ID   CCD39_XENTR             Reviewed;         945 AA.
AC   Q0V9R4;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Coiled-coil domain-containing protein 39;
GN   Name=ccdc39;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for assembly of dynein regulatory complex (DRC) and
CC       inner dynein arm (IDA) complexes, which are responsible for ciliary
CC       beat regulation, thereby playing a central role in motility in cilia
CC       and flagella. Probably acts together with ccdc40 to form a molecular
CC       ruler that determines the 96 nanometer (nm) repeat length and
CC       arrangements of components in cilia and flagella. Not required for
CC       outer dynein arm complexes assembly. {ECO:0000250|UniProtKB:A8IQT2,
CC       ECO:0000250|UniProtKB:Q9UFE4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q9UFE4}.
CC   -!- SIMILARITY: Belongs to the CCDC39 family. {ECO:0000305}.
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DR   EMBL; BC121424; AAI21425.1; -; mRNA.
DR   RefSeq; NP_001072342.1; NM_001078874.1.
DR   AlphaFoldDB; Q0V9R4; -.
DR   SMR; Q0V9R4; -.
DR   STRING; 8364.ENSXETP00000033721; -.
DR   PaxDb; Q0V9R4; -.
DR   GeneID; 779795; -.
DR   KEGG; xtr:779795; -.
DR   CTD; 339829; -.
DR   Xenbase; XB-GENE-989047; ccdc39.
DR   eggNOG; ENOG502QS0D; Eukaryota.
DR   InParanoid; Q0V9R4; -.
DR   OrthoDB; 355514at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; IBA:GO_Central.
DR   GO; GO:0060285; P:cilium-dependent cell motility; ISS:UniProtKB.
DR   GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; ISS:UniProtKB.
DR   GO; GO:0036159; P:inner dynein arm assembly; IBA:GO_Central.
DR   InterPro; IPR033290; CCDC39.
DR   PANTHER; PTHR18962; PTHR18962; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..945
FT                   /note="Coiled-coil domain-containing protein 39"
FT                   /id="PRO_0000405819"
FT   REGION          871..945
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          16..535
FT                   /evidence="ECO:0000255"
FT   COILED          584..604
FT                   /evidence="ECO:0000255"
FT   COILED          666..826
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        871..906
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        919..945
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   945 AA;  110476 MW;  7B4D648FF4048444 CRC64;
     MNRKVLDELR WDDGYAIPVA NAENKTLEEE MQKKEKEKIQ LSNQVKGFEE RIQAMADHLR
     NVRQELTYTQ SLVRARENET ESEEHFKTLS EREIGRLKQE IQRLENELVS LREKKNSHEN
     NIFKTTQKLE NLKRQLNWDQ QTLEAWLEES ARKDEDSMAI QKYSQKDDGK IKELSLLIEK
     LTLEAGQKRK LMDNELTETI TAQIELDKTA EDFRKAHTER QQLISQWEST IGQMQKRDRD
     IDHCAMLLAQ VKQELREKES IIKEKIQFLQ SEIDNNKEYE KKISAAERQA AKLRLELQEQ
     EIIRGRLQDE LDSLKGVVDR TASDLETMRT EVTSLKKDIR NRQNRLQMAQ EYNDGLSDKL
     NFVTESALSL EERALRMEEM FKEQEKTVKD LEVQLKQIRE ILFKKSQELH ECKAKEKDVI
     AEINGGQVTL KNLNSQLQKL DSHALKQQGI MYNQDFQIQQ LERRLSRLKG EVNTDEKQAL
     EMRVSQLTKV FEERRAALKL LNTQHKKLQG DVRYIKRELE KTGQEKGDLI SKKEEFNLFN
     MMSEKTLKKI KASKQDLMVE DNILKLEIKR LRDMLYSKAD DVFSLEKRKL QLQTAMKERT
     EEISVHKEML KSHIRYVDQE RQNISSQLHE RLAKVEKMRK RFEILTIAMM PPEGEEEKSQ
     AYYVVKAAQE KEELQRVGDD LDGKIRKAEK EIRALENTLR VINGCNTSFK KSFSKITETS
     EEYDEKVQLE EEKKAAEEKH RYKQRQIREL QEDTQVMKNT FDSMINEELS YQEKAKELLP
     AITQLNKETE DQKQKLERVL KQYSKLSKHV RNAKKSKEET QEEKDINVRD LRDFNQSLNK
     MLAQAMEKNP DLATALQLYF HQFGLEIPTI GSTPGSYSSR SSSSRSSTIS VRSGTSRISV
     NSGQSPRIKV VDLGLPPACP SSNVSSARSS RTSSRSGSSK SQKQE