CCD33_HUMAN
ID CCD33_HUMAN Reviewed; 958 AA.
AC Q8N5R6; A8K3U4; A8MPQ6; A8MV61; A8MVU9; B3KQ49; Q8TAX6; Q9H5Q6;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Coiled-coil domain-containing protein 33;
DE AltName: Full=Cancer/testis antigen 61;
DE Short=CT61;
GN Name=CCDC33;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6), AND VARIANT
RP ASN-683.
RC TISSUE=Lung, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 324-958 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N5R6; P53673: CRYBA4; NbExp=3; IntAct=EBI-740841, EBI-7519711;
CC Q8N5R6; P50402: EMD; NbExp=3; IntAct=EBI-740841, EBI-489887;
CC Q8N5R6; P28799: GRN; NbExp=3; IntAct=EBI-740841, EBI-747754;
CC Q8N5R6; Q96ED9: HOOK2; NbExp=2; IntAct=EBI-740841, EBI-743290;
CC Q8N5R6; P40692: MLH1; NbExp=4; IntAct=EBI-740841, EBI-744248;
CC Q8N5R6; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-740841, EBI-1567797;
CC Q8N5R6; O75771: RAD51D; NbExp=3; IntAct=EBI-740841, EBI-1055693;
CC Q8N5R6; P84022: SMAD3; NbExp=4; IntAct=EBI-740841, EBI-347161;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q8N5R6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N5R6-2; Sequence=VSP_028757, VSP_028758;
CC Name=4;
CC IsoId=Q8N5R6-4; Sequence=VSP_028755, VSP_028756, VSP_028759;
CC Name=5;
CC IsoId=Q8N5R6-5; Sequence=VSP_028755, VSP_028756, VSP_028757,
CC VSP_028759;
CC Name=6;
CC IsoId=Q8N5R6-6; Sequence=VSP_040258, VSP_040259;
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DR EMBL; AK057417; BAG51911.1; -; mRNA.
DR EMBL; AK026821; BAB15564.1; -; mRNA.
DR EMBL; AK290709; BAF83398.1; -; mRNA.
DR EMBL; AC023300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031684; AAH31684.1; -; mRNA.
DR CCDS; CCDS42058.1; -. [Q8N5R6-6]
DR CCDS; CCDS42059.1; -. [Q8N5R6-5]
DR CCDS; CCDS73753.1; -. [Q8N5R6-4]
DR RefSeq; NP_001274110.1; NM_001287181.1. [Q8N5R6-4]
DR RefSeq; NP_079331.3; NM_025055.4. [Q8N5R6-6]
DR RefSeq; NP_877592.2; NM_182791.3. [Q8N5R6-5]
DR AlphaFoldDB; Q8N5R6; -.
DR SMR; Q8N5R6; -.
DR BioGRID; 123126; 190.
DR IntAct; Q8N5R6; 61.
DR MINT; Q8N5R6; -.
DR STRING; 9606.ENSP00000381795; -.
DR iPTMnet; Q8N5R6; -.
DR PhosphoSitePlus; Q8N5R6; -.
DR BioMuta; CCDC33; -.
DR DMDM; 205646145; -.
DR EPD; Q8N5R6; -.
DR MassIVE; Q8N5R6; -.
DR PaxDb; Q8N5R6; -.
DR PeptideAtlas; Q8N5R6; -.
DR PRIDE; Q8N5R6; -.
DR ProteomicsDB; 72082; -. [Q8N5R6-1]
DR ProteomicsDB; 72083; -. [Q8N5R6-2]
DR ProteomicsDB; 72084; -. [Q8N5R6-4]
DR ProteomicsDB; 72085; -. [Q8N5R6-5]
DR ProteomicsDB; 72086; -. [Q8N5R6-6]
DR Antibodypedia; 52555; 51 antibodies from 14 providers.
DR DNASU; 80125; -.
DR Ensembl; ENST00000268082.4; ENSP00000268082.4; ENSG00000140481.15. [Q8N5R6-5]
DR Ensembl; ENST00000321374.9; ENSP00000325661.5; ENSG00000140481.15. [Q8N5R6-4]
DR Ensembl; ENST00000398814.8; ENSP00000381795.3; ENSG00000140481.15. [Q8N5R6-6]
DR Ensembl; ENST00000558821.5; ENSP00000452817.1; ENSG00000140481.15. [Q8N5R6-4]
DR Ensembl; ENST00000672175.1; ENSP00000500783.1; ENSG00000288407.1. [Q8N5R6-6]
DR Ensembl; ENST00000672263.1; ENSP00000500591.1; ENSG00000288407.1. [Q8N5R6-4]
DR Ensembl; ENST00000673214.1; ENSP00000500272.1; ENSG00000288407.1. [Q8N5R6-5]
DR Ensembl; ENST00000673517.1; ENSP00000500223.1; ENSG00000288407.1. [Q8N5R6-4]
DR GeneID; 80125; -.
DR KEGG; hsa:80125; -.
DR MANE-Select; ENST00000398814.8; ENSP00000381795.3; NM_025055.5; NP_079331.3. [Q8N5R6-6]
DR UCSC; uc002axo.4; human. [Q8N5R6-1]
DR CTD; 80125; -.
DR DisGeNET; 80125; -.
DR GeneCards; CCDC33; -.
DR HGNC; HGNC:26552; CCDC33.
DR HPA; ENSG00000140481; Group enriched (fallopian tube, testis).
DR MIM; 618525; gene.
DR neXtProt; NX_Q8N5R6; -.
