CCD57_HUMAN
ID CCD57_HUMAN Reviewed; 915 AA.
AC Q2TAC2; A6NP51; A8MQC7; Q8IWG2; Q8TER3;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Coiled-coil domain-containing protein 57 {ECO:0000305};
GN Name=CCDC57 {ECO:0000312|HGNC:HGNC:27564};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP MET-480.
RC TISSUE=Brain, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 458-915 (ISOFORM 2).
RC TISSUE=Spleen;
RX PubMed=12693554; DOI=10.1093/dnares/10.1.49;
RA Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N.,
RA Ohara O.;
RT "Characterization of long cDNA clones from human adult spleen. II. The
RT complete sequences of 81 cDNA clones.";
RL DNA Res. 10:49-57(2003).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH CEP63.
RX PubMed=32402286; DOI=10.1016/j.celrep.2020.107630;
RA Gurkaslar H.K., Culfa E., Arslanhan M.D., Lince-Faria M.,
RA Firat-Karalar E.N.;
RT "CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and
RT Regulates Centriole Duplication and Mitotic Progression.";
RL Cell Rep. 31:107630-107630(2020).
CC -!- FUNCTION: Pleiotropic regulator of centriole duplication, mitosis, and
CC ciliogenesis. Critical interface between centrosome and microtubule-
CC mediated cellular processes. Centriole duplication protein required for
CC recruitment of CEP63, CEP152, and PLK4 to the centrosome. Independent
CC of its centrosomal targeting, localizes to and interacts with
CC microtubules and regulates microtubule nucleation, stability, and
CC mitotic progression. {ECO:0000269|PubMed:32402286}.
CC -!- SUBUNIT: Interacts with CEP63; the interaction is required for their
CC location to proximal end of centrioles (PubMed:32402286). Interacts
CC with microtubules (PubMed:32402286). {ECO:0000269|PubMed:32402286}.
CC -!- INTERACTION:
CC Q2TAC2; P29972: AQP1; NbExp=3; IntAct=EBI-2808286, EBI-745213;
CC Q2TAC2; P40617: ARL4A; NbExp=3; IntAct=EBI-2808286, EBI-2875746;
CC Q2TAC2; Q9HC52: CBX8; NbExp=3; IntAct=EBI-2808286, EBI-712912;
CC Q2TAC2; Q96HB5-4: CCDC120; NbExp=3; IntAct=EBI-2808286, EBI-10185348;
CC Q2TAC2; Q86Y33: CDC20B; NbExp=3; IntAct=EBI-2808286, EBI-10260504;
CC Q2TAC2; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-2808286, EBI-10181988;
CC Q2TAC2; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-2808286, EBI-5453285;
CC Q2TAC2; Q3B820: FAM161A; NbExp=3; IntAct=EBI-2808286, EBI-719941;
CC Q2TAC2; Q9Y247: FAM50B; NbExp=3; IntAct=EBI-2808286, EBI-742802;
CC Q2TAC2; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-2808286, EBI-6658203;
CC Q2TAC2; Q92917: GPKOW; NbExp=3; IntAct=EBI-2808286, EBI-746309;
CC Q2TAC2; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-2808286, EBI-2514791;
CC Q2TAC2; P69905: HBA2; NbExp=3; IntAct=EBI-2808286, EBI-714680;
CC Q2TAC2; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-2808286, EBI-726510;
CC Q2TAC2; Q96FQ7: LINC00526; NbExp=3; IntAct=EBI-2808286, EBI-10286106;
