位置:首页 > 蛋白库 > CCD40_MOUSE
CCD40_MOUSE
ID   CCD40_MOUSE             Reviewed;        1192 AA.
AC   Q8BI79; A2AFL0; Q5U4C0; Q8BI59;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Coiled-coil domain-containing protein 40 {ECO:0000305};
DE   AltName: Full=Protein links {ECO:0000303|PubMed:21131972};
GN   Name=Ccdc40 {ECO:0000312|MGI:MGI:2443893};
GN   Synonyms=Lnks {ECO:0000303|PubMed:21131972};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC   STRAIN=C57BL/6J; TISSUE=Cerebellum, and Oviduct;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Lung, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [5]
RP   SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX   PubMed=21131972; DOI=10.1038/ng.726;
RA   Merveille A.C., Davis E.E., Becker-Heck A., Legendre M., Amirav I.,
RA   Bataille G., Belmont J., Beydon N., Billen F., Clement A., Clercx C.,
RA   Coste A., Crosbie R., de Blic J., Deleuze S., Duquesnoy P., Escalier D.,
RA   Escudier E., Fliegauf M., Horvath J., Hill K., Jorissen M., Just J.,
RA   Kispert A., Lathrop M., Loges N.T., Marthin J.K., Momozawa Y.,
RA   Montantin G., Nielsen K.G., Olbrich H., Papon J.F., Rayet I., Roger G.,
RA   Schmidts M., Tenreiro H., Towbin J.A., Zelenika D., Zentgraf H.,
RA   Georges M., Lequarre A.S., Katsanis N., Omran H., Amselem S.;
RT   "CCDC39 is required for assembly of inner dynein arms and the dynein
RT   regulatory complex and for normal ciliary motility in humans and dogs.";
RL   Nat. Genet. 43:72-78(2011).
CC   -!- FUNCTION: Required for assembly of dynein regulatory complex (DRC) and
CC       inner dynein arm (IDA) complexes, which are responsible for ciliary
CC       beat regulation, thereby playing a central role in motility in cilia
CC       and flagella. Probably acts together with CCDC39 to form a molecular
CC       ruler that determines the 96 nanometer (nm) repeat length and
CC       arrangements of components in cilia and flagella. Not required for
CC       outer dynein arm complexes assembly. Required for axonemal recruitment
CC       of CCDC39. {ECO:0000250|UniProtKB:A8IQT2,
CC       ECO:0000250|UniProtKB:Q4G0X9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21131972}. Cell
CC       projection, cilium {ECO:0000269|PubMed:21131972}. Note=Localizes to
CC       cytoplasm and motile cilium. {ECO:0000269|PubMed:21131972}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q8BI79-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8BI79-2; Sequence=VSP_028310, VSP_028312;
CC       Name=3;
CC         IsoId=Q8BI79-3; Sequence=VSP_028311, VSP_028313, VSP_028314;
CC   -!- TISSUE SPECIFICITY: Specifically expressed in the embryonic node and
CC       midline. {ECO:0000269|PubMed:21131972}.
CC   -!- DISRUPTION PHENOTYPE: Defects are the cause of the lnks phenotype, a
CC       phenotype related to primary ciliary dyskinesia (PCD). PCD is
CC       characterized by recurrent respiratory infections, situs inversus and
CC       ciliary immotility and hydrocephalus. The length of the cilia
CC       projecting from the nodal pit cells in mutants is drastically reduced.
CC       {ECO:0000269|PubMed:21131972}.
CC   -!- SIMILARITY: Belongs to the CCDC40 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH85159.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK046971; BAC32932.1; -; mRNA.
DR   EMBL; AK054172; BAC35680.1; -; mRNA.
DR   EMBL; AL672140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC085159; AAH85159.1; ALT_INIT; mRNA.
DR   RefSeq; NP_780639.1; NM_175430.4.
DR   AlphaFoldDB; Q8BI79; -.
DR   SMR; Q8BI79; -.
DR   STRING; 10090.ENSMUSP00000039463; -.
DR   iPTMnet; Q8BI79; -.
DR   PhosphoSitePlus; Q8BI79; -.
DR   MaxQB; Q8BI79; -.
