CCD38_MOUSE
ID CCD38_MOUSE Reviewed; 563 AA.
AC Q8CDN8; Q8CDD6; Q8CDE1;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Coiled-coil domain-containing protein 38;
GN Name=Ccdc38;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q502W7}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CDN8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CDN8-2; Sequence=VSP_018331, VSP_018332;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK029803; BAC26623.1; -; mRNA.
DR EMBL; AK030198; BAC26836.1; -; mRNA.
DR EMBL; AK030205; BAC26841.1; -; mRNA.
DR CCDS; CCDS24127.1; -. [Q8CDN8-1]
DR CCDS; CCDS88074.1; -. [Q8CDN8-2]
DR RefSeq; NP_780697.2; NM_175488.6. [Q8CDN8-1]
DR RefSeq; XP_006513692.1; XM_006513629.2.
DR AlphaFoldDB; Q8CDN8; -.
DR SMR; Q8CDN8; -.
DR STRING; 10090.ENSMUSP00000089860; -.
DR PhosphoSitePlus; Q8CDN8; -.
DR PaxDb; Q8CDN8; -.
DR PRIDE; Q8CDN8; -.
DR ProteomicsDB; 265362; -. [Q8CDN8-1]
DR ProteomicsDB; 265363; -. [Q8CDN8-2]
DR Antibodypedia; 49794; 112 antibodies from 15 providers.
DR DNASU; 237465; -.
DR Ensembl; ENSMUST00000092215; ENSMUSP00000089860; ENSMUSG00000036168. [Q8CDN8-1]
DR Ensembl; ENSMUST00000132214; ENSMUSP00000150407; ENSMUSG00000036168. [Q8CDN8-2]
DR GeneID; 237465; -.
DR KEGG; mmu:237465; -.
DR UCSC; uc007guu.1; mouse. [Q8CDN8-1]
DR UCSC; uc007guv.1; mouse. [Q8CDN8-2]
DR CTD; 120935; -.
DR MGI; MGI:2444738; Ccdc38.
DR VEuPathDB; HostDB:ENSMUSG00000036168; -.
DR eggNOG; ENOG502QSDI; Eukaryota.
DR GeneTree; ENSGT00940000153110; -.
DR HOGENOM; CLU_026271_1_0_1; -.
DR InParanoid; Q8CDN8; -.
DR OMA; HSKPPSG; -.
DR OrthoDB; 1092113at2759; -.
DR PhylomeDB; Q8CDN8; -.
DR TreeFam; TF328835; -.
DR BioGRID-ORCS; 237465; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Ccdc38; mouse.
DR PRO; PR:Q8CDN8; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8CDN8; protein.
DR Bgee; ENSMUSG00000036168; Expressed in spermatocyte and 54 other tissues.
DR Genevisible; Q8CDN8; MM.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR InterPro; IPR025252; DUF4200.
DR Pfam; PF13863; DUF4200; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..563
FT /note="Coiled-coil domain-containing protein 38"
FT /id="PRO_0000234492"
FT REGION 265..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 128..211
FT /evidence="ECO:0000255"
FT COILED 361..415
FT /evidence="ECO:0000255"
FT COILED 454..522
FT /evidence="ECO:0000255"
FT VAR_SEQ 2..101
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_018331"
FT VAR_SEQ 426
FT /note="Q -> QKQAILRQEPTWKAIYFAEKFIEFLLRSISQPVAKKDPFHLPKYIIY
FT QLKRLQNQVKHRSGE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_018332"
FT CONFLICT 91
FT /note="L -> V (in Ref. 1; BAC26836)"
FT /evidence="ECO:0000305"
FT CONFLICT 107
FT /note="R -> S (in Ref. 1; BAC26836)"
FT /evidence="ECO:0000305"
FT CONFLICT 448
FT /note="A -> S (in Ref. 1; BAC26836)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 563 AA; 65835 MW; 2459B0EB751433A4 CRC64;
MASQMHTSIS SGDEGKDAVL KKERPYKIFF KDLFVFKENE IAARKKERMK NHSMKIYQKT
TFSSRMKSRS HLGQLAFFAD AGSSSYERLG LDPTLILRLT EGADRKRTVH EFINDQRDRF
LLEYTVSTKK KTIKRFERLI AIKENQLKKA EKKLQDDALS FEEFLRENDQ RSVDALKMAA
QETINKLQMT SELKKASMEV QSIKSDIAKT EFLLKEYMKY GFFLLKLSPK QWQIQQSQKR
AQSSKSNHIL PKILEKFSIN TAKGDNSIDS DKMSVSEEWS SRRGSQGGRH GKHTLGQDSR
KSSGFTRPES MASEDSLEYF LEDELVEFDL LPEIYFKEPE ELLQVFTELE EQNLTLVQYS
QDVDENLEDV NKREKFIQDK INNNISFLLE HKHMLRMNCE REEEKAAELE LRSRLFSFGE
FNSDAQEKLI DSLSKKINQV YRVCIGDAEV GSLNAVQKLV KVESRLVELS DLIESIPREH
VEAIERLKQK ERRQKLREEK MKEKQRHQEE RLKAALERAV AQPKKKLGRR LIYRSKPQSA
DKQELLLVSD TRSKSQDEEY FFS
