ID   CCD39_BOVIN             Reviewed;         942 AA.
AC   E1BM70;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Coiled-coil domain-containing protein 39 {ECO:0000305};
GN   Name=CCDC39;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
CC   -!- FUNCTION: Required for assembly of dynein regulatory complex (DRC) and
CC       inner dynein arm (IDA) complexes, which are responsible for ciliary
CC       beat regulation, thereby playing a central role in motility in cilia
CC       and flagella. Probably acts together with CCDC40 to form a molecular
CC       ruler that determines the 96 nanometer (nm) repeat length and
CC       arrangements of components in cilia and flagella. Not required for
CC       outer dynein arm complexes assembly. {ECO:0000250|UniProtKB:A8IQT2,
CC       ECO:0000250|UniProtKB:Q9UFE4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q9UFE4}. Note=CCDC40 is required for
CC       localization to axonemes. {ECO:0000250|UniProtKB:Q9UFE4}.
CC   -!- SIMILARITY: Belongs to the CCDC39 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFC03091252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAFC03113262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E1BM70; -.
DR   SMR; E1BM70; -.
DR   STRING; 9913.ENSBTAP00000056529; -.
DR   PaxDb; E1BM70; -.
DR   PRIDE; E1BM70; -.
DR   eggNOG; ENOG502QS0D; Eukaryota.
DR   InParanoid; E1BM70; -.
DR   OrthoDB; 355514at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0060285; P:cilium-dependent cell motility; ISS:UniProtKB.
DR   GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; ISS:UniProtKB.
DR   GO; GO:0036159; P:inner dynein arm assembly; IEA:InterPro.
DR   InterPro; IPR033290; CCDC39.
DR   PANTHER; PTHR18962; PTHR18962; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..942
FT                   /note="Coiled-coil domain-containing protein 39"
FT                   /id="PRO_0000405815"
FT   REGION          868..942
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          16..124
FT                   /evidence="ECO:0000255"
FT   COILED          164..424
FT                   /evidence="ECO:0000255"
FT   COILED          457..605
FT                   /evidence="ECO:0000255"
FT   COILED          729..768
FT                   /evidence="ECO:0000255"
FT   COILED          796..826
FT                   /evidence="ECO:0000255"
FT   MOD_RES         894
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D5Y1"
FT   MOD_RES         902
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D5Y1"
SQ   SEQUENCE   942 AA;  110372 MW;  F6C000297119B2A1 CRC64;
     MSSEFLAELR WEDGFAIPVA NEENKTLEEQ LSKLQDERSS MQDQLRDYED RINAMTSHFK
     NVKQEFLFTQ SLCKARDHEI ESEEHFKMIA ERELGRVKDE IQRLENEITS IREKKNDKEN
     SIFKTTQKLD GLKCQMNWDQ QALEAWLEES AHKDSDALTL QKYAQQDDNK IRALTLQLER
     LTVECNQRRK VLDNEFAETL SVQLELDKAA QDFRKIHNER QKLILQWEST IEQMQKRDKD
     IDNCAVALAR IKQEIREKEN LVKEKIKFLE NEIGNNTEYE KKISVADRKV LKCRTEYQRH
     EANRIQLKDE LDSLKATVNR SSSDLEALRK NISKVKMDIN EETARLGKIK NHNQIVRKKL
     KEITEKTMSV EEKATNLEDM LREEERGVKE VEVQLNIVKD VLFKKVQELQ TETMKEKALV
     SEIEGTRSSL KHLNHQLHKL DFETLQQQEI MYAQDFYIQQ VERRMSRLKG DINSEEKQAL
     EAKTVELQKT LEEKKSALCL LETQIKKLHN DLYFTKKSNS KYRDEKQSLM TKINELTLFN
     DRSEKELTKA KALKQDLMIE DNLLKLEVKR TRELLHSKAE EVLSLEKRKQ QLHTAMEERT
     EEIKVHKTML ASQIRYVDQE RQNVSAEFHE RLSKIDKLKN RYEILTVVML PPEGEEEKTQ
     AYYVIKQALV NNQMEKTGRS YEEEYSFVPM RIYDLVNQVQ EINAWCCMSV PRSFQKVTPS
     SAEYEVKIQL EEQKRAVDEK YRYKQRQIRE LQEDIQSMEN TLTVIEHLTN NVKEKVTEKQ
     AYVLQLNRET EEQKPKLERV TKQCAKLTKE VRLLKDTKDE TLEEQDIKLR EVKQLHKIID
     EMIVDITQEN AEIGVILQTY FQQSGLELPT TSTKGSRHSS RSPSQTSLLS ARSSKSTSTS
     ASQTSIKVLE LNFPASPLTG STSRPTSASS ASSTGKSRKT NK