DR   PaxDb; Q8BI79; -.
DR   PRIDE; Q8BI79; -.
DR   ProteomicsDB; 283729; -. [Q8BI79-1]
DR   ProteomicsDB; 283730; -. [Q8BI79-2]
DR   ProteomicsDB; 283731; -. [Q8BI79-3]
DR   Antibodypedia; 9999; 55 antibodies from 15 providers.
DR   Ensembl; ENSMUST00000053440; ENSMUSP00000062198; ENSMUSG00000039963. [Q8BI79-3]
DR   UCSC; uc007mqc.1; mouse. [Q8BI79-1]
DR   UCSC; uc007mqe.1; mouse. [Q8BI79-3]
DR   MGI; MGI:2443893; Ccdc40.
DR   VEuPathDB; HostDB:ENSMUSG00000039963; -.
DR   eggNOG; ENOG502QQ91; Eukaryota.
DR   GeneTree; ENSGT00440000035688; -.
DR   HOGENOM; CLU_008826_0_0_1; -.
DR   InParanoid; Q8BI79; -.
DR   OrthoDB; 323186at2759; -.
DR   PhylomeDB; Q8BI79; -.
DR   TreeFam; TF325559; -.
DR   BioGRID-ORCS; 207607; 5 hits in 74 CRISPR screens.
DR   ChiTaRS; Ccdc40; mouse.
DR   PRO; PR:Q8BI79; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8BI79; protein.
DR   Bgee; ENSMUSG00000039963; Expressed in ventricular system choroidal fissure and 90 other tissues.
DR   ExpressionAtlas; Q8BI79; baseline and differential.
DR   Genevisible; Q8BI79; MM.
DR   GO; GO:0005930; C:axoneme; ISO:MGI.
DR   GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0031514; C:motile cilium; IDA:MGI.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0035082; P:axoneme assembly; IMP:MGI.
DR   GO; GO:0003341; P:cilium movement; IMP:UniProtKB.
DR   GO; GO:0071907; P:determination of digestive tract left/right asymmetry; ISO:MGI.
DR   GO; GO:0007368; P:determination of left/right symmetry; IGI:MGI.
DR   GO; GO:0071910; P:determination of liver left/right asymmetry; ISO:MGI.
DR   GO; GO:0035469; P:determination of pancreatic left/right asymmetry; ISO:MGI.
DR   GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IMP:UniProtKB.
DR   GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; ISO:MGI.
DR   GO; GO:0030317; P:flagellated sperm motility; ISO:MGI.
DR   GO; GO:0001947; P:heart looping; ISO:MGI.
DR   GO; GO:0036159; P:inner dynein arm assembly; ISO:MGI.
DR   GO; GO:0030324; P:lung development; IMP:BHF-UCL.
DR   GO; GO:0044458; P:motile cilium assembly; ISO:MGI.
DR   GO; GO:0061512; P:protein localization to cilium; IMP:MGI.
DR   GO; GO:0003356; P:regulation of cilium beat frequency; ISO:MGI.
DR   InterPro; IPR037386; CCDC40.
DR   PANTHER; PTHR16275; PTHR16275; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell projection; Ciliopathy; Cilium; Coiled coil;
KW   Cytoplasm; Phosphoprotein; Primary ciliary dyskinesia; Reference proteome.
