CCD39_RAT
ID CCD39_RAT Reviewed; 934 AA.
AC D3Z8K2; D4A2M2;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Coiled-coil domain-containing protein 39 {ECO:0000305};
GN Name=Ccdc39;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for assembly of dynein regulatory complex (DRC) and
CC inner dynein arm (IDA) complexes, which are responsible for ciliary
CC beat regulation, thereby playing a central role in motility in cilia
CC and flagella. Probably acts together with CCDC40 to form a molecular
CC ruler that determines the 96 nanometer (nm) repeat length and
CC arrangements of components in cilia and flagella. Not required for
CC outer dynein arm complexes assembly. {ECO:0000250|UniProtKB:A8IQT2,
CC ECO:0000250|UniProtKB:Q9UFE4}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q9UFE4}. Note=CCDC40 is required for
CC localization to axonemes. {ECO:0000250|UniProtKB:Q9UFE4}.
CC -!- SIMILARITY: Belongs to the CCDC39 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDM01224.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH473961; EDM01225.1; -; Genomic_DNA.
DR EMBL; CH473961; EDM01224.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; NP_001101137.1; NM_001107667.1.
DR RefSeq; XP_017446344.1; XM_017590855.1.
DR AlphaFoldDB; D3Z8K2; -.
DR SMR; D3Z8K2; -.
DR STRING; 10116.ENSRNOP00000061948; -.
DR PaxDb; D3Z8K2; -.
DR PRIDE; D3Z8K2; -.
DR Ensembl; ENSRNOT00000084521; ENSRNOP00000069773; ENSRNOG00000011440.
DR GeneID; 310315; -.
DR KEGG; rno:310315; -.
DR CTD; 339829; -.
DR RGD; 1306277; Ccdc39.
DR eggNOG; ENOG502QS0D; Eukaryota.
DR GeneTree; ENSGT00390000015010; -.
DR HOGENOM; CLU_009793_2_0_1; -.
DR InParanoid; D3Z8K2; -.
DR OMA; LYRTQRQ; -.
DR OrthoDB; 355514at2759; -.
DR PhylomeDB; D3Z8K2; -.
DR TreeFam; TF329312; -.
DR PRO; PR:D3Z8K2; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Proteomes; UP000234681; Chromosome 2.
DR Bgee; ENSRNOG00000011440; Expressed in testis and 19 other tissues.
DR ExpressionAtlas; D3Z8K2; baseline and differential.
DR GO; GO:0097729; C:9+2 motile cilium; ISO:RGD.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISO:RGD.
DR GO; GO:0005829; C:cytosol; ISO:RGD.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR GO; GO:0007420; P:brain development; ISO:RGD.
DR GO; GO:0090660; P:cerebrospinal fluid circulation; ISO:RGD.
DR GO; GO:0003341; P:cilium movement; ISO:RGD.
DR GO; GO:0060285; P:cilium-dependent cell motility; ISS:UniProtKB.
DR GO; GO:0071907; P:determination of digestive tract left/right asymmetry; ISO:RGD.
DR GO; GO:0007368; P:determination of left/right symmetry; ISO:RGD.
DR GO; GO:0071910; P:determination of liver left/right asymmetry; ISO:RGD.
DR GO; GO:0035469; P:determination of pancreatic left/right asymmetry; ISO:RGD.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; ISS:UniProtKB.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; ISO:RGD.
DR GO; GO:0061966; P:establishment of left/right asymmetry; ISO:RGD.
DR GO; GO:0051649; P:establishment of localization in cell; ISO:RGD.
DR GO; GO:0030317; P:flagellated sperm motility; ISO:RGD.
DR GO; GO:0007507; P:heart development; ISO:RGD.
DR GO; GO:0001947; P:heart looping; ISO:RGD.
DR GO; GO:0036159; P:inner dynein arm assembly; ISO:RGD.
DR GO; GO:0030324; P:lung development; ISO:RGD.
DR GO; GO:0044458; P:motile cilium assembly; ISO:RGD.
DR GO; GO:0061512; P:protein localization to cilium; ISO:RGD.
DR GO; GO:0003356; P:regulation of cilium beat frequency; ISO:RGD.
DR InterPro; IPR033290; CCDC39.
DR PANTHER; PTHR18962; PTHR18962; 1.
PE 3: Inferred from homology;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..934
FT /note="Coiled-coil domain-containing protein 39"
FT /id="PRO_0000405817"
FT REGION 866..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 17..133
FT /evidence="ECO:0000255"
FT COILED 164..512
FT /evidence="ECO:0000255"
FT COILED 540..615
FT /evidence="ECO:0000255"
FT COILED 664..826
FT /evidence="ECO:0000255"
FT COMPBIAS 866..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..934
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 887
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D5Y1"
FT MOD_RES 895
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D5Y1"
SQ SEQUENCE 934 AA; 109555 MW; 3CE2557465F699CD CRC64;
MSSEFLSELH WEDGFAIPVA NQENKILEDQ LAKLHKEKSN LQDQLRDYED RINSMSSHLK
NVNQEFLFTQ SLYKARECEI ESEEHFKAIA ERELGRVKDE IQQLEKEMAI ILERKNDKEN
AIFKATQKLD GLKCQMNWDQ QALEAWLEES AHKDSDSLTL QKYSQQDNNK IRALTLKLEK
LTMECNEKRK LLDNELTETL SAQLELDKAA QDFRKIHVER QELIQQWENT IEQMQRRDQE
IDNCALALAR IKQEAREKEG VVREKIKFLE NEVGNNVEYE RRISIAERKV SKCRMEYQRQ
EANRNQLKDE LDTLKTTLNR TSSDLEALRK NISKVKKDIL DETGRLQKLK HHNEIVKHKL
KMITEKTISI EEKATNMEDM LKEEEKNLKE VEVQLNIVKG VLFKKVQELQ SAITKEKALG
SEIEGTRSSL KHLNQRLHKL DFETLKQQEI MYSQDFYIQQ VERRMSRLKG EINSEEKQAL
EVKIVELRKT MEERKSTLSL LEEQIKKLHN DLYFIKKSNG KNKDEKESLM NKIGELHLFV
DRSEKELNKA KAVKEDLMIE DNLLKLQVKR ARELLYSKAE EVLSLEKRKQ QLCTAMEERV
EEIKVHKAML TSQIRYVDQQ RQTVSSEFHE RLSKIDKLKN RYEILTVVML PPEGEEEKTQ
SYYVIKAAQE KEELQREGDS LDAKISKAEK EIYALQNTLQ VLSSCNNNYK QSFKKVTPSS
DEYGIKIQLE EQKRSADEKY RCKQRQIREL QEDIQSMENT FEVIEHLANN AREKLSEKQT
LSFQLRKETE EQKPKIQRVT KQCGRLRREI RILRQTNDET LEEQDIQLRE IIQFHKDIDQ
MLVNAMENAE IHVIFQTYFQ QNGLELPTAK GPSSRSSSQS SLSSIRSLED SIPISPPTAK
VIELRFPGPP ARSDSSRSSS GSNSNIPKGK KLNK
