CCD42_ARATH
ID CCD42_ARATH Reviewed; 298 AA.
AC Q0WQN9; Q6NKU1; Q9LX96;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Cyclin-D4-2;
DE AltName: Full=G1/S-specific cyclin-D4-2;
DE Short=CycD4;2;
GN Name=CYCD4-2; OrderedLocusNames=At5g10440; ORFNames=F12B17.210;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15208425; DOI=10.1104/pp.104.040436;
RA Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W.,
RA Ma H.;
RT "Genome-wide analysis of the cyclin family in Arabidopsis and comparative
RT phylogenetic analysis of plant cyclin-like proteins.";
RL Plant Physiol. 135:1084-1099(2004).
RN [6]
RP FUNCTION, DEVELOPMENTAL STAGE, AND INTERACTION WITH CDKA-1.
RX PubMed=16408177; DOI=10.1007/s00299-005-0075-4;
RA Kono A., Ohno R., Umeda-Hara C., Uchimiya H., Umeda M.;
RT "A distinct type of cyclin D, CYCD4;2, involved in the activation of cell
RT division in Arabidopsis.";
RL Plant Cell Rep. 25:540-545(2006).
CC -!- FUNCTION: May promote cell division. {ECO:0000269|PubMed:16408177}.
CC -!- SUBUNIT: Interacts with CDKA-1 to form a kinase complex.
CC {ECO:0000269|PubMed:16408177}.
CC -!- DEVELOPMENTAL STAGE: Expressed from the G1 to the S phase.
CC {ECO:0000269|PubMed:16408177}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin D subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB89399.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL353995; CAB89399.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED91540.1; -; Genomic_DNA.
DR EMBL; BT012602; AAT06421.1; -; mRNA.
DR EMBL; BT014959; AAT47810.1; -; mRNA.
DR EMBL; AK228653; BAF00560.1; -; mRNA.
DR PIR; T49995; T49995.
DR RefSeq; NP_196606.3; NM_121082.5.
DR AlphaFoldDB; Q0WQN9; -.
DR SMR; Q0WQN9; -.
DR BioGRID; 16186; 19.
DR IntAct; Q0WQN9; 9.
DR STRING; 3702.AT5G10440.1; -.
DR PaxDb; Q0WQN9; -.
DR PRIDE; Q0WQN9; -.
DR ProteomicsDB; 223871; -.
DR EnsemblPlants; AT5G10440.1; AT5G10440.1; AT5G10440.
DR GeneID; 830908; -.
DR Gramene; AT5G10440.1; AT5G10440.1; AT5G10440.
DR KEGG; ath:AT5G10440; -.
DR Araport; AT5G10440; -.
DR TAIR; locus:2142504; AT5G10440.
DR eggNOG; KOG0656; Eukaryota.
DR HOGENOM; CLU_048040_1_0_1; -.
DR InParanoid; Q0WQN9; -.
DR OMA; REEEHMP; -.
DR OrthoDB; 1234739at2759; -.
DR PhylomeDB; Q0WQN9; -.
DR PRO; PR:Q0WQN9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q0WQN9; baseline and differential.
DR Genevisible; Q0WQN9; AT.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0010440; P:stomatal lineage progression; IMP:TAIR.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
DR PROSITE; PS00292; CYCLINS; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Reference proteome.
FT CHAIN 1..298
FT /note="Cyclin-D4-2"
FT /id="PRO_0000287030"
FT CONFLICT 223
FT /note="A -> T (in Ref. 4; BAF00560)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 298 AA; 33776 MW; F8531CDE4C2F0DFE CRC64;
MAEFMEPNLV SNFDDEKSNS VDTRSIFQMG FPLESEEIVR EMIEKERQHS PRDDYLKRLR
NGDLDFNVRI QALGWIWKAC EELQFGPLCI CLAMNYLDRF LSVHDLPSGK AWTVQLLAVA
CLSLAAKIEE TNVPELMQLQ VGAPMFVFEA KSVQRMELLV LNVLRWRLRA VTPCSYVRYF
LSKINGYDQE PHSRLVTRSL QVIASTTKGI DFLEFRASEI AAAVALSVSG EHFDKFSFSS
SFSSLEKERV KKIGEMIERD GSSSSSQTPN NTVLQFKSRR YSHSLSTASV SSSLTSLS