CC Q2TAC2; P55081: MFAP1; NbExp=3; IntAct=EBI-2808286, EBI-1048159;
CC Q2TAC2; Q6XQN6-2: NAPRT; NbExp=3; IntAct=EBI-2808286, EBI-10254820;
CC Q2TAC2; P18615: NELFE; NbExp=3; IntAct=EBI-2808286, EBI-348444;
CC Q2TAC2; Q14980: NUMA1; NbExp=3; IntAct=EBI-2808286, EBI-521611;
CC Q2TAC2; Q8NEY8: PPHLN1; NbExp=3; IntAct=EBI-2808286, EBI-474076;
CC Q2TAC2; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-2808286, EBI-2557469;
CC Q2TAC2; Q96QH2: PRAM1; NbExp=3; IntAct=EBI-2808286, EBI-2860740;
CC Q2TAC2; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-2808286, EBI-1567797;
CC Q2TAC2; P79522: PRR3; NbExp=3; IntAct=EBI-2808286, EBI-2803328;
CC Q2TAC2; P35236: PTPN7; NbExp=3; IntAct=EBI-2808286, EBI-2265723;
CC Q2TAC2; Q8TBN0: RAB3IL1; NbExp=3; IntAct=EBI-2808286, EBI-743796;
CC Q2TAC2; Q96HH0: ROBO3; NbExp=3; IntAct=EBI-2808286, EBI-10288358;
CC Q2TAC2; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-2808286, EBI-8787464;
CC Q2TAC2; Q08117: TLE5; NbExp=3; IntAct=EBI-2808286, EBI-717810;
CC Q2TAC2; Q9NV29: TMEM100; NbExp=3; IntAct=EBI-2808286, EBI-8644968;
CC Q2TAC2; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-2808286, EBI-10241197;
CC Q2TAC2; Q9Y4E8: USP15; NbExp=3; IntAct=EBI-2808286, EBI-1043104;
CC Q2TAC2; O75604: USP2; NbExp=3; IntAct=EBI-2808286, EBI-743272;
CC Q2TAC2; Q08E77: UTP14C; NbExp=3; IntAct=EBI-2808286, EBI-10225961;
CC Q2TAC2; G3V1X1: ZFC3H1; NbExp=3; IntAct=EBI-2808286, EBI-6448783;
CC Q2TAC2; Q8N5A5: ZGPAT; NbExp=3; IntAct=EBI-2808286, EBI-3439227;
CC Q2TAC2; Q96NC0: ZMAT2; NbExp=3; IntAct=EBI-2808286, EBI-2682299;
CC Q2TAC2; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-2808286, EBI-740727;
CC Q2TAC2; PRO_0000449631 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-2808286, EBI-25475920;
CC Q2TAC2-2; Q8IZP0-5: ABI1; NbExp=3; IntAct=EBI-10961624, EBI-11743294;
CC Q2TAC2-2; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-10961624, EBI-11096309;
CC Q2TAC2-2; O14639-4: ABLIM1; NbExp=3; IntAct=EBI-10961624, EBI-11030084;
CC Q2TAC2-2; Q9Y2J4: AMOTL2; NbExp=3; IntAct=EBI-10961624, EBI-746752;
CC Q2TAC2-2; Q86SG2: ANKRD23; NbExp=3; IntAct=EBI-10961624, EBI-5661893;
CC Q2TAC2-2; Q03989: ARID5A; NbExp=3; IntAct=EBI-10961624, EBI-948603;
CC Q2TAC2-2; A0A0S2Z4M1: AXIN1; NbExp=3; IntAct=EBI-10961624, EBI-16429430;
CC Q2TAC2-2; O15169: AXIN1; NbExp=3; IntAct=EBI-10961624, EBI-710484;
CC Q2TAC2-2; O75815: BCAR3; NbExp=3; IntAct=EBI-10961624, EBI-702336;
CC Q2TAC2-2; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-10961624, EBI-745073;
CC Q2TAC2-2; Q9H6X5-2: C19orf44; NbExp=3; IntAct=EBI-10961624, EBI-12061599;
CC Q2TAC2-2; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-10961624, EBI-739879;
CC Q2TAC2-2; Q96LM5: C4orf45; NbExp=3; IntAct=EBI-10961624, EBI-12020542;
CC Q2TAC2-2; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-10961624, EBI-11524851;
CC Q2TAC2-2; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-10961624, EBI-744556;
