ID   CCD47_DANRE             Reviewed;         486 AA.
AC   Q66I12;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=PAT complex subunit CCDC47 {ECO:0000250|UniProtKB:Q96A33};
DE   AltName: Full=Coiled-coil domain-containing protein 47;
DE   Flags: Precursor;
GN   Name=ccdc47; ORFNames=zgc:92099;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for the biogenesis, correct folding and transport
CC       of multi-pass membrane proteins into the endoplasmic reticulum (ER)
CC       membrane. Involved in the regulation of calcium ion homeostasis in the
CC       ER. Required for proper protein degradation via the ERAD (ER-associated
CC       degradation) pathway. {ECO:0000250|UniProtKB:Q96A33}.
CC   -!- SUBUNIT: Heteromeric complex composed of WDR83OS/Asterix and CCDC47.
CC       Component of the ribosome-associated ER translocon complex.
CC       {ECO:0000250|UniProtKB:Q96A33}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q96A33}; Single-pass membrane protein
CC       {ECO:0000305}. Rough endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9D024}.
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DR   EMBL; BC081592; AAH81592.1; -; mRNA.
DR   RefSeq; NP_001004551.1; NM_001004551.1.
DR   AlphaFoldDB; Q66I12; -.
DR   SMR; Q66I12; -.
DR   STRING; 7955.ENSDARP00000051541; -.
DR   PaxDb; Q66I12; -.
DR   PRIDE; Q66I12; -.
DR   GeneID; 447812; -.
DR   KEGG; dre:447812; -.
DR   CTD; 57003; -.
DR   ZFIN; ZDB-GENE-040912-15; ccdc47.
DR   eggNOG; KOG2357; Eukaryota.
DR   InParanoid; Q66I12; -.
DR   OrthoDB; 1337297at2759; -.
DR   PhylomeDB; Q66I12; -.
DR   PRO; PR:Q66I12; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0044183; F:protein folding chaperone; ISS:UniProtKB.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:InterPro.
DR   GO; GO:0045048; P:protein insertion into ER membrane; ISS:UniProtKB.
DR   InterPro; IPR012879; CCDC47.
DR   PANTHER; PTHR12883; PTHR12883; 1.
DR   Pfam; PF07946; DUF1682; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endoplasmic reticulum; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..486
FT                   /note="PAT complex subunit CCDC47"
FT                   /id="PRO_0000235802"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          47..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          422..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          421..486
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        72..95
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..474
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   486 AA;  56173 MW;  E8D06EAB110A984F CRC64;
     MRHLVFLLLP ALLLLLALPD TRGRYNDDFD DGEDIAEFDD NDFAEFEDVS EDPAVDVEKE
     PPPRPAPSST PVEDDEDEAT VENEDGQDEF EDTDAQDQDM YNKYDTDEFE GYEKSNPSFK
     DTLIYREVPA HLQNSWESYY MEILMVTGLL AYIMNYIIGK NKNSRLAQAW FNSHRELLES
     NFALVGDDGT SKEATSTGKL NQENEHIYNL WCSGRVCCEG MLIQLKFLKR QDLLNVLARM
     MRPTCDQVQV RVTLNDEDMD TFVFAVGSRK AMARMQKEMQ DLSEFCGDKP KSGAKYGIPD
     SLTILSEMGE VTDGVMDNKM VHYLTSHADK IESIHFSDQF SGPKVMQEEG QPLKLPETKK
     TLLFTFNVPG MGNTSPKDMD SLLPLMNMVI YSIDKVKKLR LNREGKQKAD RNRARVEENF
     LKQTHAQRQE AAQTRREEKK RAEKERIMNE EDPERQRRLE EAAQRREQKK MEKKQMKMKQ
     IKVKAM