CCD33_MOUSE
ID CCD33_MOUSE Reviewed; 985 AA.
AC Q3ULW6; Q14B78; Q3TLL8; Q76MG4; Q9D4Z2;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Coiled-coil domain-containing protein 33;
DE AltName: Full=Speriolin-binding factor;
GN Name=Ccdc33;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC STRAIN=BALB/cJ; TISSUE=Testis;
RA Goto M., Eddy E.M.;
RT "Testis-specific leucine-zipper protein TZIP1 associates with speriolin.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
RC STRAIN=C57BL/6J; TISSUE=Mammary gland, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q3ULW6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3ULW6-2; Sequence=VSP_028762, VSP_028763;
CC Name=3;
CC IsoId=Q3ULW6-3; Sequence=VSP_028760, VSP_028761, VSP_028765,
CC VSP_028767, VSP_028769;
CC Name=4;
CC IsoId=Q3ULW6-4; Sequence=VSP_028760, VSP_028761, VSP_028765,
CC VSP_028767, VSP_028768, VSP_028769;
CC Name=5;
CC IsoId=Q3ULW6-5; Sequence=VSP_028760, VSP_028761, VSP_028764,
CC VSP_028766;
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DR EMBL; AB048860; BAD08245.1; -; mRNA.
DR EMBL; AK015980; BAB30064.1; -; mRNA.
DR EMBL; AK145264; BAE26332.1; -; mRNA.
DR EMBL; AK166434; BAE38774.1; -; mRNA.
DR EMBL; BC116291; AAI16292.1; -; mRNA.
DR EMBL; BC116292; AAI16293.1; -; mRNA.
DR CCDS; CCDS40654.1; -. [Q3ULW6-3]
DR CCDS; CCDS52811.1; -. [Q3ULW6-1]
DR CCDS; CCDS81006.1; -. [Q3ULW6-4]
DR RefSeq; NP_001298014.1; NM_001311085.1.
DR RefSeq; NP_083488.1; NM_029212.3.
DR AlphaFoldDB; Q3ULW6; -.
DR SMR; Q3ULW6; -.
DR STRING; 10090.ENSMUSP00000096279; -.
DR iPTMnet; Q3ULW6; -.
DR PhosphoSitePlus; Q3ULW6; -.
DR PaxDb; Q3ULW6; -.
DR PRIDE; Q3ULW6; -.
DR ProteomicsDB; 283724; -. [Q3ULW6-1]
DR ProteomicsDB; 283725; -. [Q3ULW6-2]
DR ProteomicsDB; 283726; -. [Q3ULW6-3]
DR ProteomicsDB; 283727; -. [Q3ULW6-4]
DR ProteomicsDB; 283728; -. [Q3ULW6-5]
DR Antibodypedia; 52555; 51 antibodies from 14 providers.
DR Ensembl; ENSMUST00000098681; ENSMUSP00000096278; ENSMUSG00000037716. [Q3ULW6-2]
DR GeneID; 382077; -.
DR KEGG; mmu:382077; -.
DR UCSC; uc009pwg.1; mouse. [Q3ULW6-5]
DR UCSC; uc009pwh.1; mouse. [Q3ULW6-2]
DR CTD; 80125; -.
DR MGI; MGI:1922464; Ccdc33.
DR VEuPathDB; HostDB:ENSMUSG00000037716; -.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00390000017366; -.
DR HOGENOM; CLU_087317_0_0_1; -.
DR InParanoid; Q3ULW6; -.
DR OrthoDB; 1379192at2759; -.
DR PhylomeDB; Q3ULW6; -.
DR BioGRID-ORCS; 382077; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q3ULW6; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q3ULW6; protein.
DR Bgee; ENSMUSG00000037716; Expressed in spermatid and 35 other tissues.
DR ExpressionAtlas; Q3ULW6; baseline and differential.
DR GO; GO:0005777; C:peroxisome; IDA:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; NAS:UniProtKB.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039889; CCD33.
DR PANTHER; PTHR21623; PTHR21623; 1.