CC Q2TAC2-2; Q96M91: CFAP53; NbExp=3; IntAct=EBI-10961624, EBI-742422;
CC Q2TAC2-2; P38432: COIL; NbExp=3; IntAct=EBI-10961624, EBI-945751;
CC Q2TAC2-2; Q53ET0: CRTC2; NbExp=3; IntAct=EBI-10961624, EBI-1181987;
CC Q2TAC2-2; G5E9L9: DCLK2; NbExp=3; IntAct=EBI-10961624, EBI-12174057;
CC Q2TAC2-2; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-10961624, EBI-11988027;
CC Q2TAC2-2; Q86UW9: DTX2; NbExp=3; IntAct=EBI-10961624, EBI-740376;
CC Q2TAC2-2; Q5JST6: EFHC2; NbExp=3; IntAct=EBI-10961624, EBI-2349927;
CC Q2TAC2-2; O15371: EIF3D; NbExp=3; IntAct=EBI-10961624, EBI-353818;
CC Q2TAC2-2; Q04637-9: EIF4G1; NbExp=3; IntAct=EBI-10961624, EBI-12012124;
CC Q2TAC2-2; Q14241: ELOA; NbExp=3; IntAct=EBI-10961624, EBI-742350;
CC Q2TAC2-2; Q9NT22: EMILIN3; NbExp=3; IntAct=EBI-10961624, EBI-3197883;
CC Q2TAC2-2; Q96DF8: ESS2; NbExp=3; IntAct=EBI-10961624, EBI-3928124;
CC Q2TAC2-2; O95990-4: FAM107A; NbExp=3; IntAct=EBI-10961624, EBI-11977223;
CC Q2TAC2-2; Q3B820: FAM161A; NbExp=6; IntAct=EBI-10961624, EBI-719941;
CC Q2TAC2-2; Q96MY7: FAM161B; NbExp=6; IntAct=EBI-10961624, EBI-7225287;
CC Q2TAC2-2; Q86W67: FAM228A; NbExp=3; IntAct=EBI-10961624, EBI-12958227;
CC Q2TAC2-2; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-10961624, EBI-6658203;
CC Q2TAC2-2; P07954: FH; NbExp=3; IntAct=EBI-10961624, EBI-1050358;
CC Q2TAC2-2; Q9NU39: FOXD4L1; NbExp=3; IntAct=EBI-10961624, EBI-11320806;
CC Q2TAC2-2; Q9C0B1-2: FTO; NbExp=3; IntAct=EBI-10961624, EBI-18138793;
CC Q2TAC2-2; P14136: GFAP; NbExp=3; IntAct=EBI-10961624, EBI-744302;
CC Q2TAC2-2; O75420: GIGYF1; NbExp=3; IntAct=EBI-10961624, EBI-947774;
CC Q2TAC2-2; Q86WP2: GPBP1; NbExp=3; IntAct=EBI-10961624, EBI-2349758;
CC Q2TAC2-2; Q9HAV7: GRPEL1; NbExp=3; IntAct=EBI-10961624, EBI-1043499;
CC Q2TAC2-2; Q7Z353: HDX; NbExp=3; IntAct=EBI-10961624, EBI-1052734;
CC Q2TAC2-2; Q8IYA8: IHO1; NbExp=3; IntAct=EBI-10961624, EBI-8638439;
CC Q2TAC2-2; Q9UKT9: IKZF3; NbExp=5; IntAct=EBI-10961624, EBI-747204;
CC Q2TAC2-2; Q0VD86: INCA1; NbExp=3; IntAct=EBI-10961624, EBI-6509505;
CC Q2TAC2-2; Q9H0H0: INTS2; NbExp=3; IntAct=EBI-10961624, EBI-8471507;
CC Q2TAC2-2; O75564-2: JRK; NbExp=3; IntAct=EBI-10961624, EBI-17181882;
CC Q2TAC2-2; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-10961624, EBI-2556193;
CC Q2TAC2-2; Q6ZU52: KIAA0408; NbExp=3; IntAct=EBI-10961624, EBI-739493;
CC Q2TAC2-2; Q13351: KLF1; NbExp=3; IntAct=EBI-10961624, EBI-8284732;
CC Q2TAC2-2; Q9UIH9: KLF15; NbExp=3; IntAct=EBI-10961624, EBI-2796400;
CC Q2TAC2-2; Q5T749: KPRP; NbExp=3; IntAct=EBI-10961624, EBI-10981970;
CC Q2TAC2-2; P19013: KRT4; NbExp=3; IntAct=EBI-10961624, EBI-2371606;
CC Q2TAC2-2; Q01546: KRT76; NbExp=3; IntAct=EBI-10961624, EBI-2952745;
CC Q2TAC2-2; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-10961624, EBI-11953846;
CC Q2TAC2-2; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-10961624, EBI-10241252;
