CCD50_RAT
ID CCD50_RAT Reviewed; 305 AA.
AC Q810U0;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Coiled-coil domain-containing protein 50;
DE AltName: Full=Protein Ymer;
GN Name=Ccdc50; Synonyms=C3orf6h;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Liver;
RX PubMed=14527723; DOI=10.1016/s0378-1119(03)00710-8;
RA Vazza G., Picelli S., Bozzato A., Mostacciuolo M.L.;
RT "Identification and characterization of C3orf6, a new conserved human gene
RT mapping to chromosome 3q28.";
RL Gene 314:113-120(2003).
CC -!- FUNCTION: Involved in EGFR signaling. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RNF126. {ECO:0000250|UniProtKB:Q810U5}.
CC -!- PTM: Phosphorylated on tyrosine residues. {ECO:0000250}.
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DR EMBL; AJ534984; CAD59241.1; -; mRNA.
DR RefSeq; NP_877400.1; NM_182736.1.
DR AlphaFoldDB; Q810U0; -.
DR SMR; Q810U0; -.
DR BioGRID; 252420; 1.
DR IntAct; Q810U0; 1.
DR STRING; 10116.ENSRNOP00000002649; -.
DR jPOST; Q810U0; -.
DR PaxDb; Q810U0; -.
DR PRIDE; Q810U0; -.
DR GeneID; 288022; -.
DR KEGG; rno:288022; -.
DR UCSC; RGD:727841; rat.
DR CTD; 152137; -.
DR RGD; 727841; Ccdc50.
DR VEuPathDB; HostDB:ENSRNOG00000001930; -.
DR eggNOG; ENOG502S0GI; Eukaryota.
DR HOGENOM; CLU_032371_0_0_1; -.
DR InParanoid; Q810U0; -.
DR OMA; TRNWEKH; -.
DR OrthoDB; 1110962at2759; -.
DR PhylomeDB; Q810U0; -.
DR TreeFam; TF325391; -.
DR PRO; PR:Q810U0; -.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000001930; Expressed in spleen and 18 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0015630; C:microtubule cytoskeleton; ISO:RGD.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:RGD.
DR GO; GO:0007605; P:sensory perception of sound; ISO:RGD.
DR InterPro; IPR039303; CCDC50.
DR InterPro; IPR029311; CCDC50_N.
DR PANTHER; PTHR22115; PTHR22115; 2.
DR Pfam; PF15295; CCDC50_N; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Coiled coil; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8IVM0"
FT CHAIN 2..305
FT /note="Coiled-coil domain-containing protein 50"
FT /id="PRO_0000066309"
FT REGION 122..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..130
FT /evidence="ECO:0000255"
FT COMPBIAS 218..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q8IVM0"
FT MOD_RES 5
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IVM0"
SQ SEQUENCE 305 AA; 35158 MW; 5C100E0B5D536D0C CRC64;
MADVSVDQSK LPGVKEVCRD FAVLEDHTLA HSLQEQEIEH HLASNIQRNR LVQHDLQVAK
QLQEEDLKAQ AQLQKRYKAL EQHDCEIAQE IQEKLTIEAE RRRIQEKKDE DIARLLQEKE
LQEEKKRKKH TPEFSGGSAS GDNYYYEDGG MKSRGINEAV SAPARVSHRD QEWYDAEIAR
KLQEEELLAT HMDIRAAQVA QDEEIARLLM AEEKKAYKKA KDREKSSLDK RKHDYDCKSK
AKSAHSKSKE GDETQRAKID RPSRPPPPAA MAPEDVDPTH FTNQHSNTRH FSKSESSHKG
FHNKQ