CCD39_MOUSE
ID CCD39_MOUSE Reviewed; 937 AA.
AC Q9D5Y1; B2RSM0; Q8CDG6;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Coiled-coil domain-containing protein 39 {ECO:0000305};
GN Name=Ccdc39 {ECO:0000312|MGI:MGI:1289263};
GN Synonyms=D3Ertd789e {ECO:0000312|MGI:MGI:1289263};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-888 AND SER-896, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=21131972; DOI=10.1038/ng.726;
RA Merveille A.C., Davis E.E., Becker-Heck A., Legendre M., Amirav I.,
RA Bataille G., Belmont J., Beydon N., Billen F., Clement A., Clercx C.,
RA Coste A., Crosbie R., de Blic J., Deleuze S., Duquesnoy P., Escalier D.,
RA Escudier E., Fliegauf M., Horvath J., Hill K., Jorissen M., Just J.,
RA Kispert A., Lathrop M., Loges N.T., Marthin J.K., Momozawa Y.,
RA Montantin G., Nielsen K.G., Olbrich H., Papon J.F., Rayet I., Roger G.,
RA Schmidts M., Tenreiro H., Towbin J.A., Zelenika D., Zentgraf H.,
RA Georges M., Lequarre A.S., Katsanis N., Omran H., Amselem S.;
RT "CCDC39 is required for assembly of inner dynein arms and the dynein
RT regulatory complex and for normal ciliary motility in humans and dogs.";
RL Nat. Genet. 43:72-78(2011).
CC -!- FUNCTION: Required for assembly of dynein regulatory complex (DRC) and
CC inner dynein arm (IDA) complexes, which are responsible for ciliary
CC beat regulation, thereby playing a central role in motility in cilia
CC and flagella. Probably acts together with CCDC40 to form a molecular
CC ruler that determines the 96 nanometer (nm) repeat length and
CC arrangements of components in cilia and flagella. Not required for
CC outer dynein arm complexes assembly. {ECO:0000250|UniProtKB:A8IQT2,
CC ECO:0000250|UniProtKB:Q9UFE4}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q9UFE4}. Note=CCDC40 is required for
CC localization to axonemes. {ECO:0000250|UniProtKB:Q9UFE4}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in tissues rich in ciliated
CC cells. Expressed in olfactory and vomeronasal sensory neurons and the
CC respiratory epithelium. Expressed in node cells carrying motile cilia,
CC in upper and lower airways, and in ependymal and choroid plexus cells.
CC {ECO:0000269|PubMed:21131972}.
CC -!- SIMILARITY: Belongs to the CCDC39 family. {ECO:0000305}.
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DR EMBL; AK030087; BAC26777.1; -; mRNA.
DR EMBL; AK014839; BAB29574.1; -; mRNA.
DR EMBL; CH466530; EDL35029.1; -; Genomic_DNA.
DR EMBL; BC138917; AAI38918.1; -; mRNA.
DR EMBL; BC138920; AAI38921.1; -; mRNA.
DR CCDS; CCDS17304.1; -.
DR RefSeq; NP_080498.1; NM_026222.2.
DR AlphaFoldDB; Q9D5Y1; -.
DR SMR; Q9D5Y1; -.
DR BioGRID; 206277; 3.
DR STRING; 10090.ENSMUSP00000029222; -.
DR iPTMnet; Q9D5Y1; -.
DR PhosphoSitePlus; Q9D5Y1; -.
DR MaxQB; Q9D5Y1; -.
DR PaxDb; Q9D5Y1; -.
DR PRIDE; Q9D5Y1; -.
DR ProteomicsDB; 265364; -.
DR Antibodypedia; 79042; 110 antibodies from 16 providers.
DR DNASU; 51938; -.
DR Ensembl; ENSMUST00000029222; ENSMUSP00000029222; ENSMUSG00000027676.
DR GeneID; 51938; -.
DR KEGG; mmu:51938; -.
DR UCSC; uc008oxi.1; mouse.
DR CTD; 339829; -.
DR MGI; MGI:1289263; Ccdc39.
DR VEuPathDB; HostDB:ENSMUSG00000027676; -.
DR eggNOG; ENOG502QS0D; Eukaryota.
DR GeneTree; ENSGT00390000015010; -.
DR HOGENOM; CLU_009793_2_0_1; -.
DR InParanoid; Q9D5Y1; -.
DR OMA; LYRTQRQ; -.
DR OrthoDB; 355514at2759; -.
DR PhylomeDB; Q9D5Y1; -.
DR TreeFam; TF329312; -.
DR BioGRID-ORCS; 51938; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Ccdc39; mouse.
DR PRO; PR:Q9D5Y1; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9D5Y1; protein.