CC Q2TAC2-2; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-10961624, EBI-726510;
CC Q2TAC2-2; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-10961624, EBI-1216080;
CC Q2TAC2-2; Q9Y6D9: MAD1L1; NbExp=3; IntAct=EBI-10961624, EBI-742610;
CC Q2TAC2-2; Q8TC05: MDM1; NbExp=3; IntAct=EBI-10961624, EBI-3951677;
CC Q2TAC2-2; P04732: MT1E; NbExp=3; IntAct=EBI-10961624, EBI-12310079;
CC Q2TAC2-2; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-10961624, EBI-5662487;
CC Q2TAC2-2; Q15742: NAB2; NbExp=3; IntAct=EBI-10961624, EBI-8641936;
CC Q2TAC2-2; O00746: NME4; NbExp=5; IntAct=EBI-10961624, EBI-744871;
CC Q2TAC2-2; Q9P286: PAK5; NbExp=3; IntAct=EBI-10961624, EBI-741896;
CC Q2TAC2-2; Q96HA1-2: POM121; NbExp=3; IntAct=EBI-10961624, EBI-11956563;
CC Q2TAC2-2; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-10961624, EBI-12000762;
CC Q2TAC2-2; Q96QH2: PRAM1; NbExp=3; IntAct=EBI-10961624, EBI-2860740;
CC Q2TAC2-2; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-10961624, EBI-11320284;
CC Q2TAC2-2; Q2NL68: PROSER3; NbExp=3; IntAct=EBI-10961624, EBI-11336487;
CC Q2TAC2-2; Q99633: PRPF18; NbExp=3; IntAct=EBI-10961624, EBI-2798416;
CC Q2TAC2-2; Q8WWY3: PRPF31; NbExp=6; IntAct=EBI-10961624, EBI-1567797;
CC Q2TAC2-2; P28070: PSMB4; NbExp=3; IntAct=EBI-10961624, EBI-603350;
CC Q2TAC2-2; Q3KNS1: PTCHD3; NbExp=3; IntAct=EBI-10961624, EBI-2860313;
CC Q2TAC2-2; Q9Y272: RASD1; NbExp=3; IntAct=EBI-10961624, EBI-740818;
CC Q2TAC2-2; Q5RL73: RBM48; NbExp=3; IntAct=EBI-10961624, EBI-473821;
CC Q2TAC2-2; Q8NG50: RDM1; NbExp=5; IntAct=EBI-10961624, EBI-10288724;
CC Q2TAC2-2; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-10961624, EBI-726876;
CC Q2TAC2-2; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-10961624, EBI-16428950;
CC Q2TAC2-2; Q96HH0: ROBO3; NbExp=3; IntAct=EBI-10961624, EBI-10288358;
CC Q2TAC2-2; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-10961624, EBI-6257312;
CC Q2TAC2-2; Q96B97: SH3KBP1; NbExp=3; IntAct=EBI-10961624, EBI-346595;
CC Q2TAC2-2; Q6ZSJ9: SHISA6; NbExp=3; IntAct=EBI-10961624, EBI-12037847;
CC Q2TAC2-2; Q6ZT89-3: SLC25A48; NbExp=3; IntAct=EBI-10961624, EBI-12065614;
CC Q2TAC2-2; Q9H0W8: SMG9; NbExp=3; IntAct=EBI-10961624, EBI-2872322;
CC Q2TAC2-2; Q8NCR6: SMRP1; NbExp=3; IntAct=EBI-10961624, EBI-10269322;
CC Q2TAC2-2; Q16560-2: SNRNP35; NbExp=3; IntAct=EBI-10961624, EBI-12938570;
CC Q2TAC2-2; O60504: SORBS3; NbExp=3; IntAct=EBI-10961624, EBI-741237;
CC Q2TAC2-2; O43609: SPRY1; NbExp=3; IntAct=EBI-10961624, EBI-3866665;
CC Q2TAC2-2; Q5T7P8-2: SYT6; NbExp=3; IntAct=EBI-10961624, EBI-10246152;
CC Q2TAC2-2; Q8TDR4: TCP10L; NbExp=3; IntAct=EBI-10961624, EBI-3923210;
CC Q2TAC2-2; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-10961624, EBI-1105213;
CC Q2TAC2-2; P0C1Z6: TFPT; NbExp=3; IntAct=EBI-10961624, EBI-1245626;
CC Q2TAC2-2; O43615: TIMM44; NbExp=3; IntAct=EBI-10961624, EBI-861737;
