CCD43_MOUSE
ID CCD43_MOUSE Reviewed; 222 AA.
AC Q9CR29; Q6PDT2;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Coiled-coil domain-containing protein 43;
GN Name=Ccdc43; Synonyms=D11Ertd707e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo, Skin, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=19131326; DOI=10.1074/mcp.m800451-mcp200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-137, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CR29-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CR29-2; Sequence=VSP_018336, VSP_018337;
CC -!- SIMILARITY: Belongs to the CCDC43 family. {ECO:0000305}.
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DR EMBL; AK009319; BAB26213.1; -; mRNA.
DR EMBL; AK028834; BAC26145.1; -; mRNA.
DR EMBL; AK011254; BAB27496.1; -; mRNA.
DR EMBL; AK166820; BAE39046.1; -; mRNA.
DR EMBL; BC058520; AAH58520.1; -; mRNA.
DR EMBL; BC061076; AAH61076.1; -; mRNA.
DR CCDS; CCDS25502.1; -. [Q9CR29-1]
DR RefSeq; NP_080194.1; NM_025918.3. [Q9CR29-1]
DR AlphaFoldDB; Q9CR29; -.
DR BioGRID; 206753; 3.
DR STRING; 10090.ENSMUSP00000090230; -.
DR iPTMnet; Q9CR29; -.
DR PhosphoSitePlus; Q9CR29; -.
DR EPD; Q9CR29; -.
DR jPOST; Q9CR29; -.
DR MaxQB; Q9CR29; -.
DR PaxDb; Q9CR29; -.
DR PeptideAtlas; Q9CR29; -.
DR PRIDE; Q9CR29; -.
DR ProteomicsDB; 281498; -. [Q9CR29-1]
DR ProteomicsDB; 281499; -. [Q9CR29-2]
DR Antibodypedia; 8262; 76 antibodies from 15 providers.
DR DNASU; 52715; -.
DR Ensembl; ENSMUST00000092569; ENSMUSP00000090230; ENSMUSG00000020925. [Q9CR29-1]
DR GeneID; 52715; -.
DR KEGG; mmu:52715; -.
DR UCSC; uc007lsg.1; mouse. [Q9CR29-1]
DR CTD; 124808; -.
DR MGI; MGI:1289318; Ccdc43.
DR VEuPathDB; HostDB:ENSMUSG00000020925; -.
DR eggNOG; ENOG502RYDM; Eukaryota.
DR GeneTree; ENSGT00390000015009; -.
DR HOGENOM; CLU_079381_1_0_1; -.
DR InParanoid; Q9CR29; -.
DR OMA; AQYSQMS; -.
DR OrthoDB; 1503148at2759; -.
DR PhylomeDB; Q9CR29; -.
DR TreeFam; TF324859; -.
DR BioGRID-ORCS; 52715; 5 hits in 72 CRISPR screens.
DR PRO; PR:Q9CR29; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9CR29; protein.
DR Bgee; ENSMUSG00000020925; Expressed in muscle of arm and 252 other tissues.
DR ExpressionAtlas; Q9CR29; baseline and differential.
DR Genevisible; Q9CR29; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR InterPro; IPR037666; CCDC43.
DR PANTHER; PTHR31684; PTHR31684; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Isopeptide bond; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..222
FT /note="Coiled-coil domain-containing protein 43"
FT /id="PRO_0000234501"
FT REGION 136..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 119..143
FT /evidence="ECO:0000255"
FT COILED 175..217
FT /evidence="ECO:0000255"
FT COMPBIAS 151..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 137
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CROSSLNK 93
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1)"
FT /evidence="ECO:0000250|UniProtKB:Q96MW1"
FT VAR_SEQ 161..182
FT /note="TLFRNTNVEDVLNARKLERDSL -> SILLFVHPLCFSRSSW (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_018336"
FT VAR_SEQ 183..222
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_018337"
SQ SEQUENCE 222 AA; 25049 MW; 2B6F0029657FCE43 CRC64;
MAAPSEVAAA VLGEGDGGAF GSWLDGRLEA LGVDRAVYAA YILGVLQEEE EEEKLDALQG
ILSAFLEEES LLDICKEIVE RWSETRDVTT KVKKEDEVQA IATLIEKQAQ IVVKPRVVSE
EEKQRKAALL AQYADVTDEE DEADKKDDAG ASTANVSSDR TLFRNTNVED VLNARKLERD
SLRDESQRKK EQDKLQREKD KLAKQERKEK EKKRTQKGER KR