FT   CHAIN           1..1192
FT                   /note="Coiled-coil domain-containing protein 40"
FT                   /id="PRO_0000305251"
FT   REGION          1..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          126..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          173..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          211..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          261..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          308..369
FT                   /evidence="ECO:0000255"
FT   COILED          425..451
FT                   /evidence="ECO:0000255"
FT   COILED          581..649
FT                   /evidence="ECO:0000255"
FT   COILED          733..768
FT                   /evidence="ECO:0000255"
FT   COILED          830..871
FT                   /evidence="ECO:0000255"
FT   COILED          919..972
FT                   /evidence="ECO:0000255"
FT   COILED          1044..1118
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        54..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         306
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   VAR_SEQ         1
FT                   /note="M -> MAEPEDQADGRSQQEGQQSSAEEDSEQQYTEGPEVSPQLEDNGQEID
FT                   EGRDPTRSPEEDITTEGGGGSEGEM (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_028310"
FT   VAR_SEQ         1
FT                   /note="M -> MAEPEDQADGSQQEGQQSSAEEDSEQQYTEGPEVSPQLEDNGQEIDE
FT                   GRDPTRSPEEDITTEGGGGSEGEM (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_028311"
FT   VAR_SEQ         744..810
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_028312"
FT   VAR_SEQ         1058..1067
FT                   /note="ATDDCTNTIS -> FIFSLLRVCG (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_028313"
FT   VAR_SEQ         1068..1192
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_028314"
FT   CONFLICT        88
FT                   /note="E -> K (in Ref. 3; AAH85159)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        292
FT                   /note="E -> K (in Ref. 1; BAC35680)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        803
FT                   /note="E -> Q (in Ref. 1; BAC35680)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        845
FT                   /note="L -> M (in Ref. 1; BAC35680)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        866
FT                   /note="E -> Q (in Ref. 1; BAC35680)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        884
FT                   /note="R -> G (in Ref. 1; BAC35680)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        940
FT                   /note="S -> A (in Ref. 3; AAH85159)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1192 AA;  136772 MW;  A3BBC5ABA0183A3A CRC64;
     MMDAEKVSTD GEAISEGEVG SNGETPPETE VEFIGETAPD TDVEFIGETS PGTDVEPTGE
     SIQETEVESI GEATPGMDVE PIKKTMTELN VESIGEETSE TDVDSIRKAL RGIDLESITV
     AYPPKKAKHR KVRPQAEVES TGRAAPEGEL EVSDHEKVEA LLDELDELSE IVSSPEVSYS
     DISPLEMGED DTNVSATSTD TFQQGIYEPI EPIEPTEPPE PAEPPKPAET PEDSTVRAPA
     HPYQRDFPMG ARHRFRLSIM GSLTPSDTDD LPLETDEPPQ QESVQSTPRA LEETRIQFLD
     QVQSLSPEAL LDRATEGSDE AEEEGSQLIV LDPDHPLMIR FQEALKGYLN RQMDKLKLDV
     QELDVATKQT RSQRQELGVN LYGVQQHLAR LQMQLEKSHD RHSLVACERR RKEEELQCAR
     SVYNKTCQTA NEERKKLAAL QTEVESLALH LFYMQNIEQD VRDDIQVMKQ VVRKTETEKM
     HAEVEKKKQD LFVDQLTERS HQLEENIALF EAQYLSQAED TRVLKKAVTE AITEIDTIAV
     EKKRILQQWT TSLVGMKHRN EAYKTVMDAL RECQHQVKST DSEIEVCKKS IMQEEEKNEK
     LARLLNRAET EATLVQKMTA QCLSKQEALQ TEFNTYQLAL QDTEEMLNKG YVEHSAVLSE
     LQATRQAFHQ EQELRQKMDM SMVDKLQEQG TSSKMTKYFH QLLRKLQKEN TNLVTHLSKI
     DGDIAQATLD ITNTNCKIDM HKKTLAEMDK EVKRFNDLIT NSESEIARRT ILIERKQSLI
     NFFNKQLEQM VSELGGEEAG PLELEIKRLS KLTEEYNTGV AEAQMTWLRL QQELVQVTHE
     REEQLVSVDQ LKKEVHIMEQ KKLRIESKIA HEKKEQKIVS RHMRDLDNDL SKLNMLLDKN
     RCSSEELEQN NIATETEFLR TLKDSERETI QMQEKLMELS EEKATLLNSF MEAEHQIMLW
     EKKIQLAKEM RSSVDSETGQ TEIRAMKAEI HRMKVRHGQL LKQQEKMIRD MELAVARRET
     IVVQAEGQSK IDKKVITKTE FHYQQRELQK KVREMHKATD DCTNTISELE ETQKFLSSSL
     QEKQQLLSEM QATTDVLEEE INQLTALKRQ NLLEIVTLQT RGKHLQAAIE GKYVFLHRNS
     RSQLMERKRL SVRLSQLNKV LSSVQEDYPQ YQEVLQSIQQ KIATKLETPE PS
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024