8BVF4-1]
DR UCSC; uc008umd.2; mouse. [Q8BVF4-2]
DR UCSC; uc008ume.1; mouse. [Q8BVF4-3]
DR CTD; 728621; -.
DR MGI; MGI:1920582; Ccdc30.
DR VEuPathDB; HostDB:ENSMUSG00000028637; -.
DR eggNOG; ENOG502QWNQ; Eukaryota.
DR GeneTree; ENSGT00390000007816; -.
DR HOGENOM; CLU_035106_0_0_1; -.
DR InParanoid; Q8BVF4; -.
DR OMA; CTLRDEM; -.
DR OrthoDB; 185685at2759; -.
DR PhylomeDB; Q8BVF4; -.
DR TreeFam; TF333239; -.
DR BioGRID-ORCS; 73332; 1 hit in 68 CRISPR screens.
DR ChiTaRS; Ccdc30; mouse.
DR PRO; PR:Q8BVF4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BVF4; protein.
DR Bgee; ENSMUSG00000028637; Expressed in spermatid and 174 other tissues.
DR ExpressionAtlas; Q8BVF4; baseline and differential.
DR Genevisible; Q8BVF4; MM.
DR InterPro; IPR031476; DUF4686.
DR Pfam; PF15742; DUF4686; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..654
FT /note="Coiled-coil domain-containing protein 30"
FT /id="PRO_0000336046"
FT REGION 38..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 97..244
FT /evidence="ECO:0000255"
FT COILED 276..559
FT /evidence="ECO:0000255"
FT COMPBIAS 45..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..67
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033798"
FT VAR_SEQ 68..168
FT /note="QDCLLRDVECIAQKLEASLEEIHRGAREPREEREQRTLGDALENARLEIEKL
FT KDNLMKLKESGTTDLQRAREHNQRLDEEILALRNRVRSLDSEKKVLGEM -> MTSENA
FT CEDLVSKGPLLEVEAVSPSEDRQALCSELGESKQEETPDESVKAATFPRERQESQQMRG
FT HEQPLAVEPKEVGRLEEEASLQSQSCGGSSDDSSTK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033799"
FT VAR_SEQ 164..168
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033800"
FT VAR_SEQ 351..376
FT /note="ILLDQDINELQTQVRALQDKEEQQEA -> GLGFAPQHCTNTAIFPGPPLFL
FT SESC (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033801"
FT VAR_SEQ 377..654
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033802"
FT CONFLICT 66
FT /note="A -> V (in Ref. 3; AAI14437)"
FT /evidence="ECO:0000305"
FT CONFLICT 412
FT /note="N -> S (in Ref. 3; AAI14437)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 654 AA; 76048 MW; 06279678033AC5E9 CRC64;
MCQEGLFRLA LSSPRKQTAC SLGERRTLAE ALGLVDSTLE SRRDPNSSLQ KEFPQHQDED
QSRAAAPQDC LLRDVECIAQ KLEASLEEIH RGAREPREER EQRTLGDALE NARLEIEKLK
DNLMKLKESG TTDLQRAREH NQRLDEEILA LRNRVRSLDS EKKVLGEMYL TSGEKTSCQH
QGELRELRQN LRRLQILCNS AEKELRYERG RSLDLKQHNS LLQEENIKIK IELKQAQEKL
LDNARLHSSL TAEWKHCQQK VKELELEGLR QTQSLKSQQG LQEKLAREKS KAAEAQEKIL
DLQQKLDHGR QVCLSDVCIL RKKQLEEEIK EAKSIEARLQ QQCQEEQQRR ILLDQDINEL
QTQVRALQDK EEQQEAVNSQ QQEALRKQLE RERRKCEEYV KSNQELSEKL SNLQQEKEAL
WQEHGRFLEQ LGDHVRNYKD KHHCHKAKLQ KVKDRLTHEL EIRNKRIKEL EDETGKLQQK
IEMEKVFQGQ IMAQNDILLL EKRKLLEQVT DQEELICSSK CTISAFQSKA SLLDKENQQL
QENCLRLMQQ IGLLEQIIRS IQIRREEETV ITDNAAFEIL KKILPLQNSS FSGTGFVLSA
ENLQETELHK WEGAAAIPKS PEPLSRSQDS ESGYINVTSL KETHNTQGDQ KPEL