CC Q2TAC2-2; Q9NV29: TMEM100; NbExp=3; IntAct=EBI-10961624, EBI-8644968;
CC Q2TAC2-2; P19237: TNNI1; NbExp=3; IntAct=EBI-10961624, EBI-746692;
CC Q2TAC2-2; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-10961624, EBI-11952721;
CC Q2TAC2-2; Q14142: TRIM14; NbExp=3; IntAct=EBI-10961624, EBI-2820256;
CC Q2TAC2-2; Q14134: TRIM29; NbExp=6; IntAct=EBI-10961624, EBI-702370;
CC Q2TAC2-2; Q7Z6J9: TSEN54; NbExp=3; IntAct=EBI-10961624, EBI-2559824;
CC Q2TAC2-2; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-10961624, EBI-10241197;
CC Q2TAC2-2; Q9NRE2: TSHZ2; NbExp=3; IntAct=EBI-10961624, EBI-10687282;
CC Q2TAC2-2; P40222: TXLNA; NbExp=3; IntAct=EBI-10961624, EBI-359793;
CC Q2TAC2-2; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-10961624, EBI-2799833;
CC Q2TAC2-2; Q9BW85: YJU2; NbExp=3; IntAct=EBI-10961624, EBI-10300345;
CC Q2TAC2-2; Q9P1Z0: ZBTB4; NbExp=3; IntAct=EBI-10961624, EBI-2564133;
CC Q2TAC2-2; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-10961624, EBI-14104088;
CC Q2TAC2-2; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-10961624, EBI-10183064;
CC Q2TAC2-2; Q9C0F3: ZNF436; NbExp=3; IntAct=EBI-10961624, EBI-8489702;
CC Q2TAC2-2; Q6S9Z5: ZNF474; NbExp=3; IntAct=EBI-10961624, EBI-17269964;
CC Q2TAC2-2; Q9H707: ZNF552; NbExp=3; IntAct=EBI-10961624, EBI-2555731;
CC Q2TAC2-2; Q5T619: ZNF648; NbExp=3; IntAct=EBI-10961624, EBI-11985915;
CC Q2TAC2-2; Q8N720: ZNF655; NbExp=3; IntAct=EBI-10961624, EBI-625509;
CC Q2TAC2-2; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-10961624, EBI-16429014;
CC Q2TAC2-2; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-10961624, EBI-5667516;
CC Q2TAC2-2; Q96MP5: ZSWIM3; NbExp=3; IntAct=EBI-10961624, EBI-5235554;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:32402286}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome, centriolar
CC satellite {ECO:0000269|PubMed:32402286}. Cytoplasm, cytoskeleton,
CC microtubule organizing center, centrosome, centriole
CC {ECO:0000269|PubMed:32402286}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000269|PubMed:32402286}. Note=Localizes to resolvable rings at
CC the proximal end of centrioles (PubMed:32402286). In mitotic cells,
CC localizes to spindle microtubules during metaphase (PubMed:32402286).
CC {ECO:0000269|PubMed:32402286}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2TAC2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2TAC2-2; Sequence=VSP_025802, VSP_025803;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI10998.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
CC Sequence=EAW89746.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC129510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC132872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC135056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471099; EAW89746.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC040264; AAH40264.1; -; mRNA.