DR Bgee; ENSMUSG00000027676; Expressed in spermatocyte and 196 other tissues.
DR Genevisible; Q9D5Y1; MM.
DR GO; GO:0097729; C:9+2 motile cilium; EXP:MGI.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISO:MGI.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR GO; GO:0007420; P:brain development; IMP:MGI.
DR GO; GO:0090660; P:cerebrospinal fluid circulation; IMP:MGI.
DR GO; GO:0003341; P:cilium movement; ISO:MGI.
DR GO; GO:0060285; P:cilium-dependent cell motility; ISS:UniProtKB.
DR GO; GO:0071907; P:determination of digestive tract left/right asymmetry; ISO:MGI.
DR GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI.
DR GO; GO:0071910; P:determination of liver left/right asymmetry; ISO:MGI.
DR GO; GO:0035469; P:determination of pancreatic left/right asymmetry; ISO:MGI.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; ISS:UniProtKB.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IMP:MGI.
DR GO; GO:0061966; P:establishment of left/right asymmetry; IMP:MGI.
DR GO; GO:0051649; P:establishment of localization in cell; IMP:MGI.
DR GO; GO:0030317; P:flagellated sperm motility; ISO:MGI.
DR GO; GO:0007507; P:heart development; IMP:MGI.
DR GO; GO:0001947; P:heart looping; ISO:MGI.
DR GO; GO:0036159; P:inner dynein arm assembly; IMP:MGI.
DR GO; GO:0030324; P:lung development; ISO:MGI.
DR GO; GO:0044458; P:motile cilium assembly; ISO:MGI.
DR GO; GO:0061512; P:protein localization to cilium; IMP:MGI.
DR GO; GO:0003356; P:regulation of cilium beat frequency; ISO:MGI.
DR InterPro; IPR033290; CCDC39.
DR PANTHER; PTHR18962; PTHR18962; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..937
FT /note="Coiled-coil domain-containing protein 39"
FT /id="PRO_0000234494"
FT REGION 866..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 16..137
FT /evidence="ECO:0000255"
FT COILED 165..339
FT /evidence="ECO:0000255"
FT COILED 365..615
FT /evidence="ECO:0000255"
FT COILED 664..816
FT /evidence="ECO:0000255"
FT COMPBIAS 867..900
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 888
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 896
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 183
FT /note="M -> L (in Ref. 1; BAC26777)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="D -> H (in Ref. 1; BAC26777)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 937 AA; 110072 MW; D8FA9D3A9CC52393 CRC64;
MCSEFLSELH WEDGFAIPVA NQENKILEDQ LAKLREEKSN LQDQLHDYEE RINSMTSHLK
NVNQEFLFTQ SLYKARESEI ESEEHFKAIA ERELGRVKNE TQLLEKEMAI IRERKSQMEN
NIFKTTQKLD DLKCQMNWDQ QALEAWLEES AHKDSDSLTL QKYSQQDDNK IRALTLQLEK
LTMEYNEKRK LLDSELTETL SAQLELDKAA QDFRKIHLER QELIQQWENT IEQMQRRDQE
IDNCALALSR IKQEAREKEG VVKEKIKFLE NEVENNIEYE RKISVAERKV SKCRMDYQRH
EGNRSQLKDE LDTLKTTLNR TSSDLQALRK NISKVKKDIF DETLRLQKLK HHNEVVKHKL
KMITEKTLSI EEKATNMEDM LKEEEKGLKE VEVQLGIVKD VLFKKVQELQ NEIAKEKALV
SEIEGTRSSL KHLNKQLHKL DFETLKQQEI MYSQDFYIQQ VERRMSRLKG EINSEEKQAL
EAKILELKKT MDEKKSTLSL LESQIKKLHN DLYFIKKSNG KNNDEKESLM NKISELNLFI
DRSEKELSKA KAVKEDMMIE DNLLKLQVKR ARELLYSKAE EVLSLEKRKQ QLGKDMEERA
EEIKVHKAML TSQIRCVEQQ RKTMSSEFHE RLSKIDKLKN RYEILTVVML PPEGEEEKTQ
SYYVIKAAQE KEELQREGDS LDAKINKAEK EIYALQNTLQ VLNSCNSNYK QSFKKVTPSS
DEYALKIQLE EQKRTADERY RCKQRQIREL QEDIQSMENT FEVIGHLANN AKEKLTEKQT
LAFQLRKETE EQKPKLQRIT KQCGRLRREI RILKQTDNET LEEQDIQLRE IIQFHKDIDQ
MLVNAMENAE IHAIFKTYFE QNGLELPTAR GPSSRSSSQS SSLSSFRSLE DVTLQSPPTA
KVIQLRFPEP PPATNDSSRS ASSGSNSNIP KEKKLSK
