CCD60_HUMAN
ID CCD60_HUMAN Reviewed; 550 AA.
AC Q8IWA6;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Coiled-coil domain-containing protein 60;
GN Name=CCDC60;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8IWA6; Q5JR59: MTUS2; NbExp=4; IntAct=EBI-10262147, EBI-742948;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC002070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC084881; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC040553; AAH40553.1; -; mRNA.
DR CCDS; CCDS9190.1; -.
DR RefSeq; NP_848594.2; NM_178499.4.
DR AlphaFoldDB; Q8IWA6; -.
DR BioGRID; 127766; 12.
DR IntAct; Q8IWA6; 8.
DR STRING; 9606.ENSP00000333374; -.
DR iPTMnet; Q8IWA6; -.
DR PhosphoSitePlus; Q8IWA6; -.
DR BioMuta; CCDC60; -.
DR DMDM; 296434427; -.
DR MassIVE; Q8IWA6; -.
DR MaxQB; Q8IWA6; -.
DR PaxDb; Q8IWA6; -.
DR PeptideAtlas; Q8IWA6; -.
DR PRIDE; Q8IWA6; -.
DR ProteomicsDB; 70832; -.
DR Antibodypedia; 31402; 94 antibodies from 14 providers.
DR DNASU; 160777; -.
DR Ensembl; ENST00000327554.3; ENSP00000333374.2; ENSG00000183273.7.
DR GeneID; 160777; -.
DR KEGG; hsa:160777; -.
DR MANE-Select; ENST00000327554.3; ENSP00000333374.2; NM_178499.5; NP_848594.2.
DR UCSC; uc001txe.3; human.
DR CTD; 160777; -.
DR DisGeNET; 160777; -.
DR GeneCards; CCDC60; -.
DR HGNC; HGNC:28610; CCDC60.
DR HPA; ENSG00000183273; Tissue enhanced (choroid plexus, fallopian tube, testis).
DR neXtProt; NX_Q8IWA6; -.
DR OpenTargets; ENSG00000183273; -.
DR PharmGKB; PA143485413; -.
DR VEuPathDB; HostDB:ENSG00000183273; -.
DR eggNOG; ENOG502QVFX; Eukaryota.
DR GeneTree; ENSGT00390000015428; -.
DR HOGENOM; CLU_036722_0_0_1; -.
DR InParanoid; Q8IWA6; -.
DR OMA; MQRKAPS; -.
DR OrthoDB; 1215093at2759; -.
DR PhylomeDB; Q8IWA6; -.
DR TreeFam; TF336372; -.
DR PathwayCommons; Q8IWA6; -.
DR SignaLink; Q8IWA6; -.
DR BioGRID-ORCS; 160777; 6 hits in 1062 CRISPR screens.
DR ChiTaRS; CCDC60; human.
DR GenomeRNAi; 160777; -.
DR Pharos; Q8IWA6; Tdark.
DR PRO; PR:Q8IWA6; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8IWA6; protein.
DR Bgee; ENSG00000183273; Expressed in bronchial epithelial cell and 120 other tissues.
DR ExpressionAtlas; Q8IWA6; baseline and differential.
DR Genevisible; Q8IWA6; HS.
DR InterPro; IPR031526; DUF4698.
DR PANTHER; PTHR34754; PTHR34754; 1.
DR Pfam; PF15769; DUF4698; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..550
FT /note="Coiled-coil domain-containing protein 60"
FT /id="PRO_0000239665"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 71..98
FT /evidence="ECO:0000255"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 46
FT /note="I -> V (in dbSNP:rs1064319)"
FT /id="VAR_033667"
FT VARIANT 115
FT /note="T -> A (in dbSNP:rs2519540)"
FT /id="VAR_033668"
FT VARIANT 393
FT /note="V -> I (in dbSNP:rs16949292)"
FT /id="VAR_033669"
FT CONFLICT 219
FT /note="K -> E (in Ref. 2; AAH40553)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 550 AA; 63091 MW; DD48DC84933C3C61 CRC64;
MTKVPATKKL QSSPNSGAVR PFYASENLRQ VPDKPMKSIK YMDKEIINLK KDLIRSRFLI
QSVKIGRGYF AILREETAKK KKQQQLQKLK EEERNKFQPA EKISEIHYGD TLLSTYDDEK
LKTLGARVTR RPFTPIHSCI ISPSLTEAHV EPLFRQLCAL HWLLEALTID HTHHTMKPVI
TCWNPKDPGG SKSTIKKINK DKSMGQKWEH FITAPKTKKF KIPTMRVTNR KPSRRGSTLS
LSRASGGSSP QSSMISVNPG SDEPPSVNTQ VTSSKDIEDN ESSSTKPDEE PLYMNLQKLL
EMVREDARRT VTIENGMQRK APSILSVLKQ NKSNSAYKEM QTTLKSSERS SSTSAESHIQ
PVQKKSKNRT NCDINIHYKS GVCNTMRAKF YSVAQEAGFC LQDKMEILMK RQEERGIQKF
RAFVLVSNFQ KDIAKMRHHI SVVKGDAEEI ADHWYFDLLS KLPEDLKNFR PAKKILVKLQ
KFGENLDLRI RPHVLLKVLQ DLRIWELCSP DIAVAIEFVR EHIIHMPQED YISWLQSRIN
IPIGPYSALR
