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CCD50_RAT
ID   CCD50_RAT               Reviewed;         305 AA.
AC   Q810U0;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Coiled-coil domain-containing protein 50;
DE   AltName: Full=Protein Ymer;
GN   Name=Ccdc50; Synonyms=C3orf6h;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Liver;
RX   PubMed=14527723; DOI=10.1016/s0378-1119(03)00710-8;
RA   Vazza G., Picelli S., Bozzato A., Mostacciuolo M.L.;
RT   "Identification and characterization of C3orf6, a new conserved human gene
RT   mapping to chromosome 3q28.";
RL   Gene 314:113-120(2003).
CC   -!- FUNCTION: Involved in EGFR signaling. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RNF126. {ECO:0000250|UniProtKB:Q810U5}.
CC   -!- PTM: Phosphorylated on tyrosine residues. {ECO:0000250}.
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DR   EMBL; AJ534984; CAD59241.1; -; mRNA.
DR   RefSeq; NP_877400.1; NM_182736.1.
DR   AlphaFoldDB; Q810U0; -.
DR   SMR; Q810U0; -.
DR   BioGRID; 252420; 1.
DR   IntAct; Q810U0; 1.
DR   STRING; 10116.ENSRNOP00000002649; -.
DR   jPOST; Q810U0; -.
DR   PaxDb; Q810U0; -.
DR   PRIDE; Q810U0; -.
DR   GeneID; 288022; -.
DR   KEGG; rno:288022; -.
DR   UCSC; RGD:727841; rat.
DR   CTD; 152137; -.
DR   RGD; 727841; Ccdc50.
DR   VEuPathDB; HostDB:ENSRNOG00000001930; -.
DR   eggNOG; ENOG502S0GI; Eukaryota.
DR   HOGENOM; CLU_032371_0_0_1; -.
DR   InParanoid; Q810U0; -.
DR   OMA; TRNWEKH; -.
DR   OrthoDB; 1110962at2759; -.
DR   PhylomeDB; Q810U0; -.
DR   TreeFam; TF325391; -.
DR   PRO; PR:Q810U0; -.
DR   Proteomes; UP000002494; Chromosome 11.
DR   Bgee; ENSRNOG00000001930; Expressed in spleen and 18 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0015630; C:microtubule cytoskeleton; ISO:RGD.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:RGD.
DR   GO; GO:0007605; P:sensory perception of sound; ISO:RGD.
DR   InterPro; IPR039303; CCDC50.
DR   InterPro; IPR029311; CCDC50_N.
DR   PANTHER; PTHR22115; PTHR22115; 2.
DR   Pfam; PF15295; CCDC50_N; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IVM0"
FT   CHAIN           2..305
FT                   /note="Coiled-coil domain-containing protein 50"
FT                   /id="PRO_0000066309"
FT   REGION          122..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          86..130
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        218..260
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..305
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IVM0"
FT   MOD_RES         5
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IVM0"
SQ   SEQUENCE   305 AA;  35158 MW;  5C100E0B5D536D0C CRC64;
     MADVSVDQSK LPGVKEVCRD FAVLEDHTLA HSLQEQEIEH HLASNIQRNR LVQHDLQVAK
     QLQEEDLKAQ AQLQKRYKAL EQHDCEIAQE IQEKLTIEAE RRRIQEKKDE DIARLLQEKE
     LQEEKKRKKH TPEFSGGSAS GDNYYYEDGG MKSRGINEAV SAPARVSHRD QEWYDAEIAR
     KLQEEELLAT HMDIRAAQVA QDEEIARLLM AEEKKAYKKA KDREKSSLDK RKHDYDCKSK
     AKSAHSKSKE GDETQRAKID RPSRPPPPAA MAPEDVDPTH FTNQHSNTRH FSKSESSHKG
     FHNKQ
 
 
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