CCD38_HUMAN
ID CCD38_HUMAN Reviewed; 563 AA.
AC Q502W7; Q8N835;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Coiled-coil domain-containing protein 38;
GN Name=CCDC38;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=25074808; DOI=10.1242/jcs.157008;
RA Firat-Karalar E.N., Sante J., Elliott S., Stearns T.;
RT "Proteomic analysis of mammalian sperm cells identifies new components of
RT the centrosome.";
RL J. Cell Sci. 127:4128-4133(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:25074808}.
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DR EMBL; AK097408; BAC05038.1; -; mRNA.
DR EMBL; BC095479; AAH95479.1; -; mRNA.
DR CCDS; CCDS9056.1; -.
DR RefSeq; NP_872302.2; NM_182496.2.
DR RefSeq; XP_011536185.1; XM_011537883.2.
DR AlphaFoldDB; Q502W7; -.
DR SMR; Q502W7; -.
DR BioGRID; 125701; 3.
DR IntAct; Q502W7; 2.
DR STRING; 9606.ENSP00000345470; -.
DR iPTMnet; Q502W7; -.
DR PhosphoSitePlus; Q502W7; -.
DR BioMuta; CCDC38; -.
DR DMDM; 74740178; -.
DR EPD; Q502W7; -.
DR jPOST; Q502W7; -.
DR MassIVE; Q502W7; -.
DR PaxDb; Q502W7; -.
DR PeptideAtlas; Q502W7; -.
DR PRIDE; Q502W7; -.
DR Antibodypedia; 49794; 112 antibodies from 15 providers.
DR DNASU; 120935; -.
DR Ensembl; ENST00000344280.8; ENSP00000345470.3; ENSG00000165972.13.
DR GeneID; 120935; -.
DR KEGG; hsa:120935; -.
DR MANE-Select; ENST00000344280.8; ENSP00000345470.3; NM_182496.3; NP_872302.2.
DR UCSC; uc001tek.3; human.
DR CTD; 120935; -.
DR DisGeNET; 120935; -.
DR GeneCards; CCDC38; -.
DR HGNC; HGNC:26843; CCDC38.
DR HPA; ENSG00000165972; Tissue enriched (testis).
DR neXtProt; NX_Q502W7; -.
DR OpenTargets; ENSG00000165972; -.
DR PharmGKB; PA142672193; -.
DR VEuPathDB; HostDB:ENSG00000165972; -.
DR eggNOG; ENOG502QSDI; Eukaryota.
DR GeneTree; ENSGT00940000153110; -.
DR HOGENOM; CLU_026271_1_0_1; -.
DR InParanoid; Q502W7; -.
DR OMA; HSKPPSG; -.
DR OrthoDB; 1092113at2759; -.
DR PhylomeDB; Q502W7; -.
DR TreeFam; TF328835; -.
DR PathwayCommons; Q502W7; -.
DR SignaLink; Q502W7; -.
DR BioGRID-ORCS; 120935; 29 hits in 1066 CRISPR screens.
DR GenomeRNAi; 120935; -.
DR Pharos; Q502W7; Tdark.
DR PRO; PR:Q502W7; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q502W7; protein.
DR Bgee; ENSG00000165972; Expressed in left testis and 100 other tissues.
DR ExpressionAtlas; Q502W7; baseline and differential.
DR Genevisible; Q502W7; HS.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR InterPro; IPR025252; DUF4200.
DR Pfam; PF13863; DUF4200; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..563
FT /note="Coiled-coil domain-containing protein 38"
FT /id="PRO_0000234490"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 129..212
FT /evidence="ECO:0000255"
FT COILED 384..415
FT /evidence="ECO:0000255"
FT COILED 497..522
FT /evidence="ECO:0000255"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 36
FT /note="V -> F (in dbSNP:rs12368787)"
FT /id="VAR_056778"
FT VARIANT 227
FT /note="M -> V (in dbSNP:rs10859974)"
FT /id="VAR_056779"
FT CONFLICT 530
FT /note="R -> Q (in Ref. 1; BAC05038)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 563 AA; 65315 MW; 1B1EAC0005CC4B47 CRC64;
MSSNLLPTLN SGGKVKDGST KEDRPYKIFF RDLFLVKENE MAAKETEKFM NRNMKVYQKT
TFSSRMKSHS YLSQLAFYPK RSGRSFEKFG PGPAPIPRLI EGSDTKRTVH EFINDQRDRF
LLEYALSTKR NTIKKFEKDI AMRERQLKKA EKKLQDDALA FEEFLRENDQ RSVDALKMAA
QETINKLQMT AELKKASMEV QAVKSEIAKT EFLLREYMKY GFFLLQMSPK HWQIQQALKR
AQASKSKANI ILPKILAKLS LHSSNKEGIL EESGRTAVLS EDASQGRDSQ GKPSRSLTRT
PEKKKSNLAE SFGSEDSLEF LLDDEMDVDL EPALYFKEPE ELLQVLRELE EQNLTLFQYS
QDVDENLEEV NKREKVIQDK TNSNIEFLLE QEKMLKANCV REEEKAAELQ LKSKLFSFGE
FNSDAQEILI DSLSKKITQV YKVCIGDAED DGLNPIQKLV KVESRLVELC DLIESIPKEN
VEAIERMKQK EWRQKFRDEK MKEKQRHQQE RLKAALEKAV AQPKKKLGRR LVFHSKPPSG
NKQQLPLVNE TKTKSQEEEY FFT