DR Pfam; PF00168; C2; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..985
FT /note="Coiled-coil domain-containing protein 33"
FT /id="PRO_0000307644"
FT DOMAIN 263..398
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 228..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 599..745
FT /evidence="ECO:0000255"
FT COILED 885..928
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..245
FT /note="Missing (in isoform 3, isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_028760"
FT VAR_SEQ 246..252
FT /note="PWQHPAQ -> MGRQKTK (in isoform 3, isoform 4 and
FT isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_028761"
FT VAR_SEQ 253..278
FT /note="VPEEPQGRLDTSQDPYPAANYLAPCN -> AELLKRETLNWKSPVTGFSQPL
FT LPHL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028762"
FT VAR_SEQ 279..985
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028763"
FT VAR_SEQ 352..397
FT /note="DLILKVMDNKRKKELVSYDIPIKYLRIFHPYQFKLEKVFLRGVNEP -> GE
FT AGGWAPVCGRCKWLEPHLPWKAKAVSLSTAGGQLNTSLGSDKSI (in isoform
FT 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028764"
FT VAR_SEQ 388
FT /note="K -> KSEKKDEAAAKTCLYATVVRKGSLLPRYVGCDHTALE (in
FT isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_028765"
FT VAR_SEQ 398..985
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028766"
FT VAR_SEQ 547
FT /note="M -> IDTNLKTINGEAPSVNLSFQLLSSE (in isoform 3 and
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_028767"
FT VAR_SEQ 653
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028768"
FT VAR_SEQ 809..877
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_028769"
FT CONFLICT 364
FT /note="K -> R (in Ref. 3; AAI16293)"
FT /evidence="ECO:0000305"
FT CONFLICT 383
FT /note="Q -> H (in Ref. 2; BAE26332)"
FT /evidence="ECO:0000305"
FT CONFLICT 465
FT /note="G -> R (in Ref. 2; BAE26332)"
FT /evidence="ECO:0000305"
FT CONFLICT 588
FT /note="A -> T (in Ref. 1; BAD08245 and 3; AAI16293/
FT AAI16292)"
FT /evidence="ECO:0000305"
FT CONFLICT 591
FT /note="V -> M (in Ref. 1; BAD08245 and 3; AAI16293/
FT AAI16292)"
FT /evidence="ECO:0000305"
FT CONFLICT 767
FT /note="M -> V (in Ref. 1; BAD08245 and 3; AAI16293/
FT AAI16292)"
FT /evidence="ECO:0000305"
FT CONFLICT 952
FT /note="P -> R (in Ref. 1; BAD08245 and 3; AAI16293/
FT AAI16292)"
FT /evidence="ECO:0000305"
FT CONFLICT 960
FT /note="P -> T (in Ref. 1; BAD08245 and 3; AAI16293/
FT AAI16292)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 985 AA; 110198 MW; 35D1C0827AD3C705 CRC64;
MAFRGPDPYL PASLLSQRLK AGEKTLDLEF EILSVGFNEE GRYALRLSAE NPLQAGSSAG
VQLQVNDGDP LPACSAVTEV IEQQDPGQSL TFTRNKFIFT LPKGFCKNDG QSDAHLRVEA
LRLDGSSGQE AQRVGEAIFP IYPRPDEPRM NLTAQDHEDL YRYCGNLALL RASEDPTARH
CGGLAYSVAF HVHRDPRSSV SDCQLEPSQP ELQTSREALS DKIEESYMSP FSTDSDQEGL
SWEAGPWQHP AQVPEEPQGR LDTSQDPYPA ANYLAPCNKE TITVTLYGAT NLPAGKDGSE
PWPYVVVKTT SEKANKHSPQ AMTSVTSEPT RAPVWGDTVN VEIQAEDTGR EDLILKVMDN
KRKKELVSYD IPIKYLRIFH PYQFKLEKVF LRGVNEPLVN SLKPMVVIAR VVPNYTEFKA
RQARRDPASV GLPLTQVSFP ISSPMNFDVP RINQNGYPQL SKPGGPPEQP LWNQSFLFQA
RDGATSFSEN TALVLEYYPS ASMQSSEPWA LNQPLGVSVL PLKSRLYHKM LTGKHLQGLQ
VERLPIMRPE NFLTPNNSKA LPTINPKILD ENLGAIRESW SMSSLDSAQE VEELQPRDVE
MNNYRRAMQK MAEDILALKK QANILEEENG MLRSHLSQQS IEEQSRAEEE NLAVSMKQKL
LLNELDMKRL RDRVQHLQNE LIRKNDREKE LLLLYQAQQP QAAQLRRYQD KLQKMKALED
TVRHQEKVIE KMEQILEERL CERKEPIPSN RPQGKPIMAS GIPLGPMGET LAVDLYSMLL
AENTRLRTEL EKNRQQSAPI ILQQQALPVD PRELGAGGDL AERLQDTNGP GHPKSTETLP
AQVGVPGGYS TAQAAPGAPA VHKPKINIWS SGGMRTQDFL GGTSDKFNLL AKLEQAQSRI
LSLENQLEES ARHWAREKQN LAIRLQEQQH GFGQPPNSII IDQPNAGASK NPQQLSKLEP
SLPSSDKKLN RPSDSQIEIS NNQKT