DR EMBL; BC110997; AAI10998.1; ALT_SEQ; mRNA.
DR EMBL; AK074059; BAB84885.1; -; mRNA.
DR CCDS; CCDS11803.1; -. [Q2TAC2-2]
DR RefSeq; NP_001303250.1; NM_001316321.1. [Q2TAC2-2]
DR RefSeq; NP_932348.2; NM_198082.2. [Q2TAC2-1]
DR AlphaFoldDB; Q2TAC2; -.
DR SMR; Q2TAC2; -.
DR BioGRID; 129725; 166.
DR IntAct; Q2TAC2; 154.
DR STRING; 9606.ENSP00000374292; -.
DR GlyGen; Q2TAC2; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q2TAC2; -.
DR PhosphoSitePlus; Q2TAC2; -.
DR BioMuta; CCDC57; -.
DR DMDM; 317373337; -.
DR jPOST; Q2TAC2; -.
DR MassIVE; Q2TAC2; -.
DR MaxQB; Q2TAC2; -.
DR PaxDb; Q2TAC2; -.
DR PeptideAtlas; Q2TAC2; -.
DR PRIDE; Q2TAC2; -.
DR ProteomicsDB; 61457; -. [Q2TAC2-1]
DR ProteomicsDB; 61458; -. [Q2TAC2-2]
DR TopDownProteomics; Q2TAC2-1; -. [Q2TAC2-1]
DR Antibodypedia; 19887; 60 antibodies from 11 providers.
DR DNASU; 284001; -.
DR Ensembl; ENST00000389641.9; ENSP00000374292.5; ENSG00000176155.20. [Q2TAC2-1]
DR Ensembl; ENST00000392343.3; ENSP00000376154.3; ENSG00000176155.20. [Q2TAC2-2]
DR GeneID; 284001; -.
DR KEGG; hsa:284001; -.
DR UCSC; uc002kdz.2; human. [Q2TAC2-1]
DR CTD; 284001; -.
DR DisGeNET; 284001; -.
DR GeneCards; CCDC57; -.
DR HGNC; HGNC:27564; CCDC57.
DR HPA; ENSG00000176155; Low tissue specificity.
DR neXtProt; NX_Q2TAC2; -.
DR OpenTargets; ENSG00000176155; -.
DR PharmGKB; PA142672173; -.
DR VEuPathDB; HostDB:ENSG00000176155; -.
DR eggNOG; ENOG502QSW3; Eukaryota.
DR GeneTree; ENSGT00940000153251; -.
DR HOGENOM; CLU_011424_1_0_1; -.
DR InParanoid; Q2TAC2; -.
DR OrthoDB; 490834at2759; -.
DR PhylomeDB; Q2TAC2; -.
DR TreeFam; TF333001; -.
DR PathwayCommons; Q2TAC2; -.
DR SignaLink; Q2TAC2; -.
DR BioGRID-ORCS; 284001; 9 hits in 256 CRISPR screens.
DR ChiTaRS; CCDC57; human.
DR GeneWiki; CCDC57; -.
DR GenomeRNAi; 284001; -.
DR Pharos; Q2TAC2; Tdark.
DR PRO; PR:Q2TAC2; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q2TAC2; protein.
DR Bgee; ENSG00000176155; Expressed in right uterine tube and 128 other tissues.
DR ExpressionAtlas; Q2TAC2; baseline and differential.
DR Genevisible; Q2TAC2; HS.
DR GO; GO:0034451; C:centriolar satellite; IDA:UniProtKB.
DR GO; GO:0005814; C:centriole; IDA:UniProtKB.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005876; C:spindle microtubule; IDA:UniProtKB.
DR GO; GO:0007099; P:centriole replication; IDA:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; IDA:UniProtKB.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IDA:UniProtKB.
DR GO; GO:0007020; P:microtubule nucleation; IDA:UniProtKB.
DR GO; GO:0045931; P:positive regulation of mitotic cell cycle; IDA:UniProtKB.
DR InterPro; IPR042481; CCDC57.