DR OpenTargets; ENSG00000140481; -.
DR PharmGKB; PA142672188; -.
DR VEuPathDB; HostDB:ENSG00000140481; -.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00390000017366; -.
DR HOGENOM; CLU_067728_0_0_1; -.
DR InParanoid; Q8N5R6; -.
DR OMA; RDTEMNN; -.
DR OrthoDB; 1379192at2759; -.
DR PhylomeDB; Q8N5R6; -.
DR TreeFam; TF328975; -.
DR PathwayCommons; Q8N5R6; -.
DR SignaLink; Q8N5R6; -.
DR BioGRID-ORCS; 80125; 15 hits in 1068 CRISPR screens.
DR ChiTaRS; CCDC33; human.
DR GenomeRNAi; 80125; -.
DR Pharos; Q8N5R6; Tdark.
DR PRO; PR:Q8N5R6; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q8N5R6; protein.
DR Bgee; ENSG00000140481; Expressed in right uterine tube and 75 other tissues.
DR ExpressionAtlas; Q8N5R6; baseline and differential.
DR Genevisible; Q8N5R6; HS.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039889; CCD33.
DR PANTHER; PTHR21623; PTHR21623; 1.
DR Pfam; PF00168; C2; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..958
FT /note="Coiled-coil domain-containing protein 33"
FT /id="PRO_0000307643"
FT DOMAIN 214..353
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 602..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 632..774
FT /evidence="ECO:0000255"
FT COILED 859..899
FT /evidence="ECO:0000255"
FT COMPBIAS 910..924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..610
FT /note="Missing (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028755"
FT VAR_SEQ 1..203
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_040258"
FT VAR_SEQ 204..214
FT /note="PPRAGQPELMS -> MGLKNKKNTED (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_040259"
FT VAR_SEQ 611..633
FT /note="DLSTSTPREAEEEPLVPEMSHDT -> MGEPGPPSPPAPKAAPGLIDSFS
FT (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028756"
FT VAR_SEQ 849
FT /note="P -> PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ (in isoform
FT 2 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028757"
FT VAR_SEQ 917..958
FT /note="SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT -> PYSLPP
FT APGASIFGKPRATVDPGGWREEAFQSRGQGDGPLPDPEKKQGHQRPALLGNTREACPFH
FT LPQNIYHV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028758"
FT VAR_SEQ 917..958
FT /note="SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT -> VSDPPG
FT VAPRGSGGGAGSHRTPKVTGP (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028759"
FT VARIANT 635
FT /note="M -> V (in dbSNP:rs2277603)"
FT /id="VAR_045602"
FT VARIANT 640
FT /note="R -> L (in dbSNP:rs2277604)"
FT /id="VAR_045603"
FT VARIANT 683
FT /note="S -> N (in dbSNP:rs1564782)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_036625"
FT CONFLICT 237
FT /note="Missing (in Ref. 1; BAG51911)"
FT /evidence="ECO:0000305"
FT CONFLICT 531
FT /note="K -> E (in Ref. 1; BAG51911)"
FT /evidence="ECO:0000305"
FT CONFLICT 775
FT /note="L -> P (in Ref. 1; BAF83398)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 958 AA; 107216 MW; 1F8A9284396424CA CRC64;
MAFRGPEPWV SASLLRQRLK AEEKTLDLEF EVLSVGFNEA GRYALRLSAE NPLQVGSGAG
VQLQVNDGDP FPACSAITDV IEQQEPGQSL TLTRSKFIFT LPKGFCKNDG QHDAQLHVEA
LRLDEPLGRA AQRVGEAIFP IYPRPDQPRM NPKAQDHEDL YRYCGNLALL RASTDPTARH
CGSLAYSVAF HVHRGPQPPV SDSPPRAGQP ELMSPEEPLI ASQSTEPEIG HLSPSKKETI
MVTLHGATNL PACKDGSEPW PYVVVKSTSE EKNNQSSKAV TSVTSEPTRA PIWGDTVNVE
IQAEDAGQED VILKVVDNRK KQELLSYKIP IKYLRVFHPY HFELVKPTES GKADEATAKT
QLYATVVRKS SFIPRYIGCN HMALEIFLRG VNEPLANNPN PIVVIARVVP NYKEFKVSQA
NRDLASVGLP ITPLSFPIPS MMNFDVPRVS QNGCPQLSKP GGPPEQPLWN QSFLFQGRDG
ATSFSEDTAL VLEYYSSTSM KGSQPWTLNQ PLGISVLPLK SRLYQKMLTG KGLDGLHVER
LPIMDTSLKT INDEAPTVAL SFQLLSSERP ENFLTPNNSK ALPTLDPKIL DKKLRTIQES
WSKDTVSSTM DLSTSTPREA EEEPLVPEMS HDTEMNNYRR AMQKMAEDIL SLRRQASILE
GENRILRSRL AQQEEEEGQG KASEAQNTVS MKQKLLLSEL DMKKLRDRVQ HLQNELIRKN
DREKELLLLY QAQQPQAALL KQYQGKLQKM KALEETVRHQ EKVIEKMERV LEDRLQDRSK
PPPLNRQQGK PYTGFPMLSA SGLPLGSMGE NLPVELYSVL LAENAKLRTE LDKNRHQQAP
IILQQQALPD LLSGTSDKFN LLAKLEHAQS RILSLESQLE DSARRWGREK QDLATRLQEQ
EKGFRHPSNS IIIEQPSALT HSMDLKQPSE LEPLLPSSDS KLNKPLSPQK ETANSQQT
