CCD54_HUMAN
ID CCD54_HUMAN Reviewed; 328 AA.
AC Q8NEL0; Q96A43;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Coiled-coil domain-containing protein 54;
DE AltName: Full=Testis development protein NYD-SP17;
GN Name=CCDC54;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RA Sha J.H., Zhou Z.M., Li J.M.;
RT "A new testis development gene NYD-SP17 from human testes.";
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-38.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-182, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
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DR EMBL; AF367469; AAK53405.1; -; mRNA.
DR EMBL; AK058091; BAB71661.1; -; mRNA.
DR EMBL; BC030780; AAH30780.1; -; mRNA.
DR CCDS; CCDS2949.1; -.
DR RefSeq; NP_115989.1; NM_032600.2.
DR AlphaFoldDB; Q8NEL0; -.
DR SMR; Q8NEL0; -.
DR BioGRID; 124207; 2.
DR IntAct; Q8NEL0; 1.
DR STRING; 9606.ENSP00000261058; -.
DR iPTMnet; Q8NEL0; -.
DR PhosphoSitePlus; Q8NEL0; -.
DR BioMuta; CCDC54; -.
DR DMDM; 147637038; -.
DR MassIVE; Q8NEL0; -.
DR PaxDb; Q8NEL0; -.
DR PeptideAtlas; Q8NEL0; -.
DR PRIDE; Q8NEL0; -.
DR ProteomicsDB; 73174; -.
DR Antibodypedia; 46519; 150 antibodies from 17 providers.
DR DNASU; 84692; -.
DR Ensembl; ENST00000261058.3; ENSP00000261058.1; ENSG00000138483.3.
DR GeneID; 84692; -.
DR KEGG; hsa:84692; -.
DR MANE-Select; ENST00000261058.3; ENSP00000261058.1; NM_032600.3; NP_115989.1.
DR UCSC; uc003dwi.2; human.
DR CTD; 84692; -.
DR DisGeNET; 84692; -.
DR GeneCards; CCDC54; -.
DR HGNC; HGNC:30703; CCDC54.
DR HPA; ENSG00000138483; Tissue enriched (testis).
DR neXtProt; NX_Q8NEL0; -.
DR OpenTargets; ENSG00000138483; -.
DR PharmGKB; PA142672170; -.
DR VEuPathDB; HostDB:ENSG00000138483; -.
DR eggNOG; ENOG502SSGK; Eukaryota.
DR GeneTree; ENSGT00390000008948; -.
DR HOGENOM; CLU_074373_0_0_1; -.
DR InParanoid; Q8NEL0; -.
DR OMA; LENQNSC; -.
DR OrthoDB; 1013973at2759; -.
DR PhylomeDB; Q8NEL0; -.
DR TreeFam; TF338361; -.
DR PathwayCommons; Q8NEL0; -.
DR SignaLink; Q8NEL0; -.
DR BioGRID-ORCS; 84692; 18 hits in 1065 CRISPR screens.
DR GenomeRNAi; 84692; -.
DR Pharos; Q8NEL0; Tbio.
DR PRO; PR:Q8NEL0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8NEL0; protein.
DR Bgee; ENSG00000138483; Expressed in sperm and 83 other tissues.
DR ExpressionAtlas; Q8NEL0; baseline and differential.
DR Genevisible; Q8NEL0; HS.
DR InterPro; IPR037758; Ccdc54.
DR PANTHER; PTHR37880; PTHR37880; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..328
FT /note="Coiled-coil domain-containing protein 54"
FT /id="PRO_0000286668"
FT COILED 93..151
FT /evidence="ECO:0000255"
FT MOD_RES 182
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT VARIANT 38
FT /note="R -> Q (in dbSNP:rs709564)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_032151"
SQ SEQUENCE 328 AA; 37886 MW; 238D593D97AF3D11 CRC64;
MYTLHTKRVK AAARQMWTSN LSKVRQSLKN VYHKCKIRHQ DSTGYPTVTS DDCNQDDDSY
DGKMNLPVVL QDVKTAQVEL FSQMTDIVHM IPKVQEKTDL YQKQMEVLET RMNVNEDKQC
TTTKDILSMK EDIKALKKKV TELEIQNSCS TIHCLEILEG ERGKEITELL YKLIQPATLK
NTLASTDMEI SSAEPEKVPS YPKSTDHLEK KTISPQMKTL KKRNHQNASR SFEKAKPNIY
IYPDFSTWIK LTFVHGGKWT FFLSATKLEE FIQWLLSRPT ILPEEPQVIT QRYCPFTGPI
LSLTTICLSI FNNIYGFICS LKEEVTRL
