ID   CCD33_ARATH             Reviewed;         361 AA.
AC   Q9SN11;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Cyclin-D3-3;
DE   AltName: Full=G1/S-specific cyclin-D3-3;
DE            Short=CycD3;3;
GN   Name=CYCD3-3; OrderedLocusNames=At3g50070; ORFNames=F3A4.150;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15208425; DOI=10.1104/pp.104.040436;
RA   Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W.,
RA   Ma H.;
RT   "Genome-wide analysis of the cyclin family in Arabidopsis and comparative
RT   phylogenetic analysis of plant cyclin-like proteins.";
RL   Plant Physiol. 135:1084-1099(2004).
RN   [6]
RP   INDUCTION BY ERF114.
RX   PubMed=23616605; DOI=10.1104/pp.113.214049;
RA   Mehrnia M., Balazadeh S., Zanor M.I., Mueller-Roeber B.;
RT   "EBE, an AP2/ERF transcription factor highly expressed in proliferating
RT   cells, affects shoot architecture in Arabidopsis.";
RL   Plant Physiol. 162:842-857(2013).
RN   [7]
RP   FUNCTION.
RC   STRAIN=cv. Columbia;
RX   PubMed=24687979; DOI=10.1093/jxb/eru139;
RA   Yang K., Wang H., Xue S., Qu X., Zou J., Le J.;
RT   "Requirement for A-type cyclin-dependent kinase and cyclins for the
RT   terminal division in the stomatal lineage of Arabidopsis.";
RL   J. Exp. Bot. 65:2449-2461(2014).
CC   -!- FUNCTION: Promotes divisions in the guard cells (GCs) after the guard
CC       mother cells (GMC) symmetric division. {ECO:0000269|PubMed:24687979}.
CC   -!- INDUCTION: Up-regulated by the transcription factor ERF114.
CC       {ECO:0000269|PubMed:23616605}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin D subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL132978; CAB62115.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE78623.1; -; Genomic_DNA.
DR   EMBL; AY052665; AAK96569.1; -; mRNA.
DR   EMBL; AY063729; AAL36079.1; -; mRNA.
DR   EMBL; AY087498; AAM65041.1; -; mRNA.
DR   PIR; T45860; T45860.
DR   RefSeq; NP_190576.1; NM_114867.3.
DR   AlphaFoldDB; Q9SN11; -.
DR   SMR; Q9SN11; -.
DR   BioGRID; 9487; 18.
DR   IntAct; Q9SN11; 10.
DR   STRING; 3702.AT3G50070.1; -.
DR   PaxDb; Q9SN11; -.
DR   PRIDE; Q9SN11; -.
DR   EnsemblPlants; AT3G50070.1; AT3G50070.1; AT3G50070.
DR   GeneID; 824169; -.
DR   Gramene; AT3G50070.1; AT3G50070.1; AT3G50070.
DR   KEGG; ath:AT3G50070; -.
DR   Araport; AT3G50070; -.
DR   TAIR; locus:2083128; AT3G50070.
DR   eggNOG; KOG0656; Eukaryota.
DR   HOGENOM; CLU_048040_0_0_1; -.
DR   InParanoid; Q9SN11; -.
DR   OMA; EEQVNQC; -.
DR   OrthoDB; 1234739at2759; -.
DR   PhylomeDB; Q9SN11; -.
DR   PRO; PR:Q9SN11; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9SN11; baseline and differential.
DR   Genevisible; Q9SN11; AT.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0010444; P:guard mother cell differentiation; IMP:UniProtKB.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0048316; P:seed development; IGI:TAIR.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR004367; Cyclin_C-dom.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10177; PTHR10177; 1.
DR   Pfam; PF02984; Cyclin_C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SMART; SM01332; Cyclin_C; 1.
DR   SUPFAM; SSF47954; SSF47954; 1.
DR   PROSITE; PS00292; CYCLINS; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cyclin; Reference proteome.
FT   CHAIN           1..361
FT                   /note="Cyclin-D3-3"
FT                   /id="PRO_0000287026"
SQ   SEQUENCE   361 AA;  41738 MW;  DBBE9329A33B9D02 CRC64;
     MALEEEEESQ NAPFCVLDGL FCEEESEFHE QVDLCDESVE KFPFLNLGLS DHDMLWDDDE
     LSTLISKQEP CLYDEILDDE FLVLCREKAL DWIFKVKSHY GFNSLTALLA VNYFDRFITS
     RKFQTDKPWM SQLTALACLS LAAKVEEIRV PFLLDFQVEE ARYVFEAKTI QRMELLVLST
     LDWRMHPVTP ISFFDHIIRR YSFKSHHQLE FLSRCESLLL SIIPDSRFLS FSPSVLATAI
     MVSVIRDLKM CDEAVYQSQL MTLLKVDSEK VNKCYELVLD HSPSKKRMMN WMQQPASPIG
     VFDASFSSDS SNESWVVSAS ASVSSSPSSE PLLKRRRVQE QQMRLSSINR MFFDVLSSSP
     R