DR PANTHER; PTHR46725; PTHR46725; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..915
FT /note="Coiled-coil domain-containing protein 57"
FT /id="PRO_0000288871"
FT REGION 1..502
FT /note="Centrosomal targeting domain"
FT /evidence="ECO:0000269|PubMed:32402286"
FT REGION 555..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..915
FT /note="Microtubule binding domain"
FT /evidence="ECO:0000269|PubMed:32402286"
FT REGION 606..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 92..173
FT /evidence="ECO:0000255"
FT COILED 214..422
FT /evidence="ECO:0000255"
FT COILED 456..483
FT /evidence="ECO:0000255"
FT COILED 521..548
FT /evidence="ECO:0000255"
FT COMPBIAS 612..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..762
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..818
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 748..751
FT /note="DAKS -> VGAR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12693554,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_025802"
FT VAR_SEQ 752..915
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12693554,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_025803"
FT VARIANT 237
FT /note="E -> Q (in dbSNP:rs34543170)"
FT /id="VAR_032516"
FT VARIANT 321
FT /note="Q -> R (in dbSNP:rs7406116)"
FT /id="VAR_032517"
FT VARIANT 480
FT /note="V -> M (in dbSNP:rs7209474)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_032518"
FT VARIANT 774
FT /note="R -> G (in dbSNP:rs4625783)"
FT /id="VAR_032519"
FT VARIANT 776
FT /note="D -> N (in dbSNP:rs7406163)"
FT /id="VAR_032520"
FT VARIANT 777
FT /note="A -> T (in dbSNP:rs7406162)"
FT /id="VAR_032521"
FT VARIANT 810
FT /note="Q -> K (in dbSNP:rs7213172)"
FT /id="VAR_032522"
FT VARIANT 833
FT /note="M -> T (in dbSNP:rs11077969)"
FT /id="VAR_032523"
FT CONFLICT 458
FT /note="Q -> K (in Ref. 4; BAB84885)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 915 AA; 103039 MW; EACE3433538F7FC2 CRC64;
MLPLGSEPAL NELLLRKEEE WRALQAHRTQ LQEAALQDTR SQLEEAQGKL RCLQEDFVYN
LQVLEERDLE LERYDAAFAQ AREWEEARRA EVSELKIEAA KLRQALAREA RKVEELQQQQ
QLAFQEHRLE LERVHSDKNG EIDHHREQYE NLKWTLERKL EELDGELALQ RQELLLEFES
KMRKREHEFR LQADNMSNTA LSRELKVKLL HKELEALKEA GAKAAESLQR AEATNAELER
KLQSRAGELQ DLEAMSRARV KDLEDKLHSV QLTRKKEEET FKRKHEELDR LAREKDAVLV
AVKGAHVEQL QELQTRVLEL QAHCETLEAQ LRRAEWRQAD TAKEKDAAID QLREDASTVK
SAWDAQIAQL SKEMVSRDLQ IQTLQEEEVK LKAQVARSQQ DIERYKQQLS LAVERERSLE
RDQVQLGLDW QRRCDDIERD QIQKSEALIQ GLSMAKSQVA AKLQETEQAL QEQEVVLKAV
TLERDQAVQA LRMHGLPRPG AQMLLRQHEE EISKDFPSSE IQRLREQNTS LRNAIAQMRK
EMEALSHQIP PPIQTAAEST DANQPDPEAG GDAATPDYVL ALEAEIRTLK HKFKTLEKHL
EDVLDPLKMS SPHAESQPSV RTSTETTGGS AQAGQAGGSV QAGQAGGSVQ AGPVSSGLAL
RKLGDRVQLL NLLVTRLRQK VLREPLEPAA LQRELPREVD QVHLEVLELR KQVAELGKHL
RIAQHGGAEP SGRKQPPASD AVALGREDAK SAEDEAPSRH LGKHQPRSAQ VGSRLDALQG
PKTQHSIHTV TCKSPRQKED RSPKPPQAPQ HPEEHGRQSH SSSSFASGTL QDMWRLLDLG
SSPSGVTSQG DSTPELPAPP AADRRPVKMQ AGIATPGMKT AAQAKAKTTG ASRSHPAKAK
GCQRPPKIRN YNIMD
